Association of polymorphisms the trigger receptor gene expressed by myeloid cells (<i>TREM-1</i>) in sporadic congenital heart defects without chromosome anomalies

Eight polymorphic loci in the TREM-1 gene (rs1817537, rs3804277, rs6910730, rs7768162, rs2234246, rs4711668, rs9471535 and rs2234237) were genotyped in 131 children with congenital heart defects (CHD) without proven chromosomal anomalies, and 103 conditionally healthy children (control group) matche...

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Autores principales:	A. V. Shabaldin, A. V. Tsepokina, S. A. Shmulevich, N. S. Deeva, A. V. Ponasenko, L. V. Antonova, E. V. Shabaldina
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2020
Materias:	trem-1 congenital heart defects genetic polymorphism inter-locus interactions Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/2d01fd644e024a168193648d6c287b7d
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spelling	oai:doaj.org-article:2d01fd644e024a168193648d6c287b7d2021-11-18T08:03:49ZAssociation of polymorphisms the trigger receptor gene expressed by myeloid cells (<i>TREM-1</i>) in sporadic congenital heart defects without chromosome anomalies1563-06252313-741X10.15789/1563-0625-AOP-1948https://doaj.org/article/2d01fd644e024a168193648d6c287b7d2020-05-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1948https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XEight polymorphic loci in the TREM-1 gene (rs1817537, rs3804277, rs6910730, rs7768162, rs2234246, rs4711668, rs9471535 and rs2234237) were genotyped in 131 children with congenital heart defects (CHD) without proven chromosomal anomalies, and 103 conditionally healthy children (control group) matched for age and gender. Genotyping was performed by polymerase chain reaction (PCR) using TaqMan probes. The frequency of these genotypes was checked for Hardy–Weinberg equilibrium using a free tool (http://bioinfo.iconcologia.net/SNPstats). Analysis of inter-locus interactions was performed by Multifactor Dimensionality Reduction method. It was shown that the combination of four loci, i.e., rs1817537, rs3804277, rs2234246 and rs7768162 may determine susceptibility and persistence for CHD without chromosomal diseases. Increased CHD risk is associated with two-locus model rs1817537G/G – rs3804277T/T (OR = 8.26) and three-locus model rs2234246C/T – rs1817537C/G – rs7768162A/G (OR = 13.76). The two-locus model rs1817537С/С – rs3804277T/T (OR = 0.03) and three-locus model rs2234246T/T – rs1817537C/C – rs7768162G/G (OR = 0.03) were associated with a decreased risk for CHD without detectable chromosomal anomalies.A. V. ShabaldinA. V. TsepokinaS. A. ShmulevichN. S. DeevaA. V. PonasenkoL. V. AntonovaE. V. ShabaldinaSPb RAACIarticletrem-1congenital heart defectsgenetic polymorphisminter-locus interactionsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 22, Iss 3, Pp 505-518 (2020)
institution	DOAJ
collection	DOAJ
language	RU
topic	trem-1 congenital heart defects genetic polymorphism inter-locus interactions Immunologic diseases. Allergy RC581-607
spellingShingle	trem-1 congenital heart defects genetic polymorphism inter-locus interactions Immunologic diseases. Allergy RC581-607 A. V. Shabaldin A. V. Tsepokina S. A. Shmulevich N. S. Deeva A. V. Ponasenko L. V. Antonova E. V. Shabaldina Association of polymorphisms the trigger receptor gene expressed by myeloid cells (<i>TREM-1</i>) in sporadic congenital heart defects without chromosome anomalies
description	Eight polymorphic loci in the TREM-1 gene (rs1817537, rs3804277, rs6910730, rs7768162, rs2234246, rs4711668, rs9471535 and rs2234237) were genotyped in 131 children with congenital heart defects (CHD) without proven chromosomal anomalies, and 103 conditionally healthy children (control group) matched for age and gender. Genotyping was performed by polymerase chain reaction (PCR) using TaqMan probes. The frequency of these genotypes was checked for Hardy–Weinberg equilibrium using a free tool (http://bioinfo.iconcologia.net/SNPstats). Analysis of inter-locus interactions was performed by Multifactor Dimensionality Reduction method. It was shown that the combination of four loci, i.e., rs1817537, rs3804277, rs2234246 and rs7768162 may determine susceptibility and persistence for CHD without chromosomal diseases. Increased CHD risk is associated with two-locus model rs1817537G/G – rs3804277T/T (OR = 8.26) and three-locus model rs2234246C/T – rs1817537C/G – rs7768162A/G (OR = 13.76). The two-locus model rs1817537С/С – rs3804277T/T (OR = 0.03) and three-locus model rs2234246T/T – rs1817537C/C – rs7768162G/G (OR = 0.03) were associated with a decreased risk for CHD without detectable chromosomal anomalies.
format	article
author	A. V. Shabaldin A. V. Tsepokina S. A. Shmulevich N. S. Deeva A. V. Ponasenko L. V. Antonova E. V. Shabaldina
author_facet	A. V. Shabaldin A. V. Tsepokina S. A. Shmulevich N. S. Deeva A. V. Ponasenko L. V. Antonova E. V. Shabaldina
author_sort	A. V. Shabaldin
title	Association of polymorphisms the trigger receptor gene expressed by myeloid cells (<i>TREM-1</i>) in sporadic congenital heart defects without chromosome anomalies
title_short	Association of polymorphisms the trigger receptor gene expressed by myeloid cells (<i>TREM-1</i>) in sporadic congenital heart defects without chromosome anomalies
title_full	Association of polymorphisms the trigger receptor gene expressed by myeloid cells (<i>TREM-1</i>) in sporadic congenital heart defects without chromosome anomalies
title_fullStr	Association of polymorphisms the trigger receptor gene expressed by myeloid cells (<i>TREM-1</i>) in sporadic congenital heart defects without chromosome anomalies
title_full_unstemmed	Association of polymorphisms the trigger receptor gene expressed by myeloid cells (<i>TREM-1</i>) in sporadic congenital heart defects without chromosome anomalies
title_sort	association of polymorphisms the trigger receptor gene expressed by myeloid cells (<i>trem-1</i>) in sporadic congenital heart defects without chromosome anomalies
publisher	SPb RAACI
publishDate	2020
url	https://doaj.org/article/2d01fd644e024a168193648d6c287b7d
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Association of polymorphisms the trigger receptor gene expressed by myeloid cells (<i>TREM-1</i>) in sporadic congenital heart defects without chromosome anomalies

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