Human protein secretory pathway genes are expressed in a tissue-specific pattern to match processing demands of the secretome

Gene expression: The human protein secretion pathway is tissue specific The secretory pathway, an ubiquitous cellular machinery in human cells, is here shown to have tissue-specific characteristics. A research team led by Prof. Jens Nielsen at the Chalmers University of Technology performed a meta-a...

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Autores principales:	Amir Feizi, Francesco Gatto, Mathias Uhlen, Jens Nielsen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/2d15ac45066544f99e5aef0205713a93
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spelling	oai:doaj.org-article:2d15ac45066544f99e5aef0205713a932021-12-02T15:10:32ZHuman protein secretory pathway genes are expressed in a tissue-specific pattern to match processing demands of the secretome10.1038/s41540-017-0021-42056-7189https://doaj.org/article/2d15ac45066544f99e5aef0205713a932017-08-01T00:00:00Zhttps://doi.org/10.1038/s41540-017-0021-4https://doaj.org/toc/2056-7189Gene expression: The human protein secretion pathway is tissue specific The secretory pathway, an ubiquitous cellular machinery in human cells, is here shown to have tissue-specific characteristics. A research team led by Prof. Jens Nielsen at the Chalmers University of Technology performed a meta-analysis of the gene expressions of the secretory pathway’ component. They detected that even though most of these components are expressed in all tissues, there exist distinct components with fine-tuned expression. They further evaluated the functional link between the detected tuning and the processes that are demanded to make a set of tissue-specific proteins such as endocrine system hormones or their receptors. These findings open up a new avenue to understand the function of the secretion pathway in human tissues with possible applications for improving production of pharmaceutical proteins and getting more insight into the mechanisms underlying diseases such as diabetes that are connected with the endocrine system.Amir FeiziFrancesco GattoMathias UhlenJens NielsenNature PortfolioarticleBiology (General)QH301-705.5ENnpj Systems Biology and Applications, Vol 3, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Amir Feizi Francesco Gatto Mathias Uhlen Jens Nielsen Human protein secretory pathway genes are expressed in a tissue-specific pattern to match processing demands of the secretome
description	Gene expression: The human protein secretion pathway is tissue specific The secretory pathway, an ubiquitous cellular machinery in human cells, is here shown to have tissue-specific characteristics. A research team led by Prof. Jens Nielsen at the Chalmers University of Technology performed a meta-analysis of the gene expressions of the secretory pathway’ component. They detected that even though most of these components are expressed in all tissues, there exist distinct components with fine-tuned expression. They further evaluated the functional link between the detected tuning and the processes that are demanded to make a set of tissue-specific proteins such as endocrine system hormones or their receptors. These findings open up a new avenue to understand the function of the secretion pathway in human tissues with possible applications for improving production of pharmaceutical proteins and getting more insight into the mechanisms underlying diseases such as diabetes that are connected with the endocrine system.
format	article
author	Amir Feizi Francesco Gatto Mathias Uhlen Jens Nielsen
author_facet	Amir Feizi Francesco Gatto Mathias Uhlen Jens Nielsen
author_sort	Amir Feizi
title	Human protein secretory pathway genes are expressed in a tissue-specific pattern to match processing demands of the secretome
title_short	Human protein secretory pathway genes are expressed in a tissue-specific pattern to match processing demands of the secretome
title_full	Human protein secretory pathway genes are expressed in a tissue-specific pattern to match processing demands of the secretome
title_fullStr	Human protein secretory pathway genes are expressed in a tissue-specific pattern to match processing demands of the secretome
title_full_unstemmed	Human protein secretory pathway genes are expressed in a tissue-specific pattern to match processing demands of the secretome
title_sort	human protein secretory pathway genes are expressed in a tissue-specific pattern to match processing demands of the secretome
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2d15ac45066544f99e5aef0205713a93
work_keys_str_mv	AT amirfeizi humanproteinsecretorypathwaygenesareexpressedinatissuespecificpatterntomatchprocessingdemandsofthesecretome AT francescogatto humanproteinsecretorypathwaygenesareexpressedinatissuespecificpatterntomatchprocessingdemandsofthesecretome AT mathiasuhlen humanproteinsecretorypathwaygenesareexpressedinatissuespecificpatterntomatchprocessingdemandsofthesecretome AT jensnielsen humanproteinsecretorypathwaygenesareexpressedinatissuespecificpatterntomatchprocessingdemandsofthesecretome
_version_	1718387681125203968

Human protein secretory pathway genes are expressed in a tissue-specific pattern to match processing demands of the secretome

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