Estimation of non-null SNP effect size distributions enables the detection of enriched genes underlying complex traits.
Traditional univariate genome-wide association studies generate false positives and negatives due to difficulties distinguishing associated variants from variants with spurious nonzero effects that do not directly influence the trait. Recent efforts have been directed at identifying genes or signali...
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| Main Authors: | , , |
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| Format: | article |
| Language: | EN |
| Published: |
Public Library of Science (PLoS)
2020
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| Subjects: | |
| Online Access: | https://doaj.org/article/2d111a8b08b84a2b92339b71397291b2 |
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