Bitter taste receptor polymorphisms and human aging.

Several studies have shown that genetic factors account for 25% of the variation in human life span. On the basis of published molecular, genetic and epidemiological data, we hypothesized that genetic polymorphisms of taste receptors, which modulate food preferences but are also expressed in a numbe...

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Autores principales:	Daniele Campa, Francesco De Rango, Maura Carrai, Paolina Crocco, Alberto Montesanto, Federico Canzian, Giuseppina Rose, Cosmeri Rizzato, Giuseppe Passarino, Roberto Barale
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2d15465b1abd444b9aab5764738b9d8c
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spelling	oai:doaj.org-article:2d15465b1abd444b9aab5764738b9d8c2021-11-18T08:10:12ZBitter taste receptor polymorphisms and human aging.1932-620310.1371/journal.pone.0045232https://doaj.org/article/2d15465b1abd444b9aab5764738b9d8c2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23133589/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Several studies have shown that genetic factors account for 25% of the variation in human life span. On the basis of published molecular, genetic and epidemiological data, we hypothesized that genetic polymorphisms of taste receptors, which modulate food preferences but are also expressed in a number of organs and regulate food absorption processing and metabolism, could modulate the aging process. Using a tagging approach, we investigated the possible associations between longevity and the common genetic variation at the three bitter taste receptor gene clusters on chromosomes 5, 7 and 12 in a population of 941 individuals ranging in age from 20 to 106 years from the South of Italy. We found that one polymorphism, rs978739, situated 212 bp upstream of the TAS2R16 gene, shows a statistically significant association (p = 0.001) with longevity. In particular, the frequency of A/A homozygotes increases gradually from 35% in subjects aged 20 to 70 up to 55% in centenarians. These data provide suggestive evidence on the possible correlation between human longevity and taste genetics.Daniele CampaFrancesco De RangoMaura CarraiPaolina CroccoAlberto MontesantoFederico CanzianGiuseppina RoseCosmeri RizzatoGiuseppe PassarinoRoberto BaralePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e45232 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Daniele Campa Francesco De Rango Maura Carrai Paolina Crocco Alberto Montesanto Federico Canzian Giuseppina Rose Cosmeri Rizzato Giuseppe Passarino Roberto Barale Bitter taste receptor polymorphisms and human aging.
description	Several studies have shown that genetic factors account for 25% of the variation in human life span. On the basis of published molecular, genetic and epidemiological data, we hypothesized that genetic polymorphisms of taste receptors, which modulate food preferences but are also expressed in a number of organs and regulate food absorption processing and metabolism, could modulate the aging process. Using a tagging approach, we investigated the possible associations between longevity and the common genetic variation at the three bitter taste receptor gene clusters on chromosomes 5, 7 and 12 in a population of 941 individuals ranging in age from 20 to 106 years from the South of Italy. We found that one polymorphism, rs978739, situated 212 bp upstream of the TAS2R16 gene, shows a statistically significant association (p = 0.001) with longevity. In particular, the frequency of A/A homozygotes increases gradually from 35% in subjects aged 20 to 70 up to 55% in centenarians. These data provide suggestive evidence on the possible correlation between human longevity and taste genetics.
format	article
author	Daniele Campa Francesco De Rango Maura Carrai Paolina Crocco Alberto Montesanto Federico Canzian Giuseppina Rose Cosmeri Rizzato Giuseppe Passarino Roberto Barale
author_facet	Daniele Campa Francesco De Rango Maura Carrai Paolina Crocco Alberto Montesanto Federico Canzian Giuseppina Rose Cosmeri Rizzato Giuseppe Passarino Roberto Barale
author_sort	Daniele Campa
title	Bitter taste receptor polymorphisms and human aging.
title_short	Bitter taste receptor polymorphisms and human aging.
title_full	Bitter taste receptor polymorphisms and human aging.
title_fullStr	Bitter taste receptor polymorphisms and human aging.
title_full_unstemmed	Bitter taste receptor polymorphisms and human aging.
title_sort	bitter taste receptor polymorphisms and human aging.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/2d15465b1abd444b9aab5764738b9d8c
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Bitter taste receptor polymorphisms and human aging.

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