Identification and characterization of a SARS-CoV-2 specific CD8+ T cell response with immunodominant features

Many viral antigens have been identified in patients with COVID-19 patients, but which of these result in meaningful immune responses is unclear. Here the authors identify a range of SARS-CoV-2 CD8+ T cell responses across patients including a response targeting an epitope of ORF1ab with immunodomin...

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Autores principales:	Anastasia Gangaev, Steven L. C. Ketelaars, Olga I. Isaeva, Sanne Patiwael, Anna Dopler, Kelly Hoefakker, Sara De Biasi, Lara Gibellini, Cristina Mussini, Giovanni Guaraldi, Massimo Girardis, Cami M. P. Talavera Ormeno, Paul J. M. Hekking, Neubury M. Lardy, Mireille Toebes, Robert Balderas, Ton N. Schumacher, Huib Ovaa, Andrea Cossarizza, Pia Kvistborg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2ce4c1ed10aa40a0a43f6286be3ee6c6
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spelling	oai:doaj.org-article:2ce4c1ed10aa40a0a43f6286be3ee6c62021-12-02T17:01:35ZIdentification and characterization of a SARS-CoV-2 specific CD8+ T cell response with immunodominant features10.1038/s41467-021-22811-y2041-1723https://doaj.org/article/2ce4c1ed10aa40a0a43f6286be3ee6c62021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22811-yhttps://doaj.org/toc/2041-1723Many viral antigens have been identified in patients with COVID-19 patients, but which of these result in meaningful immune responses is unclear. Here the authors identify a range of SARS-CoV-2 CD8+ T cell responses across patients including a response targeting an epitope of ORF1ab with immunodominant properties.Anastasia GangaevSteven L. C. KetelaarsOlga I. IsaevaSanne PatiwaelAnna DoplerKelly HoefakkerSara De BiasiLara GibelliniCristina MussiniGiovanni GuaraldiMassimo GirardisCami M. P. Talavera OrmenoPaul J. M. HekkingNeubury M. LardyMireille ToebesRobert BalderasTon N. SchumacherHuib OvaaAndrea CossarizzaPia KvistborgNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anastasia Gangaev Steven L. C. Ketelaars Olga I. Isaeva Sanne Patiwael Anna Dopler Kelly Hoefakker Sara De Biasi Lara Gibellini Cristina Mussini Giovanni Guaraldi Massimo Girardis Cami M. P. Talavera Ormeno Paul J. M. Hekking Neubury M. Lardy Mireille Toebes Robert Balderas Ton N. Schumacher Huib Ovaa Andrea Cossarizza Pia Kvistborg Identification and characterization of a SARS-CoV-2 specific CD8+ T cell response with immunodominant features
description	Many viral antigens have been identified in patients with COVID-19 patients, but which of these result in meaningful immune responses is unclear. Here the authors identify a range of SARS-CoV-2 CD8+ T cell responses across patients including a response targeting an epitope of ORF1ab with immunodominant properties.
format	article
author	Anastasia Gangaev Steven L. C. Ketelaars Olga I. Isaeva Sanne Patiwael Anna Dopler Kelly Hoefakker Sara De Biasi Lara Gibellini Cristina Mussini Giovanni Guaraldi Massimo Girardis Cami M. P. Talavera Ormeno Paul J. M. Hekking Neubury M. Lardy Mireille Toebes Robert Balderas Ton N. Schumacher Huib Ovaa Andrea Cossarizza Pia Kvistborg
author_facet	Anastasia Gangaev Steven L. C. Ketelaars Olga I. Isaeva Sanne Patiwael Anna Dopler Kelly Hoefakker Sara De Biasi Lara Gibellini Cristina Mussini Giovanni Guaraldi Massimo Girardis Cami M. P. Talavera Ormeno Paul J. M. Hekking Neubury M. Lardy Mireille Toebes Robert Balderas Ton N. Schumacher Huib Ovaa Andrea Cossarizza Pia Kvistborg
author_sort	Anastasia Gangaev
title	Identification and characterization of a SARS-CoV-2 specific CD8+ T cell response with immunodominant features
title_short	Identification and characterization of a SARS-CoV-2 specific CD8+ T cell response with immunodominant features
title_full	Identification and characterization of a SARS-CoV-2 specific CD8+ T cell response with immunodominant features
title_fullStr	Identification and characterization of a SARS-CoV-2 specific CD8+ T cell response with immunodominant features
title_full_unstemmed	Identification and characterization of a SARS-CoV-2 specific CD8+ T cell response with immunodominant features
title_sort	identification and characterization of a sars-cov-2 specific cd8+ t cell response with immunodominant features
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2ce4c1ed10aa40a0a43f6286be3ee6c6
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Identification and characterization of a SARS-CoV-2 specific CD8+ T cell response with immunodominant features

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