Inherited salt-losing tubulopathies are associated with immunodeficiency due to impaired IL-17 responses

Salt levels in culture affect the polarisation of Th17 cells, which normally protect the host from fungal and bacterial infections. Here, the authors study patients with salt-losing tubulopathies (SLT) to find that, while Th17 immunity is dampened in SLT patients, their Th17-inducing signaling pathw...

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Autores principales:	Rhys D. R. Evans, Marilina Antonelou, Sanchutha Sathiananthamoorthy, Marilena Rega, Scott Henderson, Lourdes Ceron-Gutierrez, Gabriela Barcenas-Morales, Christoph A. Müller, Rainer Doffinger, Stephen B. Walsh, Alan D. Salama
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2cec9c8266184037b9f92780094ab2b6
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spelling	oai:doaj.org-article:2cec9c8266184037b9f92780094ab2b62021-12-02T19:09:31ZInherited salt-losing tubulopathies are associated with immunodeficiency due to impaired IL-17 responses10.1038/s41467-020-18184-32041-1723https://doaj.org/article/2cec9c8266184037b9f92780094ab2b62020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18184-3https://doaj.org/toc/2041-1723Salt levels in culture affect the polarisation of Th17 cells, which normally protect the host from fungal and bacterial infections. Here, the authors study patients with salt-losing tubulopathies (SLT) to find that, while Th17 immunity is dampened in SLT patients, their Th17-inducing signaling pathways are intact and can be reinvigorated by exogenous salt.Rhys D. R. EvansMarilina AntonelouSanchutha SathiananthamoorthyMarilena RegaScott HendersonLourdes Ceron-GutierrezGabriela Barcenas-MoralesChristoph A. MüllerRainer DoffingerStephen B. WalshAlan D. SalamaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rhys D. R. Evans Marilina Antonelou Sanchutha Sathiananthamoorthy Marilena Rega Scott Henderson Lourdes Ceron-Gutierrez Gabriela Barcenas-Morales Christoph A. Müller Rainer Doffinger Stephen B. Walsh Alan D. Salama Inherited salt-losing tubulopathies are associated with immunodeficiency due to impaired IL-17 responses
description	Salt levels in culture affect the polarisation of Th17 cells, which normally protect the host from fungal and bacterial infections. Here, the authors study patients with salt-losing tubulopathies (SLT) to find that, while Th17 immunity is dampened in SLT patients, their Th17-inducing signaling pathways are intact and can be reinvigorated by exogenous salt.
format	article
author	Rhys D. R. Evans Marilina Antonelou Sanchutha Sathiananthamoorthy Marilena Rega Scott Henderson Lourdes Ceron-Gutierrez Gabriela Barcenas-Morales Christoph A. Müller Rainer Doffinger Stephen B. Walsh Alan D. Salama
author_facet	Rhys D. R. Evans Marilina Antonelou Sanchutha Sathiananthamoorthy Marilena Rega Scott Henderson Lourdes Ceron-Gutierrez Gabriela Barcenas-Morales Christoph A. Müller Rainer Doffinger Stephen B. Walsh Alan D. Salama
author_sort	Rhys D. R. Evans
title	Inherited salt-losing tubulopathies are associated with immunodeficiency due to impaired IL-17 responses
title_short	Inherited salt-losing tubulopathies are associated with immunodeficiency due to impaired IL-17 responses
title_full	Inherited salt-losing tubulopathies are associated with immunodeficiency due to impaired IL-17 responses
title_fullStr	Inherited salt-losing tubulopathies are associated with immunodeficiency due to impaired IL-17 responses
title_full_unstemmed	Inherited salt-losing tubulopathies are associated with immunodeficiency due to impaired IL-17 responses
title_sort	inherited salt-losing tubulopathies are associated with immunodeficiency due to impaired il-17 responses
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/2cec9c8266184037b9f92780094ab2b6
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Inherited salt-losing tubulopathies are associated with immunodeficiency due to impaired IL-17 responses

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