Chronic opioid use modulates human enteric microbiota and intestinal barrier integrity

Over the past three decades the United States has experienced a devastating opioid epidemic. One of the many debilitating side effects of chronic opioid use is opioid-induced bowel dysfunction. We investigated the impact of methadone maintenance treatment (MMT) on the gut microbiome, the gut bacteri...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Angélica Cruz-Lebrón, Ramona Johnson, Claire Mazahery, Zach Troyer, Samira Joussef-Piña, Miguel E. Quiñones-Mateu, Christopher M Strauch, Stanley L. Hazen, Alan D. Levine
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	intestinal permeability tight junctions akkermansia muciniphila short-chain fatty acids metabolomics methadone Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/2cfa106a74bf42a6a680b1086752c4b3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2cfa106a74bf42a6a680b1086752c4b3
record_format	dspace
spelling	oai:doaj.org-article:2cfa106a74bf42a6a680b1086752c4b32021-11-26T11:19:48ZChronic opioid use modulates human enteric microbiota and intestinal barrier integrity1949-09761949-098410.1080/19490976.2021.1946368https://doaj.org/article/2cfa106a74bf42a6a680b1086752c4b32021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/19490976.2021.1946368https://doaj.org/toc/1949-0976https://doaj.org/toc/1949-0984Over the past three decades the United States has experienced a devastating opioid epidemic. One of the many debilitating side effects of chronic opioid use is opioid-induced bowel dysfunction. We investigated the impact of methadone maintenance treatment (MMT) on the gut microbiome, the gut bacterial metabolite profile, and intestinal barrier integrity. An imbalance in key bacterial communities required for production of short-chain fatty acids (SCFAs), mucus degradation, and maintenance of barrier integrity was identified. Consistent with dysbiosis, levels of fecal SCFAs were reduced in MMT. We demonstrated that metabolites synthesized by Akkermansia muciniphila modulate intestinal barrier integrity in vitro by strengthening the pore pathway and regulating tight junction protein expression. This study provides essential information about the therapeutic potential of A. muciniphila and warrants development of new clinical strategies that aim to normalize the gut microbiome in individuals affected by chronic opioid use.Angélica Cruz-LebrónRamona JohnsonClaire MazaheryZach TroyerSamira Joussef-PiñaMiguel E. Quiñones-MateuChristopher M StrauchStanley L. HazenAlan D. LevineTaylor & Francis Grouparticleintestinal permeabilitytight junctionsakkermansia muciniphilashort-chain fatty acidsmetabolomicsmethadoneDiseases of the digestive system. GastroenterologyRC799-869ENGut Microbes, Vol 13, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	intestinal permeability tight junctions akkermansia muciniphila short-chain fatty acids metabolomics methadone Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	intestinal permeability tight junctions akkermansia muciniphila short-chain fatty acids metabolomics methadone Diseases of the digestive system. Gastroenterology RC799-869 Angélica Cruz-Lebrón Ramona Johnson Claire Mazahery Zach Troyer Samira Joussef-Piña Miguel E. Quiñones-Mateu Christopher M Strauch Stanley L. Hazen Alan D. Levine Chronic opioid use modulates human enteric microbiota and intestinal barrier integrity
description	Over the past three decades the United States has experienced a devastating opioid epidemic. One of the many debilitating side effects of chronic opioid use is opioid-induced bowel dysfunction. We investigated the impact of methadone maintenance treatment (MMT) on the gut microbiome, the gut bacterial metabolite profile, and intestinal barrier integrity. An imbalance in key bacterial communities required for production of short-chain fatty acids (SCFAs), mucus degradation, and maintenance of barrier integrity was identified. Consistent with dysbiosis, levels of fecal SCFAs were reduced in MMT. We demonstrated that metabolites synthesized by Akkermansia muciniphila modulate intestinal barrier integrity in vitro by strengthening the pore pathway and regulating tight junction protein expression. This study provides essential information about the therapeutic potential of A. muciniphila and warrants development of new clinical strategies that aim to normalize the gut microbiome in individuals affected by chronic opioid use.
format	article
author	Angélica Cruz-Lebrón Ramona Johnson Claire Mazahery Zach Troyer Samira Joussef-Piña Miguel E. Quiñones-Mateu Christopher M Strauch Stanley L. Hazen Alan D. Levine
author_facet	Angélica Cruz-Lebrón Ramona Johnson Claire Mazahery Zach Troyer Samira Joussef-Piña Miguel E. Quiñones-Mateu Christopher M Strauch Stanley L. Hazen Alan D. Levine
author_sort	Angélica Cruz-Lebrón
title	Chronic opioid use modulates human enteric microbiota and intestinal barrier integrity
title_short	Chronic opioid use modulates human enteric microbiota and intestinal barrier integrity
title_full	Chronic opioid use modulates human enteric microbiota and intestinal barrier integrity
title_fullStr	Chronic opioid use modulates human enteric microbiota and intestinal barrier integrity
title_full_unstemmed	Chronic opioid use modulates human enteric microbiota and intestinal barrier integrity
title_sort	chronic opioid use modulates human enteric microbiota and intestinal barrier integrity
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/2cfa106a74bf42a6a680b1086752c4b3
work_keys_str_mv	AT angelicacruzlebron chronicopioidusemodulateshumanentericmicrobiotaandintestinalbarrierintegrity AT ramonajohnson chronicopioidusemodulateshumanentericmicrobiotaandintestinalbarrierintegrity AT clairemazahery chronicopioidusemodulateshumanentericmicrobiotaandintestinalbarrierintegrity AT zachtroyer chronicopioidusemodulateshumanentericmicrobiotaandintestinalbarrierintegrity AT samirajoussefpina chronicopioidusemodulateshumanentericmicrobiotaandintestinalbarrierintegrity AT miguelequinonesmateu chronicopioidusemodulateshumanentericmicrobiotaandintestinalbarrierintegrity AT christophermstrauch chronicopioidusemodulateshumanentericmicrobiotaandintestinalbarrierintegrity AT stanleylhazen chronicopioidusemodulateshumanentericmicrobiotaandintestinalbarrierintegrity AT alandlevine chronicopioidusemodulateshumanentericmicrobiotaandintestinalbarrierintegrity
_version_	1718409457113759744

Chronic opioid use modulates human enteric microbiota and intestinal barrier integrity

Ejemplares similares