Nanotoxicological evaluation of oxidative responses in rat nephrocytes induced by cadmium

Hamdi Trabelsi, Inès Azzouz, Soumaya Ferchichi, Olfa Tebourbi, Mohsen Sakly, Hafedh Abdelmelek Laboratory of Integrative Physiology, Faculty of Sciences of Bizerte, Carthage University, Jarzouna, Tunisia Abstract: The aim of this study was to investigate the interaction of cadmium chlorid...

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Autores principales:	Trabelsi H, Azzouz I, Ferchichi S, Tebourbi O, Sakly M, Abdelmelek H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2cf87babc39f477190415115453c6b6f
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spelling	oai:doaj.org-article:2cf87babc39f477190415115453c6b6f2021-12-02T02:04:22ZNanotoxicological evaluation of oxidative responses in rat nephrocytes induced by cadmium1176-91141178-2013https://doaj.org/article/2cf87babc39f477190415115453c6b6f2013-09-01T00:00:00Zhttp://www.dovepress.com/nanotoxicological-evaluation-of-oxidative-responses-in-rat-nephrocytes-a14278https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Hamdi Trabelsi, Inès Azzouz, Soumaya Ferchichi, Olfa Tebourbi, Mohsen Sakly, Hafedh Abdelmelek Laboratory of Integrative Physiology, Faculty of Sciences of Bizerte, Carthage University, Jarzouna, Tunisia Abstract: The aim of this study was to investigate the interaction of cadmium chloride with mineral elements in rat nephrocytes in terms of the biosynthesis of nanocomplexes. The results show that selenium supplementation enhanced cadmium accumulation in kidneys. Analysis of the fluorescence revealed an increase in red fluorescence in the kidneys of rats co-exposed to cadmium and selenium. Interestingly, X-ray diffraction measurements carried out on kidney fractions of co-exposed rats point to the biosynthesis of cadmium selenide and/or sulfide nanoparticles (about 62 nm in size). Oxidative stress assays showed the ability of selenium to reduce lipid peroxidation and to restore glutathione peroxidase and superoxide dismutase activity in kidneys. Hence, cadmium complexation with selenium and sulfur at a nanoscale level could reduce oxidative stress induced by cadmium in kidneys. Keywords: nanoparticles, detoxification, oxidative stress, X-ray diffraction, fluorescence microscopy, kidneysTrabelsi HAzzouz IFerchichi STebourbi OSakly MAbdelmelek HDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss default, Pp 3447-3453 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Trabelsi H Azzouz I Ferchichi S Tebourbi O Sakly M Abdelmelek H Nanotoxicological evaluation of oxidative responses in rat nephrocytes induced by cadmium
description	Hamdi Trabelsi, Inès Azzouz, Soumaya Ferchichi, Olfa Tebourbi, Mohsen Sakly, Hafedh Abdelmelek Laboratory of Integrative Physiology, Faculty of Sciences of Bizerte, Carthage University, Jarzouna, Tunisia Abstract: The aim of this study was to investigate the interaction of cadmium chloride with mineral elements in rat nephrocytes in terms of the biosynthesis of nanocomplexes. The results show that selenium supplementation enhanced cadmium accumulation in kidneys. Analysis of the fluorescence revealed an increase in red fluorescence in the kidneys of rats co-exposed to cadmium and selenium. Interestingly, X-ray diffraction measurements carried out on kidney fractions of co-exposed rats point to the biosynthesis of cadmium selenide and/or sulfide nanoparticles (about 62 nm in size). Oxidative stress assays showed the ability of selenium to reduce lipid peroxidation and to restore glutathione peroxidase and superoxide dismutase activity in kidneys. Hence, cadmium complexation with selenium and sulfur at a nanoscale level could reduce oxidative stress induced by cadmium in kidneys. Keywords: nanoparticles, detoxification, oxidative stress, X-ray diffraction, fluorescence microscopy, kidneys
format	article
author	Trabelsi H Azzouz I Ferchichi S Tebourbi O Sakly M Abdelmelek H
author_facet	Trabelsi H Azzouz I Ferchichi S Tebourbi O Sakly M Abdelmelek H
author_sort	Trabelsi H
title	Nanotoxicological evaluation of oxidative responses in rat nephrocytes induced by cadmium
title_short	Nanotoxicological evaluation of oxidative responses in rat nephrocytes induced by cadmium
title_full	Nanotoxicological evaluation of oxidative responses in rat nephrocytes induced by cadmium
title_fullStr	Nanotoxicological evaluation of oxidative responses in rat nephrocytes induced by cadmium
title_full_unstemmed	Nanotoxicological evaluation of oxidative responses in rat nephrocytes induced by cadmium
title_sort	nanotoxicological evaluation of oxidative responses in rat nephrocytes induced by cadmium
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/2cf87babc39f477190415115453c6b6f
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Nanotoxicological evaluation of oxidative responses in rat nephrocytes induced by cadmium

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