Maternal HtrA3 optimizes placental development to influence offspring birth weight and subsequent white fat gain in adulthood

Abstract High temperature requirement factor A3 (HtrA3), a member of the HtrA protease family, is highly expressed in the developing placenta, including the maternal decidual cells in both mice and humans. In this study we deleted the HtrA3 gene in the mouse and crossed females carrying zero, one, o...

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Autores principales:	Ying Li, Lois A. Salamonsen, Jonathan Hyett, Fabricio da Silva Costa, Guiying Nie
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2d0d394657c5485fa77aa96a33501d1e
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spelling	oai:doaj.org-article:2d0d394657c5485fa77aa96a33501d1e2021-12-02T12:30:34ZMaternal HtrA3 optimizes placental development to influence offspring birth weight and subsequent white fat gain in adulthood10.1038/s41598-017-04867-32045-2322https://doaj.org/article/2d0d394657c5485fa77aa96a33501d1e2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04867-3https://doaj.org/toc/2045-2322Abstract High temperature requirement factor A3 (HtrA3), a member of the HtrA protease family, is highly expressed in the developing placenta, including the maternal decidual cells in both mice and humans. In this study we deleted the HtrA3 gene in the mouse and crossed females carrying zero, one, or two HtrA3-expressing alleles with HtrA3+/− males to investigate the role of maternal vs fetal HtrA3 in placentation. Although HtrA3−/− mice were phenotypically normal and fertile, HtrA3 deletion in the mother resulted in intra-uterine growth restriction (IUGR). Disorganization of labyrinthine fetal capillaries was the major placental defect when HtrA3 was absent. The IUGR caused by maternal HtrA3 deletion, albeit being mild, significantly altered offspring growth trajectory long after birth. By 8 months of age, mice born to HtrA3-deficient mothers, independent of their own genotype, were significantly heavier and contained a larger mass of white fat. We further demonstrated that in women serum levels of HtrA3 during early pregnancy were significantly lower in IUGR pregnancies, establishing an association between lower HtrA3 levels and placental insufficiency in the human. This study thus revealed the importance of maternal HtrA3 in optimizing placental development and its long-term impact on the offspring well beyond in utero growth.Ying LiLois A. SalamonsenJonathan HyettFabricio da Silva CostaGuiying NieNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ying Li Lois A. Salamonsen Jonathan Hyett Fabricio da Silva Costa Guiying Nie Maternal HtrA3 optimizes placental development to influence offspring birth weight and subsequent white fat gain in adulthood
description	Abstract High temperature requirement factor A3 (HtrA3), a member of the HtrA protease family, is highly expressed in the developing placenta, including the maternal decidual cells in both mice and humans. In this study we deleted the HtrA3 gene in the mouse and crossed females carrying zero, one, or two HtrA3-expressing alleles with HtrA3+/− males to investigate the role of maternal vs fetal HtrA3 in placentation. Although HtrA3−/− mice were phenotypically normal and fertile, HtrA3 deletion in the mother resulted in intra-uterine growth restriction (IUGR). Disorganization of labyrinthine fetal capillaries was the major placental defect when HtrA3 was absent. The IUGR caused by maternal HtrA3 deletion, albeit being mild, significantly altered offspring growth trajectory long after birth. By 8 months of age, mice born to HtrA3-deficient mothers, independent of their own genotype, were significantly heavier and contained a larger mass of white fat. We further demonstrated that in women serum levels of HtrA3 during early pregnancy were significantly lower in IUGR pregnancies, establishing an association between lower HtrA3 levels and placental insufficiency in the human. This study thus revealed the importance of maternal HtrA3 in optimizing placental development and its long-term impact on the offspring well beyond in utero growth.
format	article
author	Ying Li Lois A. Salamonsen Jonathan Hyett Fabricio da Silva Costa Guiying Nie
author_facet	Ying Li Lois A. Salamonsen Jonathan Hyett Fabricio da Silva Costa Guiying Nie
author_sort	Ying Li
title	Maternal HtrA3 optimizes placental development to influence offspring birth weight and subsequent white fat gain in adulthood
title_short	Maternal HtrA3 optimizes placental development to influence offspring birth weight and subsequent white fat gain in adulthood
title_full	Maternal HtrA3 optimizes placental development to influence offspring birth weight and subsequent white fat gain in adulthood
title_fullStr	Maternal HtrA3 optimizes placental development to influence offspring birth weight and subsequent white fat gain in adulthood
title_full_unstemmed	Maternal HtrA3 optimizes placental development to influence offspring birth weight and subsequent white fat gain in adulthood
title_sort	maternal htra3 optimizes placental development to influence offspring birth weight and subsequent white fat gain in adulthood
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2d0d394657c5485fa77aa96a33501d1e
work_keys_str_mv	AT yingli maternalhtra3optimizesplacentaldevelopmenttoinfluenceoffspringbirthweightandsubsequentwhitefatgaininadulthood AT loisasalamonsen maternalhtra3optimizesplacentaldevelopmenttoinfluenceoffspringbirthweightandsubsequentwhitefatgaininadulthood AT jonathanhyett maternalhtra3optimizesplacentaldevelopmenttoinfluenceoffspringbirthweightandsubsequentwhitefatgaininadulthood AT fabriciodasilvacosta maternalhtra3optimizesplacentaldevelopmenttoinfluenceoffspringbirthweightandsubsequentwhitefatgaininadulthood AT guiyingnie maternalhtra3optimizesplacentaldevelopmenttoinfluenceoffspringbirthweightandsubsequentwhitefatgaininadulthood
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Maternal HtrA3 optimizes placental development to influence offspring birth weight and subsequent white fat gain in adulthood

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