Histone Lysine Methylation and Long Non-Coding RNA: The New Target Players in Skeletal Muscle Cell Regeneration

Satellite stem cell availability and high regenerative capacity have made them an ideal therapeutic approach for muscular dystrophies and neuromuscular diseases. Adult satellite stem cells remain in a quiescent state and become activated upon muscular injury. A series of molecular mechanisms succeed...

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Autores principales:	Magdaleena Naemi Mbadhi, Jun-ming Tang, Jing-xuan Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	epigenetics skeletal muscle skeletal muscle regeneration histone methylation lncRNAs satellite stem cells Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/2ceae69514a34778bb049b0324633a9c
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spelling	oai:doaj.org-article:2ceae69514a34778bb049b0324633a9c2021-12-03T05:49:00ZHistone Lysine Methylation and Long Non-Coding RNA: The New Target Players in Skeletal Muscle Cell Regeneration2296-634X10.3389/fcell.2021.759237https://doaj.org/article/2ceae69514a34778bb049b0324633a9c2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.759237/fullhttps://doaj.org/toc/2296-634XSatellite stem cell availability and high regenerative capacity have made them an ideal therapeutic approach for muscular dystrophies and neuromuscular diseases. Adult satellite stem cells remain in a quiescent state and become activated upon muscular injury. A series of molecular mechanisms succeed under the control of epigenetic regulation and various myogenic regulatory transcription factors myogenic regulatory factors, leading to their differentiation into skeletal muscles. The regulation of MRFs via various epigenetic factors, including DNA methylation, histone modification, and non-coding RNA, determine the fate of myogenesis. Furthermore, the development of histone deacetylation inhibitors (HDACi) has shown promising benefits in their use in clinical trials of muscular diseases. However, the complete application of using satellite stem cells in the clinic is still not achieved. While therapeutic advancements in the use of HDACi in clinical trials have emerged, histone methylation modulations and the long non-coding RNA (lncRNA) are still under study. A comprehensive understanding of these other significant epigenetic modulations is still incomplete. This review aims to discuss some of the current studies on these two significant epigenetic modulations, histone methylation and lncRNA, as potential epigenetic targets in skeletal muscle regeneration. Understanding the mechanisms that initiate myoblast differentiation from its proliferative state to generate new muscle fibres will provide valuable information to advance the field of regenerative medicine and stem cell transplant.Magdaleena Naemi MbadhiJun-ming TangJing-xuan ZhangFrontiers Media S.A.articleepigeneticsskeletal muscleskeletal muscle regenerationhistone methylationlncRNAssatellite stem cellsBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	epigenetics skeletal muscle skeletal muscle regeneration histone methylation lncRNAs satellite stem cells Biology (General) QH301-705.5
spellingShingle	epigenetics skeletal muscle skeletal muscle regeneration histone methylation lncRNAs satellite stem cells Biology (General) QH301-705.5 Magdaleena Naemi Mbadhi Jun-ming Tang Jing-xuan Zhang Histone Lysine Methylation and Long Non-Coding RNA: The New Target Players in Skeletal Muscle Cell Regeneration
description	Satellite stem cell availability and high regenerative capacity have made them an ideal therapeutic approach for muscular dystrophies and neuromuscular diseases. Adult satellite stem cells remain in a quiescent state and become activated upon muscular injury. A series of molecular mechanisms succeed under the control of epigenetic regulation and various myogenic regulatory transcription factors myogenic regulatory factors, leading to their differentiation into skeletal muscles. The regulation of MRFs via various epigenetic factors, including DNA methylation, histone modification, and non-coding RNA, determine the fate of myogenesis. Furthermore, the development of histone deacetylation inhibitors (HDACi) has shown promising benefits in their use in clinical trials of muscular diseases. However, the complete application of using satellite stem cells in the clinic is still not achieved. While therapeutic advancements in the use of HDACi in clinical trials have emerged, histone methylation modulations and the long non-coding RNA (lncRNA) are still under study. A comprehensive understanding of these other significant epigenetic modulations is still incomplete. This review aims to discuss some of the current studies on these two significant epigenetic modulations, histone methylation and lncRNA, as potential epigenetic targets in skeletal muscle regeneration. Understanding the mechanisms that initiate myoblast differentiation from its proliferative state to generate new muscle fibres will provide valuable information to advance the field of regenerative medicine and stem cell transplant.
format	article
author	Magdaleena Naemi Mbadhi Jun-ming Tang Jing-xuan Zhang
author_facet	Magdaleena Naemi Mbadhi Jun-ming Tang Jing-xuan Zhang
author_sort	Magdaleena Naemi Mbadhi
title	Histone Lysine Methylation and Long Non-Coding RNA: The New Target Players in Skeletal Muscle Cell Regeneration
title_short	Histone Lysine Methylation and Long Non-Coding RNA: The New Target Players in Skeletal Muscle Cell Regeneration
title_full	Histone Lysine Methylation and Long Non-Coding RNA: The New Target Players in Skeletal Muscle Cell Regeneration
title_fullStr	Histone Lysine Methylation and Long Non-Coding RNA: The New Target Players in Skeletal Muscle Cell Regeneration
title_full_unstemmed	Histone Lysine Methylation and Long Non-Coding RNA: The New Target Players in Skeletal Muscle Cell Regeneration
title_sort	histone lysine methylation and long non-coding rna: the new target players in skeletal muscle cell regeneration
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/2ceae69514a34778bb049b0324633a9c
work_keys_str_mv	AT magdaleenanaemimbadhi histonelysinemethylationandlongnoncodingrnathenewtargetplayersinskeletalmusclecellregeneration AT junmingtang histonelysinemethylationandlongnoncodingrnathenewtargetplayersinskeletalmusclecellregeneration AT jingxuanzhang histonelysinemethylationandlongnoncodingrnathenewtargetplayersinskeletalmusclecellregeneration
_version_	1718373862520913920

Histone Lysine Methylation and Long Non-Coding RNA: The New Target Players in Skeletal Muscle Cell Regeneration

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