Absence of Patient-to-Patient Intrahospital Transmission of <named-content content-type="genus-species">Staphylococcus aureus</named-content> as Determined by Whole-Genome Sequencing

ABSTRACT Nosocomial transmission of pathogens is a major health care challenge. The increasing spread of antibiotic-resistant strains represents an ongoing threat to public health. Previous Staphylococcus aureus transmission studies have focused on transmission of S. aureus between asymptomatic carr...

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Autores principales:	S. Wesley Long, Stephen B. Beres, Randall J. Olsen, James M. Musser
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2014
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/2cf771d7339c4d72beeabf42244a3082
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spelling	oai:doaj.org-article:2cf771d7339c4d72beeabf42244a30822021-11-15T15:45:54ZAbsence of Patient-to-Patient Intrahospital Transmission of <named-content content-type="genus-species">Staphylococcus aureus</named-content> as Determined by Whole-Genome Sequencing10.1128/mBio.01692-142150-7511https://doaj.org/article/2cf771d7339c4d72beeabf42244a30822014-10-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01692-14https://doaj.org/toc/2150-7511ABSTRACT Nosocomial transmission of pathogens is a major health care challenge. The increasing spread of antibiotic-resistant strains represents an ongoing threat to public health. Previous Staphylococcus aureus transmission studies have focused on transmission of S. aureus between asymptomatic carriers or used low-resolution typing methods such as multilocus sequence typing (MLST) or spa typing. To identify patient-to-patient intrahospital transmission using high-resolution genetic analysis, we sequenced the genomes of a consecutive set of 398 S. aureus isolates from sterile-site infections. The S. aureus strains were collected from four hospitals in the Houston Methodist Hospital System over a 6-month period. Importantly, we discovered no evidence of transmission of S. aureus between patients with sterile-site infections. The lack of intrahospital transmission may reflect a fundamental difference between day-to-day transmission events in the hospital setting and the more frequently studied outbreak scenarios. IMPORTANCE Previous studies have suggested that nosocomial transmission of S. aureus is common. Our data revealed an unexpected lack of evidence for intrahospital transmission of S. aureus between patients with invasive infections. This finding has important implications for hospital infection control and public health efforts. In addition, our data demonstrate that highly related pools of S. aureus strains exist in the community which may complicate outbreak investigations.S. Wesley LongStephen B. BeresRandall J. OlsenJames M. MusserAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 5, Iss 5 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 S. Wesley Long Stephen B. Beres Randall J. Olsen James M. Musser Absence of Patient-to-Patient Intrahospital Transmission of <named-content content-type="genus-species">Staphylococcus aureus</named-content> as Determined by Whole-Genome Sequencing
description	ABSTRACT Nosocomial transmission of pathogens is a major health care challenge. The increasing spread of antibiotic-resistant strains represents an ongoing threat to public health. Previous Staphylococcus aureus transmission studies have focused on transmission of S. aureus between asymptomatic carriers or used low-resolution typing methods such as multilocus sequence typing (MLST) or spa typing. To identify patient-to-patient intrahospital transmission using high-resolution genetic analysis, we sequenced the genomes of a consecutive set of 398 S. aureus isolates from sterile-site infections. The S. aureus strains were collected from four hospitals in the Houston Methodist Hospital System over a 6-month period. Importantly, we discovered no evidence of transmission of S. aureus between patients with sterile-site infections. The lack of intrahospital transmission may reflect a fundamental difference between day-to-day transmission events in the hospital setting and the more frequently studied outbreak scenarios. IMPORTANCE Previous studies have suggested that nosocomial transmission of S. aureus is common. Our data revealed an unexpected lack of evidence for intrahospital transmission of S. aureus between patients with invasive infections. This finding has important implications for hospital infection control and public health efforts. In addition, our data demonstrate that highly related pools of S. aureus strains exist in the community which may complicate outbreak investigations.
format	article
author	S. Wesley Long Stephen B. Beres Randall J. Olsen James M. Musser
author_facet	S. Wesley Long Stephen B. Beres Randall J. Olsen James M. Musser
author_sort	S. Wesley Long
title	Absence of Patient-to-Patient Intrahospital Transmission of <named-content content-type="genus-species">Staphylococcus aureus</named-content> as Determined by Whole-Genome Sequencing
title_short	Absence of Patient-to-Patient Intrahospital Transmission of <named-content content-type="genus-species">Staphylococcus aureus</named-content> as Determined by Whole-Genome Sequencing
title_full	Absence of Patient-to-Patient Intrahospital Transmission of <named-content content-type="genus-species">Staphylococcus aureus</named-content> as Determined by Whole-Genome Sequencing
title_fullStr	Absence of Patient-to-Patient Intrahospital Transmission of <named-content content-type="genus-species">Staphylococcus aureus</named-content> as Determined by Whole-Genome Sequencing
title_full_unstemmed	Absence of Patient-to-Patient Intrahospital Transmission of <named-content content-type="genus-species">Staphylococcus aureus</named-content> as Determined by Whole-Genome Sequencing
title_sort	absence of patient-to-patient intrahospital transmission of <named-content content-type="genus-species">staphylococcus aureus</named-content> as determined by whole-genome sequencing
publisher	American Society for Microbiology
publishDate	2014
url	https://doaj.org/article/2cf771d7339c4d72beeabf42244a3082
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Absence of Patient-to-Patient Intrahospital Transmission of <named-content content-type="genus-species">Staphylococcus aureus</named-content> as Determined by Whole-Genome Sequencing

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