Secondary progressive and relapsing remitting multiple sclerosis leads to motor-related decreased anatomical connectivity.

Multiple sclerosis (MS) damages central white matter pathways which has considerable impact on disease-related disability. To identify disease-related alterations in anatomical connectivity, 34 patients (19 with relapsing remitting MS (RR-MS), 15 with secondary progressive MS (SP-MS) and 20 healthy...

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Autores principales:	Mark Lyksborg, Hartwig R Siebner, Per S Sørensen, Morten Blinkenberg, Geoff J M Parker, Anne-Marie Dogonowski, Ellen Garde, Rasmus Larsen, Tim B Dyrby
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2d129b071d564ab5a79f0943057fc57e
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spelling	oai:doaj.org-article:2d129b071d564ab5a79f0943057fc57e2021-11-18T08:22:27ZSecondary progressive and relapsing remitting multiple sclerosis leads to motor-related decreased anatomical connectivity.1932-620310.1371/journal.pone.0095540https://doaj.org/article/2d129b071d564ab5a79f0943057fc57e2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24748023/?tool=EBIhttps://doaj.org/toc/1932-6203Multiple sclerosis (MS) damages central white matter pathways which has considerable impact on disease-related disability. To identify disease-related alterations in anatomical connectivity, 34 patients (19 with relapsing remitting MS (RR-MS), 15 with secondary progressive MS (SP-MS) and 20 healthy subjects underwent diffusion magnetic resonance imaging (dMRI) of the brain. Based on the dMRI, anatomical connectivity mapping (ACM) yielded a voxel-based metric reflecting the connectivity shared between each individual voxel and all other brain voxels. To avoid biases caused by inter-individual brain-shape differences, they were estimated in a spatially normalized space. Voxel-based statistical analyses using ACM were compared with analyses based on the localized microstructural indices of fractional anisotropy (FA). In both RR-MS and SP-MS patients, considerable portions of the motor-related white matter revealed decreases in ACM and FA when compared with healthy subjects. Patients with SP-MS exhibited reduced ACM values relative to RR-MS in the motor-related tracts, whereas there were no consistent decreases in FA between SP-MS and RR-MS patients. Regional ACM statistics exhibited moderate correlation with clinical disability as reflected by the expanded disability status scale (EDSS). The correlation between these statistics and EDSS was either similar to or stronger than the correlation between FA statistics and the EDSS. Together, the results reveal an improved relationship between ACM, the clinical phenotype, and impairment. This highlights the potential of the ACM connectivity indices to be used as a marker which can identify disease related-alterations due to MS which may not be seen using localized microstructural indices.Mark LyksborgHartwig R SiebnerPer S SørensenMorten BlinkenbergGeoff J M ParkerAnne-Marie DogonowskiEllen GardeRasmus LarsenTim B DyrbyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 4, p e95540 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mark Lyksborg Hartwig R Siebner Per S Sørensen Morten Blinkenberg Geoff J M Parker Anne-Marie Dogonowski Ellen Garde Rasmus Larsen Tim B Dyrby Secondary progressive and relapsing remitting multiple sclerosis leads to motor-related decreased anatomical connectivity.
description	Multiple sclerosis (MS) damages central white matter pathways which has considerable impact on disease-related disability. To identify disease-related alterations in anatomical connectivity, 34 patients (19 with relapsing remitting MS (RR-MS), 15 with secondary progressive MS (SP-MS) and 20 healthy subjects underwent diffusion magnetic resonance imaging (dMRI) of the brain. Based on the dMRI, anatomical connectivity mapping (ACM) yielded a voxel-based metric reflecting the connectivity shared between each individual voxel and all other brain voxels. To avoid biases caused by inter-individual brain-shape differences, they were estimated in a spatially normalized space. Voxel-based statistical analyses using ACM were compared with analyses based on the localized microstructural indices of fractional anisotropy (FA). In both RR-MS and SP-MS patients, considerable portions of the motor-related white matter revealed decreases in ACM and FA when compared with healthy subjects. Patients with SP-MS exhibited reduced ACM values relative to RR-MS in the motor-related tracts, whereas there were no consistent decreases in FA between SP-MS and RR-MS patients. Regional ACM statistics exhibited moderate correlation with clinical disability as reflected by the expanded disability status scale (EDSS). The correlation between these statistics and EDSS was either similar to or stronger than the correlation between FA statistics and the EDSS. Together, the results reveal an improved relationship between ACM, the clinical phenotype, and impairment. This highlights the potential of the ACM connectivity indices to be used as a marker which can identify disease related-alterations due to MS which may not be seen using localized microstructural indices.
format	article
author	Mark Lyksborg Hartwig R Siebner Per S Sørensen Morten Blinkenberg Geoff J M Parker Anne-Marie Dogonowski Ellen Garde Rasmus Larsen Tim B Dyrby
author_facet	Mark Lyksborg Hartwig R Siebner Per S Sørensen Morten Blinkenberg Geoff J M Parker Anne-Marie Dogonowski Ellen Garde Rasmus Larsen Tim B Dyrby
author_sort	Mark Lyksborg
title	Secondary progressive and relapsing remitting multiple sclerosis leads to motor-related decreased anatomical connectivity.
title_short	Secondary progressive and relapsing remitting multiple sclerosis leads to motor-related decreased anatomical connectivity.
title_full	Secondary progressive and relapsing remitting multiple sclerosis leads to motor-related decreased anatomical connectivity.
title_fullStr	Secondary progressive and relapsing remitting multiple sclerosis leads to motor-related decreased anatomical connectivity.
title_full_unstemmed	Secondary progressive and relapsing remitting multiple sclerosis leads to motor-related decreased anatomical connectivity.
title_sort	secondary progressive and relapsing remitting multiple sclerosis leads to motor-related decreased anatomical connectivity.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/2d129b071d564ab5a79f0943057fc57e
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Secondary progressive and relapsing remitting multiple sclerosis leads to motor-related decreased anatomical connectivity.

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