Active pulmonary tuberculosis and coronavirus disease 2019: A systematic review and meta-analysis

<h4>Objective</h4> The proportion of COVID-19 patients having active pulmonary tuberculosis, and its impact on COVID-19 related patient outcomes, is not clear. We conducted this systematic review to evaluate the proportion of patients with active pulmonary tuberculosis among COVID-19 pat...

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Autores principales:	Ashutosh Nath Aggarwal, Ritesh Agarwal, Sahajal Dhooria, Kuruswamy Thurai Prasad, Inderpaul Singh Sehgal, Valliappan Muthu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2cdab524eb994168a35413af312820fb
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spelling	oai:doaj.org-article:2cdab524eb994168a35413af312820fb2021-11-04T06:07:14ZActive pulmonary tuberculosis and coronavirus disease 2019: A systematic review and meta-analysis1932-6203https://doaj.org/article/2cdab524eb994168a35413af312820fb2021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8530351/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4> The proportion of COVID-19 patients having active pulmonary tuberculosis, and its impact on COVID-19 related patient outcomes, is not clear. We conducted this systematic review to evaluate the proportion of patients with active pulmonary tuberculosis among COVID-19 patients, and to assess if comorbid pulmonary tuberculosis worsens clinical outcomes in these patients. <h4>Methods</h4> We queried the PubMed and Embase databases for studies providing data on (a) proportion of COVID-19 patients with active pulmonary tuberculosis or (b) severe disease, hospitalization, or mortality among COVID-19 patients with and without active pulmonary tuberculosis. We calculated the proportion of tuberculosis patients, and the relative risk (RR) for each reported outcome of interest. We used random-effects models to summarize our data. <h4>Results</h4> We retrieved 3,375 citations, and included 43 studies, in our review. The pooled estimate for proportion of active pulmonary tuberculosis was 1.07% (95% CI 0.81%-1.36%). COVID-19 patients with tuberculosis had a higher risk of mortality (summary RR 1.93, 95% CI 1.56–2.39, from 17 studies) and for severe COVID-19 disease (summary RR 1.46, 95% CI 1.05–2.02, from 20 studies), but not for hospitalization (summary RR 1.86, 95% CI 0.91–3.81, from four studies), as compared to COVID-19 patients without tuberculosis. <h4>Conclusion</h4> Active pulmonary tuberculosis is relatively common among COVID-19 patients and increases the risk of severe COVID-19 and COVID-19-related mortality.Ashutosh Nath AggarwalRitesh AgarwalSahajal DhooriaKuruswamy Thurai PrasadInderpaul Singh SehgalValliappan MuthuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ashutosh Nath Aggarwal Ritesh Agarwal Sahajal Dhooria Kuruswamy Thurai Prasad Inderpaul Singh Sehgal Valliappan Muthu Active pulmonary tuberculosis and coronavirus disease 2019: A systematic review and meta-analysis
description	<h4>Objective</h4> The proportion of COVID-19 patients having active pulmonary tuberculosis, and its impact on COVID-19 related patient outcomes, is not clear. We conducted this systematic review to evaluate the proportion of patients with active pulmonary tuberculosis among COVID-19 patients, and to assess if comorbid pulmonary tuberculosis worsens clinical outcomes in these patients. <h4>Methods</h4> We queried the PubMed and Embase databases for studies providing data on (a) proportion of COVID-19 patients with active pulmonary tuberculosis or (b) severe disease, hospitalization, or mortality among COVID-19 patients with and without active pulmonary tuberculosis. We calculated the proportion of tuberculosis patients, and the relative risk (RR) for each reported outcome of interest. We used random-effects models to summarize our data. <h4>Results</h4> We retrieved 3,375 citations, and included 43 studies, in our review. The pooled estimate for proportion of active pulmonary tuberculosis was 1.07% (95% CI 0.81%-1.36%). COVID-19 patients with tuberculosis had a higher risk of mortality (summary RR 1.93, 95% CI 1.56–2.39, from 17 studies) and for severe COVID-19 disease (summary RR 1.46, 95% CI 1.05–2.02, from 20 studies), but not for hospitalization (summary RR 1.86, 95% CI 0.91–3.81, from four studies), as compared to COVID-19 patients without tuberculosis. <h4>Conclusion</h4> Active pulmonary tuberculosis is relatively common among COVID-19 patients and increases the risk of severe COVID-19 and COVID-19-related mortality.
format	article
author	Ashutosh Nath Aggarwal Ritesh Agarwal Sahajal Dhooria Kuruswamy Thurai Prasad Inderpaul Singh Sehgal Valliappan Muthu
author_facet	Ashutosh Nath Aggarwal Ritesh Agarwal Sahajal Dhooria Kuruswamy Thurai Prasad Inderpaul Singh Sehgal Valliappan Muthu
author_sort	Ashutosh Nath Aggarwal
title	Active pulmonary tuberculosis and coronavirus disease 2019: A systematic review and meta-analysis
title_short	Active pulmonary tuberculosis and coronavirus disease 2019: A systematic review and meta-analysis
title_full	Active pulmonary tuberculosis and coronavirus disease 2019: A systematic review and meta-analysis
title_fullStr	Active pulmonary tuberculosis and coronavirus disease 2019: A systematic review and meta-analysis
title_full_unstemmed	Active pulmonary tuberculosis and coronavirus disease 2019: A systematic review and meta-analysis
title_sort	active pulmonary tuberculosis and coronavirus disease 2019: a systematic review and meta-analysis
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/2cdab524eb994168a35413af312820fb
work_keys_str_mv	AT ashutoshnathaggarwal activepulmonarytuberculosisandcoronavirusdisease2019asystematicreviewandmetaanalysis AT riteshagarwal activepulmonarytuberculosisandcoronavirusdisease2019asystematicreviewandmetaanalysis AT sahajaldhooria activepulmonarytuberculosisandcoronavirusdisease2019asystematicreviewandmetaanalysis AT kuruswamythuraiprasad activepulmonarytuberculosisandcoronavirusdisease2019asystematicreviewandmetaanalysis AT inderpaulsinghsehgal activepulmonarytuberculosisandcoronavirusdisease2019asystematicreviewandmetaanalysis AT valliappanmuthu activepulmonarytuberculosisandcoronavirusdisease2019asystematicreviewandmetaanalysis
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Active pulmonary tuberculosis and coronavirus disease 2019: A systematic review and meta-analysis

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