Molecular Mechanisms of Muscle Fatigue

Muscle fatigue (MF) declines the capacity of muscles to complete a task over time at a constant load. MF is usually short-lasting, reversible, and is experienced as a feeling of tiredness or lack of energy. The leading causes of short-lasting fatigue are related to overtraining, undertraining/decond...

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Autores principales:	Dumitru Constantin-Teodosiu, Despina Constantin
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	skeletal muscle atrophy muscle function fatigue Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/2cf70f3afb8644a5a7aab84b98cafc39
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spelling	oai:doaj.org-article:2cf70f3afb8644a5a7aab84b98cafc392021-11-11T17:04:10ZMolecular Mechanisms of Muscle Fatigue10.3390/ijms2221115871422-00671661-6596https://doaj.org/article/2cf70f3afb8644a5a7aab84b98cafc392021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11587https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Muscle fatigue (MF) declines the capacity of muscles to complete a task over time at a constant load. MF is usually short-lasting, reversible, and is experienced as a feeling of tiredness or lack of energy. The leading causes of short-lasting fatigue are related to overtraining, undertraining/deconditioning, or physical injury. Conversely, MF can be persistent and more serious when associated with pathological states or following chronic exposure to certain medication or toxic composites. In conjunction with chronic fatigue, the muscle feels floppy, and the force generated by muscles is always low, causing the individual to feel frail constantly. The leading cause underpinning the development of chronic fatigue is related to muscle wasting mediated by aging, immobilization, insulin resistance (through high-fat dietary intake or pharmacologically mediated Peroxisome Proliferator-Activated Receptor (PPAR) agonism), diseases associated with systemic inflammation (arthritis, sepsis, infections, trauma, cardiovascular and respiratory disorders (heart failure, chronic obstructive pulmonary disease (COPD))), chronic kidney failure, muscle dystrophies, muscle myopathies, multiple sclerosis, and, more recently, coronavirus disease 2019 (COVID-19). The primary outcome of displaying chronic muscle fatigue is a poor quality of life. This type of fatigue represents a significant daily challenge for those affected and for the national health authorities through the financial burden attached to patient support. Although the origin of chronic fatigue is multifactorial, the MF in illness conditions is intrinsically linked to the occurrence of muscle loss. The sequence of events leading to chronic fatigue can be schematically denoted as: trigger (genetic or pathological) -> molecular outcome within the muscle cell -> muscle wasting -> loss of muscle function -> occurrence of chronic muscle fatigue. The present review will only highlight and discuss current knowledge on the molecular mechanisms that contribute to the upregulation of muscle wasting, thereby helping us understand how we could prevent or treat this debilitating condition.Dumitru Constantin-TeodosiuDespina ConstantinMDPI AGarticleskeletal muscleatrophymuscle functionfatigueBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11587, p 11587 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	skeletal muscle atrophy muscle function fatigue Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	skeletal muscle atrophy muscle function fatigue Biology (General) QH301-705.5 Chemistry QD1-999 Dumitru Constantin-Teodosiu Despina Constantin Molecular Mechanisms of Muscle Fatigue
description	Muscle fatigue (MF) declines the capacity of muscles to complete a task over time at a constant load. MF is usually short-lasting, reversible, and is experienced as a feeling of tiredness or lack of energy. The leading causes of short-lasting fatigue are related to overtraining, undertraining/deconditioning, or physical injury. Conversely, MF can be persistent and more serious when associated with pathological states or following chronic exposure to certain medication or toxic composites. In conjunction with chronic fatigue, the muscle feels floppy, and the force generated by muscles is always low, causing the individual to feel frail constantly. The leading cause underpinning the development of chronic fatigue is related to muscle wasting mediated by aging, immobilization, insulin resistance (through high-fat dietary intake or pharmacologically mediated Peroxisome Proliferator-Activated Receptor (PPAR) agonism), diseases associated with systemic inflammation (arthritis, sepsis, infections, trauma, cardiovascular and respiratory disorders (heart failure, chronic obstructive pulmonary disease (COPD))), chronic kidney failure, muscle dystrophies, muscle myopathies, multiple sclerosis, and, more recently, coronavirus disease 2019 (COVID-19). The primary outcome of displaying chronic muscle fatigue is a poor quality of life. This type of fatigue represents a significant daily challenge for those affected and for the national health authorities through the financial burden attached to patient support. Although the origin of chronic fatigue is multifactorial, the MF in illness conditions is intrinsically linked to the occurrence of muscle loss. The sequence of events leading to chronic fatigue can be schematically denoted as: trigger (genetic or pathological) -> molecular outcome within the muscle cell -> muscle wasting -> loss of muscle function -> occurrence of chronic muscle fatigue. The present review will only highlight and discuss current knowledge on the molecular mechanisms that contribute to the upregulation of muscle wasting, thereby helping us understand how we could prevent or treat this debilitating condition.
format	article
author	Dumitru Constantin-Teodosiu Despina Constantin
author_facet	Dumitru Constantin-Teodosiu Despina Constantin
author_sort	Dumitru Constantin-Teodosiu
title	Molecular Mechanisms of Muscle Fatigue
title_short	Molecular Mechanisms of Muscle Fatigue
title_full	Molecular Mechanisms of Muscle Fatigue
title_fullStr	Molecular Mechanisms of Muscle Fatigue
title_full_unstemmed	Molecular Mechanisms of Muscle Fatigue
title_sort	molecular mechanisms of muscle fatigue
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2cf70f3afb8644a5a7aab84b98cafc39
work_keys_str_mv	AT dumitruconstantinteodosiu molecularmechanismsofmusclefatigue AT despinaconstantin molecularmechanismsofmusclefatigue
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Molecular Mechanisms of Muscle Fatigue

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