Beneficial and anti-inflammatory effects of formulated prebiotics, probiotics, and synbiotics in normal and acute colitis mice

In inflammatory bowel disease (IBD), an altered gut microbiota is observed and is a proposed causal factor for compromised intestinal integrity and disease progression. Therefore, maintenance and modulation of the gut microbiome may be beneficial to health and for treatment of IBD. Prebiotics, probi...

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Autores principales:	Wing-Yan Wong, Brandon Dow Chan, Tsz-Wing Leung, ManXin Chen, William Chi-Shing Tai
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Prebiotics Probiotics Synbiotics Gut microbiota Tight junction Inflammatory bowel disease Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/2cfc866174d14db284b963a3a2ff7e58
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spelling	oai:doaj.org-article:2cfc866174d14db284b963a3a2ff7e582021-12-02T05:00:16ZBeneficial and anti-inflammatory effects of formulated prebiotics, probiotics, and synbiotics in normal and acute colitis mice1756-464610.1016/j.jff.2021.104871https://doaj.org/article/2cfc866174d14db284b963a3a2ff7e582022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S175646462100520Xhttps://doaj.org/toc/1756-4646In inflammatory bowel disease (IBD), an altered gut microbiota is observed and is a proposed causal factor for compromised intestinal integrity and disease progression. Therefore, maintenance and modulation of the gut microbiome may be beneficial to health and for treatment of IBD. Prebiotics, probiotics, and synbiotics have been suggested to positively impact the gut microbiota and thus we aimed to evaluate the effects of a formulated prebiotic mixture (Pre), probiotic mixture (Pro), and synbiotics (Syn) in normal mice, and their therapeutic effects in acute dextran sulfate sodium (DSS)-induced mice. We observed significant reductions in plasma IL-6 levels and increased intestinal occludin expression in both models after treatment. In DSS-induced mice, treatment modulated gut microbiota, improved gut integrity, upregulated anti-inflammatory cytokines, and suppressed plasma pro-inflammatory mediators, potentially via inhibition of IL-6/STAT3 signaling. Our results demonstrate the beneficial effects of Pre, Pro, and Syn consumption and their potential therapeutic effects in IBD.Wing-Yan WongBrandon Dow ChanTsz-Wing LeungManXin ChenWilliam Chi-Shing TaiElsevierarticlePrebioticsProbioticsSynbioticsGut microbiotaTight junctionInflammatory bowel diseaseNutrition. Foods and food supplyTX341-641ENJournal of Functional Foods, Vol 88, Iss , Pp 104871- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Prebiotics Probiotics Synbiotics Gut microbiota Tight junction Inflammatory bowel disease Nutrition. Foods and food supply TX341-641
spellingShingle	Prebiotics Probiotics Synbiotics Gut microbiota Tight junction Inflammatory bowel disease Nutrition. Foods and food supply TX341-641 Wing-Yan Wong Brandon Dow Chan Tsz-Wing Leung ManXin Chen William Chi-Shing Tai Beneficial and anti-inflammatory effects of formulated prebiotics, probiotics, and synbiotics in normal and acute colitis mice
description	In inflammatory bowel disease (IBD), an altered gut microbiota is observed and is a proposed causal factor for compromised intestinal integrity and disease progression. Therefore, maintenance and modulation of the gut microbiome may be beneficial to health and for treatment of IBD. Prebiotics, probiotics, and synbiotics have been suggested to positively impact the gut microbiota and thus we aimed to evaluate the effects of a formulated prebiotic mixture (Pre), probiotic mixture (Pro), and synbiotics (Syn) in normal mice, and their therapeutic effects in acute dextran sulfate sodium (DSS)-induced mice. We observed significant reductions in plasma IL-6 levels and increased intestinal occludin expression in both models after treatment. In DSS-induced mice, treatment modulated gut microbiota, improved gut integrity, upregulated anti-inflammatory cytokines, and suppressed plasma pro-inflammatory mediators, potentially via inhibition of IL-6/STAT3 signaling. Our results demonstrate the beneficial effects of Pre, Pro, and Syn consumption and their potential therapeutic effects in IBD.
format	article
author	Wing-Yan Wong Brandon Dow Chan Tsz-Wing Leung ManXin Chen William Chi-Shing Tai
author_facet	Wing-Yan Wong Brandon Dow Chan Tsz-Wing Leung ManXin Chen William Chi-Shing Tai
author_sort	Wing-Yan Wong
title	Beneficial and anti-inflammatory effects of formulated prebiotics, probiotics, and synbiotics in normal and acute colitis mice
title_short	Beneficial and anti-inflammatory effects of formulated prebiotics, probiotics, and synbiotics in normal and acute colitis mice
title_full	Beneficial and anti-inflammatory effects of formulated prebiotics, probiotics, and synbiotics in normal and acute colitis mice
title_fullStr	Beneficial and anti-inflammatory effects of formulated prebiotics, probiotics, and synbiotics in normal and acute colitis mice
title_full_unstemmed	Beneficial and anti-inflammatory effects of formulated prebiotics, probiotics, and synbiotics in normal and acute colitis mice
title_sort	beneficial and anti-inflammatory effects of formulated prebiotics, probiotics, and synbiotics in normal and acute colitis mice
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/2cfc866174d14db284b963a3a2ff7e58
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Beneficial and anti-inflammatory effects of formulated prebiotics, probiotics, and synbiotics in normal and acute colitis mice

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