Epigenetic genes and emotional reactivity to daily life events: a multi-step gene-environment interaction study.

Recent human and animal studies suggest that epigenetic mechanisms mediate the impact of environment on development of mental disorders. Therefore, we hypothesized that polymorphisms in epigenetic-regulatory genes impact stress-induced emotional changes. A multi-step, multi-sample gene-environment i...

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Autores principales:	Ehsan Pishva, Marjan Drukker, Wolfgang Viechtbauer, Jeroen Decoster, Dina Collip, Ruud van Winkel, Marieke Wichers, Nele Jacobs, Evert Thiery, Catherine Derom, Nicole Geschwind, Daniel van den Hove, Tineke Lataster, Inez Myin-Germeys, Jim van Os, Bart P F Rutten, Gunter Kenis
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2cdfe77710b94252a8132c5379b89cbe
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spelling	oai:doaj.org-article:2cdfe77710b94252a8132c5379b89cbe2021-11-11T08:21:27ZEpigenetic genes and emotional reactivity to daily life events: a multi-step gene-environment interaction study.1932-620310.1371/journal.pone.0100935https://doaj.org/article/2cdfe77710b94252a8132c5379b89cbe2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24967710/?tool=EBIhttps://doaj.org/toc/1932-6203Recent human and animal studies suggest that epigenetic mechanisms mediate the impact of environment on development of mental disorders. Therefore, we hypothesized that polymorphisms in epigenetic-regulatory genes impact stress-induced emotional changes. A multi-step, multi-sample gene-environment interaction analysis was conducted to test whether 31 single nucleotide polymorphisms (SNPs) in epigenetic-regulatory genes, i.e. three DNA methyltransferase genes DNMT1, DNMT3A, DNMT3B, and methylenetetrahydrofolate reductase (MTHFR), moderate emotional responses to stressful and pleasant stimuli in daily life as measured by Experience Sampling Methodology (ESM). In the first step, main and interactive effects were tested in a sample of 112 healthy individuals. Significant associations in this discovery sample were then investigated in a population-based sample of 434 individuals for replication. SNPs showing significant effects in both the discovery and replication samples were subsequently tested in three other samples of: (i) 85 unaffected siblings of patients with psychosis, (ii) 110 patients with psychotic disorders, and iii) 126 patients with a history of major depressive disorder. Multilevel linear regression analyses showed no significant association between SNPs and negative affect or positive affect. No SNPs moderated the effect of pleasant stimuli on positive affect. Three SNPs of DNMT3A (rs11683424, rs1465764, rs1465825) and 1 SNP of MTHFR (rs1801131) moderated the effect of stressful events on negative affect. Only rs11683424 of DNMT3A showed consistent directions of effect in the majority of the 5 samples. These data provide the first evidence that emotional responses to daily life stressors may be moderated by genetic variation in the genes involved in the epigenetic machinery.Ehsan PishvaMarjan DrukkerWolfgang ViechtbauerJeroen DecosterDina CollipRuud van WinkelMarieke WichersNele JacobsEvert ThieryCatherine DeromNicole GeschwindDaniel van den HoveTineke LatasterInez Myin-GermeysJim van OsBart P F RuttenGunter KenisPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 6, p e100935 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ehsan Pishva Marjan Drukker Wolfgang Viechtbauer Jeroen Decoster Dina Collip Ruud van Winkel Marieke Wichers Nele Jacobs Evert Thiery Catherine Derom Nicole Geschwind Daniel van den Hove Tineke Lataster Inez Myin-Germeys Jim van Os Bart P F Rutten Gunter Kenis Epigenetic genes and emotional reactivity to daily life events: a multi-step gene-environment interaction study.
description	Recent human and animal studies suggest that epigenetic mechanisms mediate the impact of environment on development of mental disorders. Therefore, we hypothesized that polymorphisms in epigenetic-regulatory genes impact stress-induced emotional changes. A multi-step, multi-sample gene-environment interaction analysis was conducted to test whether 31 single nucleotide polymorphisms (SNPs) in epigenetic-regulatory genes, i.e. three DNA methyltransferase genes DNMT1, DNMT3A, DNMT3B, and methylenetetrahydrofolate reductase (MTHFR), moderate emotional responses to stressful and pleasant stimuli in daily life as measured by Experience Sampling Methodology (ESM). In the first step, main and interactive effects were tested in a sample of 112 healthy individuals. Significant associations in this discovery sample were then investigated in a population-based sample of 434 individuals for replication. SNPs showing significant effects in both the discovery and replication samples were subsequently tested in three other samples of: (i) 85 unaffected siblings of patients with psychosis, (ii) 110 patients with psychotic disorders, and iii) 126 patients with a history of major depressive disorder. Multilevel linear regression analyses showed no significant association between SNPs and negative affect or positive affect. No SNPs moderated the effect of pleasant stimuli on positive affect. Three SNPs of DNMT3A (rs11683424, rs1465764, rs1465825) and 1 SNP of MTHFR (rs1801131) moderated the effect of stressful events on negative affect. Only rs11683424 of DNMT3A showed consistent directions of effect in the majority of the 5 samples. These data provide the first evidence that emotional responses to daily life stressors may be moderated by genetic variation in the genes involved in the epigenetic machinery.
format	article
author	Ehsan Pishva Marjan Drukker Wolfgang Viechtbauer Jeroen Decoster Dina Collip Ruud van Winkel Marieke Wichers Nele Jacobs Evert Thiery Catherine Derom Nicole Geschwind Daniel van den Hove Tineke Lataster Inez Myin-Germeys Jim van Os Bart P F Rutten Gunter Kenis
author_facet	Ehsan Pishva Marjan Drukker Wolfgang Viechtbauer Jeroen Decoster Dina Collip Ruud van Winkel Marieke Wichers Nele Jacobs Evert Thiery Catherine Derom Nicole Geschwind Daniel van den Hove Tineke Lataster Inez Myin-Germeys Jim van Os Bart P F Rutten Gunter Kenis
author_sort	Ehsan Pishva
title	Epigenetic genes and emotional reactivity to daily life events: a multi-step gene-environment interaction study.
title_short	Epigenetic genes and emotional reactivity to daily life events: a multi-step gene-environment interaction study.
title_full	Epigenetic genes and emotional reactivity to daily life events: a multi-step gene-environment interaction study.
title_fullStr	Epigenetic genes and emotional reactivity to daily life events: a multi-step gene-environment interaction study.
title_full_unstemmed	Epigenetic genes and emotional reactivity to daily life events: a multi-step gene-environment interaction study.
title_sort	epigenetic genes and emotional reactivity to daily life events: a multi-step gene-environment interaction study.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/2cdfe77710b94252a8132c5379b89cbe
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Epigenetic genes and emotional reactivity to daily life events: a multi-step gene-environment interaction study.

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