The transcription-repair coupling factor Mfd associates with RNA polymerase in the absence of exogenous damage

The bacterial transcription-repair coupling factor Mfd displaces stalled RNA polymerase (RNAP) by promoting transcription termination at sites of DNA lesions. Here the authors find—using single molecule imaging in live Escherichia coli—that RNAP stalls frequently during transcription, and needs to b...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Han N. Ho, Antoine M. van Oijen, Harshad Ghodke
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2d10619a53944cc582941dbf097af73c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2d10619a53944cc582941dbf097af73c
record_format	dspace
spelling	oai:doaj.org-article:2d10619a53944cc582941dbf097af73c2021-12-02T17:31:15ZThe transcription-repair coupling factor Mfd associates with RNA polymerase in the absence of exogenous damage10.1038/s41467-018-03790-z2041-1723https://doaj.org/article/2d10619a53944cc582941dbf097af73c2018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03790-zhttps://doaj.org/toc/2041-1723The bacterial transcription-repair coupling factor Mfd displaces stalled RNA polymerase (RNAP) by promoting transcription termination at sites of DNA lesions. Here the authors find—using single molecule imaging in live Escherichia coli—that RNAP stalls frequently during transcription, and needs to be rescued by Mfd during normal growth.Han N. HoAntoine M. van OijenHarshad GhodkeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Han N. Ho Antoine M. van Oijen Harshad Ghodke The transcription-repair coupling factor Mfd associates with RNA polymerase in the absence of exogenous damage
description	The bacterial transcription-repair coupling factor Mfd displaces stalled RNA polymerase (RNAP) by promoting transcription termination at sites of DNA lesions. Here the authors find—using single molecule imaging in live Escherichia coli—that RNAP stalls frequently during transcription, and needs to be rescued by Mfd during normal growth.
format	article
author	Han N. Ho Antoine M. van Oijen Harshad Ghodke
author_facet	Han N. Ho Antoine M. van Oijen Harshad Ghodke
author_sort	Han N. Ho
title	The transcription-repair coupling factor Mfd associates with RNA polymerase in the absence of exogenous damage
title_short	The transcription-repair coupling factor Mfd associates with RNA polymerase in the absence of exogenous damage
title_full	The transcription-repair coupling factor Mfd associates with RNA polymerase in the absence of exogenous damage
title_fullStr	The transcription-repair coupling factor Mfd associates with RNA polymerase in the absence of exogenous damage
title_full_unstemmed	The transcription-repair coupling factor Mfd associates with RNA polymerase in the absence of exogenous damage
title_sort	transcription-repair coupling factor mfd associates with rna polymerase in the absence of exogenous damage
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2d10619a53944cc582941dbf097af73c
work_keys_str_mv	AT hannho thetranscriptionrepaircouplingfactormfdassociateswithrnapolymeraseintheabsenceofexogenousdamage AT antoinemvanoijen thetranscriptionrepaircouplingfactormfdassociateswithrnapolymeraseintheabsenceofexogenousdamage AT harshadghodke thetranscriptionrepaircouplingfactormfdassociateswithrnapolymeraseintheabsenceofexogenousdamage AT hannho transcriptionrepaircouplingfactormfdassociateswithrnapolymeraseintheabsenceofexogenousdamage AT antoinemvanoijen transcriptionrepaircouplingfactormfdassociateswithrnapolymeraseintheabsenceofexogenousdamage AT harshadghodke transcriptionrepaircouplingfactormfdassociateswithrnapolymeraseintheabsenceofexogenousdamage
_version_	1718380663648813056

The transcription-repair coupling factor Mfd associates with RNA polymerase in the absence of exogenous damage

Ejemplares similares