Poly(p-phenylenevinylene) nanoparticles modified with antiEGFRvIII for specific glioblastoma therapy

Abstract Glioblastoma is the most common primary brain cancer and it is nearly impossible to remove the entire tumor with surgery or a single drug. EGFRvIII is the most frequent genetic change associated with glioblastoma, so EGFRvIII-based targeting therapies provide promise for treating glioblasto...

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Autores principales:	Yuchao Liang, Zelin Li, Huanxiang Yuan, Lei Wang, Li-Hua Gao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2ce5baa31adc4a6181a051bf687336d7
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spelling	oai:doaj.org-article:2ce5baa31adc4a6181a051bf687336d72021-12-02T15:53:59ZPoly(p-phenylenevinylene) nanoparticles modified with antiEGFRvIII for specific glioblastoma therapy10.1038/s41598-021-83931-52045-2322https://doaj.org/article/2ce5baa31adc4a6181a051bf687336d72021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83931-5https://doaj.org/toc/2045-2322Abstract Glioblastoma is the most common primary brain cancer and it is nearly impossible to remove the entire tumor with surgery or a single drug. EGFRvIII is the most frequent genetic change associated with glioblastoma, so EGFRvIII-based targeting therapies provide promise for treating glioblastoma. Herein, poly[2-methoxy-5-(2′-ethylhexyloxy)-p-phenylenevinylene] (PPV) was used as the core to prepare a conjugated polymer nanoparticle (PPVN) modified with anti-EGFRvIII (PPVN-A) that exhibited high ROS generation ability under white light irradiation. PPVN-A could target EGFRvIII-overexpressed tumor cells and damaged more than 90% of tumor cells with the light illumination while PPVN without modification exhibited no obvious cytotoxicity toward these cells under the same condition. Thus, the photodynamic treatment of glioblastoma cells using PPVN-A could be achieved, indicating the potential of anti-EGFRvIII-modified nanoparticles as a therapeutic material for treating glioblastoma in clinic.Yuchao LiangZelin LiHuanxiang YuanLei WangLi-Hua GaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yuchao Liang Zelin Li Huanxiang Yuan Lei Wang Li-Hua Gao Poly(p-phenylenevinylene) nanoparticles modified with antiEGFRvIII for specific glioblastoma therapy
description	Abstract Glioblastoma is the most common primary brain cancer and it is nearly impossible to remove the entire tumor with surgery or a single drug. EGFRvIII is the most frequent genetic change associated with glioblastoma, so EGFRvIII-based targeting therapies provide promise for treating glioblastoma. Herein, poly[2-methoxy-5-(2′-ethylhexyloxy)-p-phenylenevinylene] (PPV) was used as the core to prepare a conjugated polymer nanoparticle (PPVN) modified with anti-EGFRvIII (PPVN-A) that exhibited high ROS generation ability under white light irradiation. PPVN-A could target EGFRvIII-overexpressed tumor cells and damaged more than 90% of tumor cells with the light illumination while PPVN without modification exhibited no obvious cytotoxicity toward these cells under the same condition. Thus, the photodynamic treatment of glioblastoma cells using PPVN-A could be achieved, indicating the potential of anti-EGFRvIII-modified nanoparticles as a therapeutic material for treating glioblastoma in clinic.
format	article
author	Yuchao Liang Zelin Li Huanxiang Yuan Lei Wang Li-Hua Gao
author_facet	Yuchao Liang Zelin Li Huanxiang Yuan Lei Wang Li-Hua Gao
author_sort	Yuchao Liang
title	Poly(p-phenylenevinylene) nanoparticles modified with antiEGFRvIII for specific glioblastoma therapy
title_short	Poly(p-phenylenevinylene) nanoparticles modified with antiEGFRvIII for specific glioblastoma therapy
title_full	Poly(p-phenylenevinylene) nanoparticles modified with antiEGFRvIII for specific glioblastoma therapy
title_fullStr	Poly(p-phenylenevinylene) nanoparticles modified with antiEGFRvIII for specific glioblastoma therapy
title_full_unstemmed	Poly(p-phenylenevinylene) nanoparticles modified with antiEGFRvIII for specific glioblastoma therapy
title_sort	poly(p-phenylenevinylene) nanoparticles modified with antiegfrviii for specific glioblastoma therapy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2ce5baa31adc4a6181a051bf687336d7
work_keys_str_mv	AT yuchaoliang polypphenylenevinylenenanoparticlesmodifiedwithantiegfrviiiforspecificglioblastomatherapy AT zelinli polypphenylenevinylenenanoparticlesmodifiedwithantiegfrviiiforspecificglioblastomatherapy AT huanxiangyuan polypphenylenevinylenenanoparticlesmodifiedwithantiegfrviiiforspecificglioblastomatherapy AT leiwang polypphenylenevinylenenanoparticlesmodifiedwithantiegfrviiiforspecificglioblastomatherapy AT lihuagao polypphenylenevinylenenanoparticlesmodifiedwithantiegfrviiiforspecificglioblastomatherapy
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Poly(p-phenylenevinylene) nanoparticles modified with antiEGFRvIII for specific glioblastoma therapy

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