Monocyte Trajectories Endotypes Are Associated With Worsening in Septic Patients
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. The immune system plays a key role in sepsis onset and remains dysregulated over time in a heterogeneous manner. Here, we decipher the heterogeneity of the first week evolution of the monocyte HLA-DR...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:2cd9c0d146304e6d83a767d4e12c26e62021-12-01T13:59:14ZMonocyte Trajectories Endotypes Are Associated With Worsening in Septic Patients1664-322410.3389/fimmu.2021.795052https://doaj.org/article/2cd9c0d146304e6d83a767d4e12c26e62021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.795052/fullhttps://doaj.org/toc/1664-3224Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. The immune system plays a key role in sepsis onset and remains dysregulated over time in a heterogeneous manner. Here, we decipher the heterogeneity of the first week evolution of the monocyte HLA-DR (mHLA-DR) surface protein expression in septic patients, a key molecule for adaptive immunity onset. We found and verified four distinctive trajectories endotypes in a discovery (n = 276) and a verification cohort (n = 102). We highlight that 59% of septic patients exhibit low or decreasing mHLA-DR expression while in others mHLA-DR expression increased. This study depicts the first week behavior of mHLA-DR over time after sepsis onset and shows that initial and third day mHLA-DR expression measurements is sufficient for an early risk stratification of sepsis patients. These patients might benefit from immunomodulatory treatment to improve outcomes. Going further, our study introduces a way of deciphering heterogeneity of immune system after sepsis onset which is a first step to reach a more comprehensive landscape of sepsis.Maxime BodinierEstelle PeronnetKaren Brengel-PesceFilippo ContiThomas RimmeléJulien TextorisChristophe VedrineLaurence QuemeneurAndrew D. GriffithsLionel K. TanFabienne VenetFabienne VenetDelphine Maucort-BoulchDelphine Maucort-BoulchDelphine Maucort-BoulchGuillaume Monneretthe REALISM study groupFrontiers Media S.A.articlesepsisendotypetrajectoryimmune monitoringICU– Intensive Care Unitmonocyte HLA-DRImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021) |
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EN |
| topic |
sepsis endotype trajectory immune monitoring ICU– Intensive Care Unit monocyte HLA-DR Immunologic diseases. Allergy RC581-607 |
| spellingShingle |
sepsis endotype trajectory immune monitoring ICU– Intensive Care Unit monocyte HLA-DR Immunologic diseases. Allergy RC581-607 Maxime Bodinier Estelle Peronnet Karen Brengel-Pesce Filippo Conti Thomas Rimmelé Julien Textoris Christophe Vedrine Laurence Quemeneur Andrew D. Griffiths Lionel K. Tan Fabienne Venet Fabienne Venet Delphine Maucort-Boulch Delphine Maucort-Boulch Delphine Maucort-Boulch Guillaume Monneret the REALISM study group Monocyte Trajectories Endotypes Are Associated With Worsening in Septic Patients |
| description |
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. The immune system plays a key role in sepsis onset and remains dysregulated over time in a heterogeneous manner. Here, we decipher the heterogeneity of the first week evolution of the monocyte HLA-DR (mHLA-DR) surface protein expression in septic patients, a key molecule for adaptive immunity onset. We found and verified four distinctive trajectories endotypes in a discovery (n = 276) and a verification cohort (n = 102). We highlight that 59% of septic patients exhibit low or decreasing mHLA-DR expression while in others mHLA-DR expression increased. This study depicts the first week behavior of mHLA-DR over time after sepsis onset and shows that initial and third day mHLA-DR expression measurements is sufficient for an early risk stratification of sepsis patients. These patients might benefit from immunomodulatory treatment to improve outcomes. Going further, our study introduces a way of deciphering heterogeneity of immune system after sepsis onset which is a first step to reach a more comprehensive landscape of sepsis. |
| format |
article |
| author |
Maxime Bodinier Estelle Peronnet Karen Brengel-Pesce Filippo Conti Thomas Rimmelé Julien Textoris Christophe Vedrine Laurence Quemeneur Andrew D. Griffiths Lionel K. Tan Fabienne Venet Fabienne Venet Delphine Maucort-Boulch Delphine Maucort-Boulch Delphine Maucort-Boulch Guillaume Monneret the REALISM study group |
| author_facet |
Maxime Bodinier Estelle Peronnet Karen Brengel-Pesce Filippo Conti Thomas Rimmelé Julien Textoris Christophe Vedrine Laurence Quemeneur Andrew D. Griffiths Lionel K. Tan Fabienne Venet Fabienne Venet Delphine Maucort-Boulch Delphine Maucort-Boulch Delphine Maucort-Boulch Guillaume Monneret the REALISM study group |
| author_sort |
Maxime Bodinier |
| title |
Monocyte Trajectories Endotypes Are Associated With Worsening in Septic Patients |
| title_short |
Monocyte Trajectories Endotypes Are Associated With Worsening in Septic Patients |
| title_full |
Monocyte Trajectories Endotypes Are Associated With Worsening in Septic Patients |
| title_fullStr |
Monocyte Trajectories Endotypes Are Associated With Worsening in Septic Patients |
| title_full_unstemmed |
Monocyte Trajectories Endotypes Are Associated With Worsening in Septic Patients |
| title_sort |
monocyte trajectories endotypes are associated with worsening in septic patients |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/2cd9c0d146304e6d83a767d4e12c26e6 |
| work_keys_str_mv |
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