YY1 acts as a transcriptional activator of Hoxa5 gene expression in mouse organogenesis.

The Hox gene family encodes homeodomain-containing transcriptional regulators that confer positional information to axial and paraxial tissues in the developing embryo. The dynamic Hox gene expression pattern requires mechanisms that differentially control Hox transcription in a precise spatio-tempo...

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Autores principales:	Félix-Antoine Bérubé-Simard, Christelle Prudhomme, Lucie Jeannotte
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2cdcac8a52d64c12a50b40ec2536ba48
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spelling	oai:doaj.org-article:2cdcac8a52d64c12a50b40ec2536ba482021-11-18T08:24:46ZYY1 acts as a transcriptional activator of Hoxa5 gene expression in mouse organogenesis.1932-620310.1371/journal.pone.0093989https://doaj.org/article/2cdcac8a52d64c12a50b40ec2536ba482014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24705708/?tool=EBIhttps://doaj.org/toc/1932-6203The Hox gene family encodes homeodomain-containing transcriptional regulators that confer positional information to axial and paraxial tissues in the developing embryo. The dynamic Hox gene expression pattern requires mechanisms that differentially control Hox transcription in a precise spatio-temporal fashion. This implies an integrated regulation of neighbouring Hox genes achieved through the sharing and the selective use of defined enhancer sequences. The Hoxa5 gene plays a crucial role in lung and gut organogenesis. To position Hoxa5 in the regulatory hierarchy that drives organ morphogenesis, we searched for cis-acting regulatory sequences and associated trans-acting factors required for Hoxa5 expression in the developing lung and gut. Using mouse transgenesis, we identified two DNA regions included in a 1.5-kb XbaI-XbaI fragment located in the Hoxa4-Hoxa5 intergenic domain and known to control Hoxa4 organ expression. The multifunctional YY1 transcription factor binds the two regulatory sequences in vitro and in vivo. Moreover, the mesenchymal deletion of the Yy1 gene function in mice results in a Hoxa5-like lung phenotype with decreased Hoxa5 and Hoxa4 gene expression. Thus, YY1 acts as a positive regulator of Hoxa5 expression in the developing lung and gut. Our data also support a role for YY1 in the coordinated expression of Hox genes for correct organogenesis.Félix-Antoine Bérubé-SimardChristelle PrudhommeLucie JeannottePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 4, p e93989 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Félix-Antoine Bérubé-Simard Christelle Prudhomme Lucie Jeannotte YY1 acts as a transcriptional activator of Hoxa5 gene expression in mouse organogenesis.
description	The Hox gene family encodes homeodomain-containing transcriptional regulators that confer positional information to axial and paraxial tissues in the developing embryo. The dynamic Hox gene expression pattern requires mechanisms that differentially control Hox transcription in a precise spatio-temporal fashion. This implies an integrated regulation of neighbouring Hox genes achieved through the sharing and the selective use of defined enhancer sequences. The Hoxa5 gene plays a crucial role in lung and gut organogenesis. To position Hoxa5 in the regulatory hierarchy that drives organ morphogenesis, we searched for cis-acting regulatory sequences and associated trans-acting factors required for Hoxa5 expression in the developing lung and gut. Using mouse transgenesis, we identified two DNA regions included in a 1.5-kb XbaI-XbaI fragment located in the Hoxa4-Hoxa5 intergenic domain and known to control Hoxa4 organ expression. The multifunctional YY1 transcription factor binds the two regulatory sequences in vitro and in vivo. Moreover, the mesenchymal deletion of the Yy1 gene function in mice results in a Hoxa5-like lung phenotype with decreased Hoxa5 and Hoxa4 gene expression. Thus, YY1 acts as a positive regulator of Hoxa5 expression in the developing lung and gut. Our data also support a role for YY1 in the coordinated expression of Hox genes for correct organogenesis.
format	article
author	Félix-Antoine Bérubé-Simard Christelle Prudhomme Lucie Jeannotte
author_facet	Félix-Antoine Bérubé-Simard Christelle Prudhomme Lucie Jeannotte
author_sort	Félix-Antoine Bérubé-Simard
title	YY1 acts as a transcriptional activator of Hoxa5 gene expression in mouse organogenesis.
title_short	YY1 acts as a transcriptional activator of Hoxa5 gene expression in mouse organogenesis.
title_full	YY1 acts as a transcriptional activator of Hoxa5 gene expression in mouse organogenesis.
title_fullStr	YY1 acts as a transcriptional activator of Hoxa5 gene expression in mouse organogenesis.
title_full_unstemmed	YY1 acts as a transcriptional activator of Hoxa5 gene expression in mouse organogenesis.
title_sort	yy1 acts as a transcriptional activator of hoxa5 gene expression in mouse organogenesis.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/2cdcac8a52d64c12a50b40ec2536ba48
work_keys_str_mv	AT felixantoineberubesimard yy1actsasatranscriptionalactivatorofhoxa5geneexpressioninmouseorganogenesis AT christelleprudhomme yy1actsasatranscriptionalactivatorofhoxa5geneexpressioninmouseorganogenesis AT luciejeannotte yy1actsasatranscriptionalactivatorofhoxa5geneexpressioninmouseorganogenesis
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YY1 acts as a transcriptional activator of Hoxa5 gene expression in mouse organogenesis.

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