A guanine-flipping and sequestration mechanism for G-quadruplex unwinding by RecQ helicases

How G-quadruplexes (G4s) are resolved by helicases is still a matter of investigation. Here the authors provide mechanistic insight into G4s unwinding by presenting a crystal structure of resolved G4 DNA and the G4 binding domain of RecQ helicase from the bacterium Cronobacter sakazakii.

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Autores principales:	Andrew F. Voter, Yupeng Qiu, Ramreddy Tippana, Sua Myong, James L. Keck
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2d0ad37a45eb4231a16e4299162f5d0e
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spelling	oai:doaj.org-article:2d0ad37a45eb4231a16e4299162f5d0e2021-12-02T15:33:44ZA guanine-flipping and sequestration mechanism for G-quadruplex unwinding by RecQ helicases10.1038/s41467-018-06751-82041-1723https://doaj.org/article/2d0ad37a45eb4231a16e4299162f5d0e2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06751-8https://doaj.org/toc/2041-1723How G-quadruplexes (G4s) are resolved by helicases is still a matter of investigation. Here the authors provide mechanistic insight into G4s unwinding by presenting a crystal structure of resolved G4 DNA and the G4 binding domain of RecQ helicase from the bacterium Cronobacter sakazakii.Andrew F. VoterYupeng QiuRamreddy TippanaSua MyongJames L. KeckNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Andrew F. Voter Yupeng Qiu Ramreddy Tippana Sua Myong James L. Keck A guanine-flipping and sequestration mechanism for G-quadruplex unwinding by RecQ helicases
description	How G-quadruplexes (G4s) are resolved by helicases is still a matter of investigation. Here the authors provide mechanistic insight into G4s unwinding by presenting a crystal structure of resolved G4 DNA and the G4 binding domain of RecQ helicase from the bacterium Cronobacter sakazakii.
format	article
author	Andrew F. Voter Yupeng Qiu Ramreddy Tippana Sua Myong James L. Keck
author_facet	Andrew F. Voter Yupeng Qiu Ramreddy Tippana Sua Myong James L. Keck
author_sort	Andrew F. Voter
title	A guanine-flipping and sequestration mechanism for G-quadruplex unwinding by RecQ helicases
title_short	A guanine-flipping and sequestration mechanism for G-quadruplex unwinding by RecQ helicases
title_full	A guanine-flipping and sequestration mechanism for G-quadruplex unwinding by RecQ helicases
title_fullStr	A guanine-flipping and sequestration mechanism for G-quadruplex unwinding by RecQ helicases
title_full_unstemmed	A guanine-flipping and sequestration mechanism for G-quadruplex unwinding by RecQ helicases
title_sort	guanine-flipping and sequestration mechanism for g-quadruplex unwinding by recq helicases
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2d0ad37a45eb4231a16e4299162f5d0e
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A guanine-flipping and sequestration mechanism for G-quadruplex unwinding by RecQ helicases

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