The Role of Genetic Pathways in the Development of Chemoradiation Resistance in Nasopharyngeal Carcinoma (NPC) Patients

Management of nasopharyngeal carcinoma (NPC) remains elusive despite new developments and advancement that has been made in the current management approaches. A patient’s survival and prognosis remain dismal especially for a late-stage disease. This is highly attribute to the chemoradiation resistan...

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Autores principales:	Norhafiza Mat Lazim, Che Ismail Che Lah, Wan Khairunnisa Wan Juhari, Sarina Sulong, Bin Alwi Zilfalil, Baharudin Abdullah
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	nasopharyngeal carcinoma chemoresistance cancer stem cells genetic alteration fusion genes locoregional recurrence Genetics QH426-470
Acceso en línea:	https://doaj.org/article/2cfc5054349546cab6774ea5db34fe5d
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spelling	oai:doaj.org-article:2cfc5054349546cab6774ea5db34fe5d2021-11-25T17:42:32ZThe Role of Genetic Pathways in the Development of Chemoradiation Resistance in Nasopharyngeal Carcinoma (NPC) Patients10.3390/genes121118352073-4425https://doaj.org/article/2cfc5054349546cab6774ea5db34fe5d2021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4425/12/11/1835https://doaj.org/toc/2073-4425Management of nasopharyngeal carcinoma (NPC) remains elusive despite new developments and advancement that has been made in the current management approaches. A patient’s survival and prognosis remain dismal especially for a late-stage disease. This is highly attribute to the chemoradiation resistance. Arrays of genes and molecular mechanisms underlie the development of chemoradiation resistance in NPC. Imperatively, unravelling the true pathogenesis of chemoradiation resistance is crucial as these significant proteins and genes can be modulated to produce an effective therapeutic target. It is pivotal to identify the chemoradiation resistance at the very beginning in order to combat the chemoradiation resistance efficiently. Intense research in the genetic ecosphere is critical, as the discovery and development of novel therapeutic targets can be used for screening, diagnosis, and treating the chemoradiation resistance aggressively. This will escalate the management trajectory of NPC patients. This article highlights the significance of genetic and molecular factors that play critical roles in the chemoradiation resistance and how these factors may be modified for next-generation targeted therapy products.Norhafiza Mat LazimChe Ismail Che LahWan Khairunnisa Wan JuhariSarina SulongBin Alwi ZilfalilBaharudin AbdullahMDPI AGarticlenasopharyngeal carcinomachemoresistancecancer stem cellsgenetic alterationfusion geneslocoregional recurrenceGeneticsQH426-470ENGenes, Vol 12, Iss 1835, p 1835 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	nasopharyngeal carcinoma chemoresistance cancer stem cells genetic alteration fusion genes locoregional recurrence Genetics QH426-470
spellingShingle	nasopharyngeal carcinoma chemoresistance cancer stem cells genetic alteration fusion genes locoregional recurrence Genetics QH426-470 Norhafiza Mat Lazim Che Ismail Che Lah Wan Khairunnisa Wan Juhari Sarina Sulong Bin Alwi Zilfalil Baharudin Abdullah The Role of Genetic Pathways in the Development of Chemoradiation Resistance in Nasopharyngeal Carcinoma (NPC) Patients
description	Management of nasopharyngeal carcinoma (NPC) remains elusive despite new developments and advancement that has been made in the current management approaches. A patient’s survival and prognosis remain dismal especially for a late-stage disease. This is highly attribute to the chemoradiation resistance. Arrays of genes and molecular mechanisms underlie the development of chemoradiation resistance in NPC. Imperatively, unravelling the true pathogenesis of chemoradiation resistance is crucial as these significant proteins and genes can be modulated to produce an effective therapeutic target. It is pivotal to identify the chemoradiation resistance at the very beginning in order to combat the chemoradiation resistance efficiently. Intense research in the genetic ecosphere is critical, as the discovery and development of novel therapeutic targets can be used for screening, diagnosis, and treating the chemoradiation resistance aggressively. This will escalate the management trajectory of NPC patients. This article highlights the significance of genetic and molecular factors that play critical roles in the chemoradiation resistance and how these factors may be modified for next-generation targeted therapy products.
format	article
author	Norhafiza Mat Lazim Che Ismail Che Lah Wan Khairunnisa Wan Juhari Sarina Sulong Bin Alwi Zilfalil Baharudin Abdullah
author_facet	Norhafiza Mat Lazim Che Ismail Che Lah Wan Khairunnisa Wan Juhari Sarina Sulong Bin Alwi Zilfalil Baharudin Abdullah
author_sort	Norhafiza Mat Lazim
title	The Role of Genetic Pathways in the Development of Chemoradiation Resistance in Nasopharyngeal Carcinoma (NPC) Patients
title_short	The Role of Genetic Pathways in the Development of Chemoradiation Resistance in Nasopharyngeal Carcinoma (NPC) Patients
title_full	The Role of Genetic Pathways in the Development of Chemoradiation Resistance in Nasopharyngeal Carcinoma (NPC) Patients
title_fullStr	The Role of Genetic Pathways in the Development of Chemoradiation Resistance in Nasopharyngeal Carcinoma (NPC) Patients
title_full_unstemmed	The Role of Genetic Pathways in the Development of Chemoradiation Resistance in Nasopharyngeal Carcinoma (NPC) Patients
title_sort	role of genetic pathways in the development of chemoradiation resistance in nasopharyngeal carcinoma (npc) patients
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2cfc5054349546cab6774ea5db34fe5d
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The Role of Genetic Pathways in the Development of Chemoradiation Resistance in Nasopharyngeal Carcinoma (NPC) Patients

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