The Role of Selected Pro-Inflammatory Cytokines in Pathogenesis of Ischemic Stroke

Hanna Pawluk,1 Alina Woźniak,1 Grzegorz Grześk,2 Renata Kołodziejska,1 Mariusz Kozakiewicz,3 Ewa Kopkowska,1 Elżbieta Grzechowiak,4 Grzegorz Kozera4,5 1Department of Medical Biology and Biochemistry, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgos...

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Autores principales:	Pawluk H, Woźniak A, Grześk G, Kołodziejska R, Kozakiewicz M, Kopkowska E, Grzechowiak E, Kozera G
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	cytokines ischemic stroke old age disease Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/2ce97e145a36433cad79c7937b0587ed
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spelling	oai:doaj.org-article:2ce97e145a36433cad79c7937b0587ed2021-12-02T10:08:28ZThe Role of Selected Pro-Inflammatory Cytokines in Pathogenesis of Ischemic Stroke1178-1998https://doaj.org/article/2ce97e145a36433cad79c7937b0587ed2020-03-01T00:00:00Zhttps://www.dovepress.com/the-role-of-selected-pro-inflammatory-cytokines-in-pathogenesis-of-isc-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Hanna Pawluk,1 Alina Woźniak,1 Grzegorz Grześk,2 Renata Kołodziejska,1 Mariusz Kozakiewicz,3 Ewa Kopkowska,1 Elżbieta Grzechowiak,4 Grzegorz Kozera4,5 1Department of Medical Biology and Biochemistry, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland; 2 2nd Department of Cardiology, Faculty of Health Sciences, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland; 3Department of Geriatrics, Division of Biochemistry and Biogerontology, Faculty of Health Sciences, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland; 4Department of Neurology, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland; 5Medical Stimulation Center, Medical University of Gdańsk, Gdańsk, PolandCorrespondence: Hanna PawlukDepartment of Medical Biology and Biochemistry, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Karłowicza 24, Bydgoszcz 85– 092, PolandTel +48 52 585 37 55Email hannapawluk1@wp.plAbstract: Stroke is currently one of the most common causes of death and disability in the world, and its pathophysiology is a complex process, involving the oxidative stress and inflammatory reaction. Unfortunately, no biochemical factors useful in the diagnostics and treatment of stroke have been clearly established to date. Therefore, researchers are increasingly interested in the inflammatory response triggered by cerebral ischemia and its role in the development of cerebral infarction. This article gives an overview of the available literature data concerning the role of pro-inflammatory cytokines in acute stroke. Detailed analysis of their role in cerebral circulation disturbances can also suggest certain immune response regulatory mechanisms aimed to reduce damage to the nervous tissue in the course of stroke.Keywords: cytokines, ischemic stroke, old age diseasePawluk HWoźniak AGrześk GKołodziejska RKozakiewicz MKopkowska EGrzechowiak EKozera GDove Medical Pressarticlecytokinesischemic strokeold age diseaseGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 15, Pp 469-484 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	cytokines ischemic stroke old age disease Geriatrics RC952-954.6
spellingShingle	cytokines ischemic stroke old age disease Geriatrics RC952-954.6 Pawluk H Woźniak A Grześk G Kołodziejska R Kozakiewicz M Kopkowska E Grzechowiak E Kozera G The Role of Selected Pro-Inflammatory Cytokines in Pathogenesis of Ischemic Stroke
description	Hanna Pawluk,1 Alina Woźniak,1 Grzegorz Grześk,2 Renata Kołodziejska,1 Mariusz Kozakiewicz,3 Ewa Kopkowska,1 Elżbieta Grzechowiak,4 Grzegorz Kozera4,5 1Department of Medical Biology and Biochemistry, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland; 2 2nd Department of Cardiology, Faculty of Health Sciences, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland; 3Department of Geriatrics, Division of Biochemistry and Biogerontology, Faculty of Health Sciences, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland; 4Department of Neurology, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland; 5Medical Stimulation Center, Medical University of Gdańsk, Gdańsk, PolandCorrespondence: Hanna PawlukDepartment of Medical Biology and Biochemistry, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Karłowicza 24, Bydgoszcz 85– 092, PolandTel +48 52 585 37 55Email hannapawluk1@wp.plAbstract: Stroke is currently one of the most common causes of death and disability in the world, and its pathophysiology is a complex process, involving the oxidative stress and inflammatory reaction. Unfortunately, no biochemical factors useful in the diagnostics and treatment of stroke have been clearly established to date. Therefore, researchers are increasingly interested in the inflammatory response triggered by cerebral ischemia and its role in the development of cerebral infarction. This article gives an overview of the available literature data concerning the role of pro-inflammatory cytokines in acute stroke. Detailed analysis of their role in cerebral circulation disturbances can also suggest certain immune response regulatory mechanisms aimed to reduce damage to the nervous tissue in the course of stroke.Keywords: cytokines, ischemic stroke, old age disease
format	article
author	Pawluk H Woźniak A Grześk G Kołodziejska R Kozakiewicz M Kopkowska E Grzechowiak E Kozera G
author_facet	Pawluk H Woźniak A Grześk G Kołodziejska R Kozakiewicz M Kopkowska E Grzechowiak E Kozera G
author_sort	Pawluk H
title	The Role of Selected Pro-Inflammatory Cytokines in Pathogenesis of Ischemic Stroke
title_short	The Role of Selected Pro-Inflammatory Cytokines in Pathogenesis of Ischemic Stroke
title_full	The Role of Selected Pro-Inflammatory Cytokines in Pathogenesis of Ischemic Stroke
title_fullStr	The Role of Selected Pro-Inflammatory Cytokines in Pathogenesis of Ischemic Stroke
title_full_unstemmed	The Role of Selected Pro-Inflammatory Cytokines in Pathogenesis of Ischemic Stroke
title_sort	role of selected pro-inflammatory cytokines in pathogenesis of ischemic stroke
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/2ce97e145a36433cad79c7937b0587ed
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The Role of Selected Pro-Inflammatory Cytokines in Pathogenesis of Ischemic Stroke

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