IL 33 Correlates With COVID-19 Severity, Radiographic and Clinical Finding
Objective: The increased level of interleukin (IL)-33 is considered as a predictor of severe coronavirus disease 2019 (COVID-19) infection, but its role at different stages of the disease is still unclear. Our goal was to analyze the correlation of IL-33 and other innate immunity cytokines with dise...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Frontiers Media S.A.
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/2ce6f84dfe2243099f5282bb044d7b50 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:2ce6f84dfe2243099f5282bb044d7b50 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:2ce6f84dfe2243099f5282bb044d7b502021-12-01T16:58:24ZIL 33 Correlates With COVID-19 Severity, Radiographic and Clinical Finding2296-858X10.3389/fmed.2021.749569https://doaj.org/article/2ce6f84dfe2243099f5282bb044d7b502021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.749569/fullhttps://doaj.org/toc/2296-858XObjective: The increased level of interleukin (IL)-33 is considered as a predictor of severe coronavirus disease 2019 (COVID-19) infection, but its role at different stages of the disease is still unclear. Our goal was to analyze the correlation of IL-33 and other innate immunity cytokines with disease severity.Methods: In this study, 220 patients with COVID-19 were included and divided into two groups, mild/moderate and severe/critical. The value of the cytokines, clinical, biochemical, radiographic data was collected and their correlation with disease severity was analyzed.Results: Most patients in the severe/critical group were male (81.8%) and older (over 64.5 years). We found a statistically significant difference (p < 0.05) in these two groups between clinical features (dyspnea, dry cough, fatigue, and auscultatory findings); laboratory [(neutrophil count, lymphocyte count, monocyte count, hemoglobin, plasma glucose, urea, creatinine, total bilirubin (TBIL), direct bilirubin (DBIL), aspartate aminotransferase (AST), albumin (ALB), lactate dehydrogenase (LDH), creatinine kinase (CK), D-dimer, C-reactive protein (CRP), procalcitonin (PCT), Fe, and Ferritin)], arterial blood gases (oxygen saturation-Sa02, partial pressure of oxygen -p02), and chest X-rays (CXR) lung findings (p = 0.000). We found a significantly higher serum concentration (p < 0.05) of TNF-α, IL-1β, IL-6, IL-12, IL-23, and IL-33 in patients with COVID-19 with severe disease. In the milder stage of COVID-19, a positive correlation was detected between IL-33 and IL-1β, IL-12 and IL-23, while a stronger positive correlation between the serum values of IL-33 and TNF-α, IL-1β, IL-6, and IL-12 and IL-23 was detected in patients with COVID-19 with severe disease. A weak negative correlation (p < 0.05) between pO2 and serum IL-1β, IL-12, and IL-33 and between SaO2 and serum IL-33 was noted. The positive relation (p < 0.05) between the serum values of IL-33 and IL-12, IL-33 and IL-6, and IL-6 and IL-12 is proven.Conclusion: In a more progressive stage of COVID-19, increased IL-33 facilitates lung inflammation by inducing the production of various innate proinflammatory cytokines (IL-1β, IL-6, TNF-α, IL-12, and IL-23) in several target cells leading to the most severe forms of the disease. IL-33 correlates with clinical parameters of COVID-19 and might represent a promising marker as well as a therapeutic target in COVID-19.Sofija Sekulic MarkovicMarina JovanovicNevena GajovicMilena JurisevicNebojsa ArsenijevicNebojsa ArsenijevicMarina JovanovicMilan JovanovicZeljko MijailovicSnezana LukicNenad ZornicVladimir VukicevicJasmina StojanovicVeljko MaricMiodrag JocicIvan JovanovicFrontiers Media S.A.articleIL 33COVID-19disease severitycorrelationproinflammatory innate immune responseMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
IL 33 COVID-19 disease severity correlation proinflammatory innate immune response Medicine (General) R5-920 |
| spellingShingle |
IL 33 COVID-19 disease severity correlation proinflammatory innate immune response Medicine (General) R5-920 Sofija Sekulic Markovic Marina Jovanovic Nevena Gajovic Milena Jurisevic Nebojsa Arsenijevic Nebojsa Arsenijevic Marina Jovanovic Milan Jovanovic Zeljko Mijailovic Snezana Lukic Nenad Zornic Vladimir Vukicevic Jasmina Stojanovic Veljko Maric Miodrag Jocic Ivan Jovanovic IL 33 Correlates With COVID-19 Severity, Radiographic and Clinical Finding |
| description |
Objective: The increased level of interleukin (IL)-33 is considered as a predictor of severe coronavirus disease 2019 (COVID-19) infection, but its role at different stages of the disease is still unclear. Our goal was to analyze the correlation of IL-33 and other innate immunity cytokines with disease severity.Methods: In this study, 220 patients with COVID-19 were included and divided into two groups, mild/moderate and severe/critical. The value of the cytokines, clinical, biochemical, radiographic data was collected and their correlation with disease severity was analyzed.Results: Most patients in the severe/critical group were male (81.8%) and older (over 64.5 years). We found a statistically significant difference (p < 0.05) in these two groups between clinical features (dyspnea, dry cough, fatigue, and auscultatory findings); laboratory [(neutrophil count, lymphocyte count, monocyte count, hemoglobin, plasma glucose, urea, creatinine, total bilirubin (TBIL), direct bilirubin (DBIL), aspartate aminotransferase (AST), albumin (ALB), lactate dehydrogenase (LDH), creatinine kinase (CK), D-dimer, C-reactive protein (CRP), procalcitonin (PCT), Fe, and Ferritin)], arterial blood gases (oxygen saturation-Sa02, partial pressure of oxygen -p02), and chest X-rays (CXR) lung findings (p = 0.000). We found a significantly higher serum concentration (p < 0.05) of TNF-α, IL-1β, IL-6, IL-12, IL-23, and IL-33 in patients with COVID-19 with severe disease. In the milder stage of COVID-19, a positive correlation was detected between IL-33 and IL-1β, IL-12 and IL-23, while a stronger positive correlation between the serum values of IL-33 and TNF-α, IL-1β, IL-6, and IL-12 and IL-23 was detected in patients with COVID-19 with severe disease. A weak negative correlation (p < 0.05) between pO2 and serum IL-1β, IL-12, and IL-33 and between SaO2 and serum IL-33 was noted. The positive relation (p < 0.05) between the serum values of IL-33 and IL-12, IL-33 and IL-6, and IL-6 and IL-12 is proven.Conclusion: In a more progressive stage of COVID-19, increased IL-33 facilitates lung inflammation by inducing the production of various innate proinflammatory cytokines (IL-1β, IL-6, TNF-α, IL-12, and IL-23) in several target cells leading to the most severe forms of the disease. IL-33 correlates with clinical parameters of COVID-19 and might represent a promising marker as well as a therapeutic target in COVID-19. |
| format |
article |
| author |
Sofija Sekulic Markovic Marina Jovanovic Nevena Gajovic Milena Jurisevic Nebojsa Arsenijevic Nebojsa Arsenijevic Marina Jovanovic Milan Jovanovic Zeljko Mijailovic Snezana Lukic Nenad Zornic Vladimir Vukicevic Jasmina Stojanovic Veljko Maric Miodrag Jocic Ivan Jovanovic |
| author_facet |
Sofija Sekulic Markovic Marina Jovanovic Nevena Gajovic Milena Jurisevic Nebojsa Arsenijevic Nebojsa Arsenijevic Marina Jovanovic Milan Jovanovic Zeljko Mijailovic Snezana Lukic Nenad Zornic Vladimir Vukicevic Jasmina Stojanovic Veljko Maric Miodrag Jocic Ivan Jovanovic |
| author_sort |
Sofija Sekulic Markovic |
| title |
IL 33 Correlates With COVID-19 Severity, Radiographic and Clinical Finding |
| title_short |
IL 33 Correlates With COVID-19 Severity, Radiographic and Clinical Finding |
| title_full |
IL 33 Correlates With COVID-19 Severity, Radiographic and Clinical Finding |
| title_fullStr |
IL 33 Correlates With COVID-19 Severity, Radiographic and Clinical Finding |
| title_full_unstemmed |
IL 33 Correlates With COVID-19 Severity, Radiographic and Clinical Finding |
| title_sort |
il 33 correlates with covid-19 severity, radiographic and clinical finding |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/2ce6f84dfe2243099f5282bb044d7b50 |
| work_keys_str_mv |
AT sofijasekulicmarkovic il33correlateswithcovid19severityradiographicandclinicalfinding AT marinajovanovic il33correlateswithcovid19severityradiographicandclinicalfinding AT nevenagajovic il33correlateswithcovid19severityradiographicandclinicalfinding AT milenajurisevic il33correlateswithcovid19severityradiographicandclinicalfinding AT nebojsaarsenijevic il33correlateswithcovid19severityradiographicandclinicalfinding AT nebojsaarsenijevic il33correlateswithcovid19severityradiographicandclinicalfinding AT marinajovanovic il33correlateswithcovid19severityradiographicandclinicalfinding AT milanjovanovic il33correlateswithcovid19severityradiographicandclinicalfinding AT zeljkomijailovic il33correlateswithcovid19severityradiographicandclinicalfinding AT snezanalukic il33correlateswithcovid19severityradiographicandclinicalfinding AT nenadzornic il33correlateswithcovid19severityradiographicandclinicalfinding AT vladimirvukicevic il33correlateswithcovid19severityradiographicandclinicalfinding AT jasminastojanovic il33correlateswithcovid19severityradiographicandclinicalfinding AT veljkomaric il33correlateswithcovid19severityradiographicandclinicalfinding AT miodragjocic il33correlateswithcovid19severityradiographicandclinicalfinding AT ivanjovanovic il33correlateswithcovid19severityradiographicandclinicalfinding |
| _version_ |
1718404740533977088 |