Incidence and predictors of mortality among children co-infected with tuberculosis and human immunodeficiency virus at public hospitals in Southern Ethiopia.

<h4>Background</h4>Tuberculosis and human immune deficiency virus co-infections remained the most common cause of child mortality for the last ten years. Globally, 1.2 million cases of tuberculosis occurred in patients living with HIV/AIDS, of which 1.0 million cases occurred in children...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zinabu Dawit, Sintayehu Abebe, Samuel Dessu, Molalegn Mesele, Serekebirhan Sahile, Desalegn Ajema
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2ce8c569d07e4ec09d014220e38c3de9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2ce8c569d07e4ec09d014220e38c3de9
record_format	dspace
spelling	oai:doaj.org-article:2ce8c569d07e4ec09d014220e38c3de92021-12-02T20:15:43ZIncidence and predictors of mortality among children co-infected with tuberculosis and human immunodeficiency virus at public hospitals in Southern Ethiopia.1932-620310.1371/journal.pone.0253449https://doaj.org/article/2ce8c569d07e4ec09d014220e38c3de92021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253449https://doaj.org/toc/1932-6203<h4>Background</h4>Tuberculosis and human immune deficiency virus co-infections remained the most common cause of child mortality for the last ten years. Globally, 1.2 million cases of tuberculosis occurred in patients living with HIV/AIDS, of which 1.0 million cases occurred in children. The public health impact of tuberculosis and human immune deficiency virus co-infection among children is high in developing countries and Sub-Saharan Africa accompanied three fourth of the global burden. However, there are limited studies that assess the incidence and predictors of mortality among tuberculosis and human immune deficiency virus co-infected children in Ethiopia.<h4>Methods</h4>A facility-based retrospective cohort study was conducted at Public hospitals in Southern Ethiopia with a total of 286 randomly selected records of ART enrolled children from 1st January 2009 to 31stDecember 2018. Data were entered into Epi Data version 3.1 and exported to STATA version 14 for analysis. Bivariate and multivariable Cox proportional hazards model was fitted to identify the predictors of mortality. Variables that had a p-value<0.05 at 95%CI in the multivariable cox proportional hazard model were considered as statistically significant.<h4>Results</h4>A total of 274 tuberculosis and human immunodeficiency virus co-infected children's records were reviewed. The incidence of mortality among tuberculosis and human immunodeficiency virus co-infected children was 17.15 per 100 children. The overall incidence density rate of mortality was 2.97(95%CI: 2.2, 3.9) per 100 child year of observation and being anemic (AHR: 2.6; 95%CI: 1.28, 5.21), not initiating isoniazid prophylaxis therapy (AHR: 2.8; 95%CI: 1.44, 5.48), developing extrapulmonary tuberculosis (AHR: 5.7; 95%CI: 2.67, 12.56) and non-adherence (AHR: 5.2; 95%CI: 2.19, 12.39) were independent predictors of mortality.<h4>Conclusion</h4>Mortality rate was high among TB/HIV co-infected children at the public hospitals in Southern Ethiopia. Extra-pulmonary tuberculosis, anemia, non-adherence, and isoniazid preventive therapy use were statistically significant predictors of mortality among TB/HIV co-infected children. Therefore, extra pulmonary tuberculosis, and anemia should be closely monitored to increase their adherence as well as they should be provided with isoniazid preventive therapy.Zinabu DawitSintayehu AbebeSamuel DessuMolalegn MeseleSerekebirhan SahileDesalegn AjemaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0253449 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zinabu Dawit Sintayehu Abebe Samuel Dessu Molalegn Mesele Serekebirhan Sahile Desalegn Ajema Incidence and predictors of mortality among children co-infected with tuberculosis and human immunodeficiency virus at public hospitals in Southern Ethiopia.
description	<h4>Background</h4>Tuberculosis and human immune deficiency virus co-infections remained the most common cause of child mortality for the last ten years. Globally, 1.2 million cases of tuberculosis occurred in patients living with HIV/AIDS, of which 1.0 million cases occurred in children. The public health impact of tuberculosis and human immune deficiency virus co-infection among children is high in developing countries and Sub-Saharan Africa accompanied three fourth of the global burden. However, there are limited studies that assess the incidence and predictors of mortality among tuberculosis and human immune deficiency virus co-infected children in Ethiopia.<h4>Methods</h4>A facility-based retrospective cohort study was conducted at Public hospitals in Southern Ethiopia with a total of 286 randomly selected records of ART enrolled children from 1st January 2009 to 31stDecember 2018. Data were entered into Epi Data version 3.1 and exported to STATA version 14 for analysis. Bivariate and multivariable Cox proportional hazards model was fitted to identify the predictors of mortality. Variables that had a p-value<0.05 at 95%CI in the multivariable cox proportional hazard model were considered as statistically significant.<h4>Results</h4>A total of 274 tuberculosis and human immunodeficiency virus co-infected children's records were reviewed. The incidence of mortality among tuberculosis and human immunodeficiency virus co-infected children was 17.15 per 100 children. The overall incidence density rate of mortality was 2.97(95%CI: 2.2, 3.9) per 100 child year of observation and being anemic (AHR: 2.6; 95%CI: 1.28, 5.21), not initiating isoniazid prophylaxis therapy (AHR: 2.8; 95%CI: 1.44, 5.48), developing extrapulmonary tuberculosis (AHR: 5.7; 95%CI: 2.67, 12.56) and non-adherence (AHR: 5.2; 95%CI: 2.19, 12.39) were independent predictors of mortality.<h4>Conclusion</h4>Mortality rate was high among TB/HIV co-infected children at the public hospitals in Southern Ethiopia. Extra-pulmonary tuberculosis, anemia, non-adherence, and isoniazid preventive therapy use were statistically significant predictors of mortality among TB/HIV co-infected children. Therefore, extra pulmonary tuberculosis, and anemia should be closely monitored to increase their adherence as well as they should be provided with isoniazid preventive therapy.
format	article
author	Zinabu Dawit Sintayehu Abebe Samuel Dessu Molalegn Mesele Serekebirhan Sahile Desalegn Ajema
author_facet	Zinabu Dawit Sintayehu Abebe Samuel Dessu Molalegn Mesele Serekebirhan Sahile Desalegn Ajema
author_sort	Zinabu Dawit
title	Incidence and predictors of mortality among children co-infected with tuberculosis and human immunodeficiency virus at public hospitals in Southern Ethiopia.
title_short	Incidence and predictors of mortality among children co-infected with tuberculosis and human immunodeficiency virus at public hospitals in Southern Ethiopia.
title_full	Incidence and predictors of mortality among children co-infected with tuberculosis and human immunodeficiency virus at public hospitals in Southern Ethiopia.
title_fullStr	Incidence and predictors of mortality among children co-infected with tuberculosis and human immunodeficiency virus at public hospitals in Southern Ethiopia.
title_full_unstemmed	Incidence and predictors of mortality among children co-infected with tuberculosis and human immunodeficiency virus at public hospitals in Southern Ethiopia.
title_sort	incidence and predictors of mortality among children co-infected with tuberculosis and human immunodeficiency virus at public hospitals in southern ethiopia.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/2ce8c569d07e4ec09d014220e38c3de9
work_keys_str_mv	AT zinabudawit incidenceandpredictorsofmortalityamongchildrencoinfectedwithtuberculosisandhumanimmunodeficiencyvirusatpublichospitalsinsouthernethiopia AT sintayehuabebe incidenceandpredictorsofmortalityamongchildrencoinfectedwithtuberculosisandhumanimmunodeficiencyvirusatpublichospitalsinsouthernethiopia AT samueldessu incidenceandpredictorsofmortalityamongchildrencoinfectedwithtuberculosisandhumanimmunodeficiencyvirusatpublichospitalsinsouthernethiopia AT molalegnmesele incidenceandpredictorsofmortalityamongchildrencoinfectedwithtuberculosisandhumanimmunodeficiencyvirusatpublichospitalsinsouthernethiopia AT serekebirhansahile incidenceandpredictorsofmortalityamongchildrencoinfectedwithtuberculosisandhumanimmunodeficiencyvirusatpublichospitalsinsouthernethiopia AT desalegnajema incidenceandpredictorsofmortalityamongchildrencoinfectedwithtuberculosisandhumanimmunodeficiencyvirusatpublichospitalsinsouthernethiopia
_version_	1718374515149373440

Incidence and predictors of mortality among children co-infected with tuberculosis and human immunodeficiency virus at public hospitals in Southern Ethiopia.

Ejemplares similares