The roles and prognostic significance of ABI1-TSV-11 expression in patients with left-sided colorectal cancer

The roles and prognostic significance of ABI1-TSV-11 expression in patients with left-sided colorectal cancer

Abstract Abnormally expressed and/or phosphorylated Abelson interactor 1 (ABI1) participates in the metastasis and progression of colorectal cancer (CRC). ABI1 presents as at least 12 transcript variants (TSVs) by mRNA alternative splicing, but it is unknown which of them is involved in CRC metastas...

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Autores principales: Yu Zhang, Zhaohui Zhong, Mei Li, Jingyi Chen, Tingru Lin, Jie Sun, Di Wang, Qing Mu, Huiting Su, Na Wu, Aiyu Liu, Yimeng Yu, Menglei Zhang, Yulan Liu, Jingzhu Guo, Weidong Yu
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Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/2cdc8a50752b4a388d7082bf563d8433
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spelling oai:doaj.org-article:2cdc8a50752b4a388d7082bf563d84332021-12-02T14:49:18ZThe roles and prognostic significance of ABI1-TSV-11 expression in patients with left-sided colorectal cancer10.1038/s41598-021-90220-82045-2322https://doaj.org/article/2cdc8a50752b4a388d7082bf563d84332021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90220-8https://doaj.org/toc/2045-2322Abstract Abnormally expressed and/or phosphorylated Abelson interactor 1 (ABI1) participates in the metastasis and progression of colorectal cancer (CRC). ABI1 presents as at least 12 transcript variants (TSVs) by mRNA alternative splicing, but it is unknown which of them is involved in CRC metastasis and prognosis. Here, we firstly identified ABI1-TSV-11 as a key TSV affecting the metastasis and prognosis of left-sided colorectal cancer (LsCC) and its elevated expression is related to lymph node metastasis and shorter overall survival (OS) in LsCC by analyzing data from The Cancer Genome Atlas and TSVdb. Secondly, ABI1-TSV-11 overexpression promoted LoVo and SW480 cells adhesion and migration in vitro, and accelerated LoVo and SW480 cells lung metastasis in vivo. Finally, mechanism investigations revealed that ABI1-isoform-11 interacted with epidermal growth factor receptor pathway substrate 8 (ESP8) and regulated actin dynamics to affect LoVo and SW480 cells biological behaviors. Taken together, our data demonstrated that ABI1-TSV-11 plays an oncogenic role in LsCC, it is an independent risk factor of prognosis and may be a potential molecular marker and therapeutic target in LsCC.Yu ZhangZhaohui ZhongMei LiJingyi ChenTingru LinJie SunDi WangQing MuHuiting SuNa WuAiyu LiuYimeng YuMenglei ZhangYulan LiuJingzhu GuoWeidong YuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Yu Zhang
Zhaohui Zhong
Mei Li
Jingyi Chen
Tingru Lin
Jie Sun
Di Wang
Qing Mu
Huiting Su
Na Wu
Aiyu Liu
Yimeng Yu
Menglei Zhang
Yulan Liu
Jingzhu Guo
Weidong Yu
The roles and prognostic significance of ABI1-TSV-11 expression in patients with left-sided colorectal cancer
description Abstract Abnormally expressed and/or phosphorylated Abelson interactor 1 (ABI1) participates in the metastasis and progression of colorectal cancer (CRC). ABI1 presents as at least 12 transcript variants (TSVs) by mRNA alternative splicing, but it is unknown which of them is involved in CRC metastasis and prognosis. Here, we firstly identified ABI1-TSV-11 as a key TSV affecting the metastasis and prognosis of left-sided colorectal cancer (LsCC) and its elevated expression is related to lymph node metastasis and shorter overall survival (OS) in LsCC by analyzing data from The Cancer Genome Atlas and TSVdb. Secondly, ABI1-TSV-11 overexpression promoted LoVo and SW480 cells adhesion and migration in vitro, and accelerated LoVo and SW480 cells lung metastasis in vivo. Finally, mechanism investigations revealed that ABI1-isoform-11 interacted with epidermal growth factor receptor pathway substrate 8 (ESP8) and regulated actin dynamics to affect LoVo and SW480 cells biological behaviors. Taken together, our data demonstrated that ABI1-TSV-11 plays an oncogenic role in LsCC, it is an independent risk factor of prognosis and may be a potential molecular marker and therapeutic target in LsCC.
format article
author Yu Zhang
Zhaohui Zhong
Mei Li
Jingyi Chen
Tingru Lin
Jie Sun
Di Wang
Qing Mu
Huiting Su
Na Wu
Aiyu Liu
Yimeng Yu
Menglei Zhang
Yulan Liu
Jingzhu Guo
Weidong Yu
author_facet Yu Zhang
Zhaohui Zhong
Mei Li
Jingyi Chen
Tingru Lin
Jie Sun
Di Wang
Qing Mu
Huiting Su
Na Wu
Aiyu Liu
Yimeng Yu
Menglei Zhang
Yulan Liu
Jingzhu Guo
Weidong Yu
author_sort Yu Zhang
title The roles and prognostic significance of ABI1-TSV-11 expression in patients with left-sided colorectal cancer
title_short The roles and prognostic significance of ABI1-TSV-11 expression in patients with left-sided colorectal cancer
title_full The roles and prognostic significance of ABI1-TSV-11 expression in patients with left-sided colorectal cancer
title_fullStr The roles and prognostic significance of ABI1-TSV-11 expression in patients with left-sided colorectal cancer
title_full_unstemmed The roles and prognostic significance of ABI1-TSV-11 expression in patients with left-sided colorectal cancer
title_sort roles and prognostic significance of abi1-tsv-11 expression in patients with left-sided colorectal cancer
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/2cdc8a50752b4a388d7082bf563d8433
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