Inherited salt-losing tubulopathies are associated with immunodeficiency due to impaired IL-17 responses
Salt levels in culture affect the polarisation of Th17 cells, which normally protect the host from fungal and bacterial infections. Here, the authors study patients with salt-losing tubulopathies (SLT) to find that, while Th17 immunity is dampened in SLT patients, their Th17-inducing signaling pathw...
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Main Authors: | Rhys D. R. Evans, Marilina Antonelou, Sanchutha Sathiananthamoorthy, Marilena Rega, Scott Henderson, Lourdes Ceron-Gutierrez, Gabriela Barcenas-Morales, Christoph A. Müller, Rainer Doffinger, Stephen B. Walsh, Alan D. Salama |
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Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2020
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Online Access: | https://doaj.org/article/2cec9c8266184037b9f92780094ab2b6 |
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