Importance of cardiovascular disease risk management in patients with type 2 diabetes mellitus

Daniel Lorber Division of Endocrinology, New York Hospital Queens, Department of Medicine, Weill Medical College of Cornell University, New York, NY, USA Abstract: Type 2 diabetes mellitus (T2DM) is commonly accompanied by other cardiovascular disease (CVD) risk factors, such as hypertension, obes...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autor principal:	Lorber D
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/2d1687548a0c40f4aedef0f84be0c23d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2d1687548a0c40f4aedef0f84be0c23d
record_format	dspace
spelling	oai:doaj.org-article:2d1687548a0c40f4aedef0f84be0c23d2021-12-02T06:25:11ZImportance of cardiovascular disease risk management in patients with type 2 diabetes mellitus1178-7007https://doaj.org/article/2d1687548a0c40f4aedef0f84be0c23d2014-05-01T00:00:00Zhttp://www.dovepress.com/importance-of-cardiovascular-disease-risk-management-in-patients-with--a16973https://doaj.org/toc/1178-7007 Daniel Lorber Division of Endocrinology, New York Hospital Queens, Department of Medicine, Weill Medical College of Cornell University, New York, NY, USA Abstract: Type 2 diabetes mellitus (T2DM) is commonly accompanied by other cardiovascular disease (CVD) risk factors, such as hypertension, obesity, and dyslipidemia. Furthermore, CVD is the most common cause of death in people with T2DM. It is therefore of critical importance to minimize the risk of macrovascular complications by carefully managing modifiable CVD risk factors in patients with T2DM. Therapeutic strategies should include lifestyle and pharmacological interventions targeting hyperglycemia, hypertension, dyslipidemia, obesity, cigarette smoking, physical inactivity, and prothrombotic factors. This article discusses the impact of modifying these CVD risk factors in the context of T2DM; the clinical evidence is summarized, and current guidelines are also discussed. The cardiovascular benefits of smoking cessation, increasing physical activity, and reducing low-density lipoprotein cholesterol and blood pressure are well established. For aspirin therapy, any cardiovascular benefits must be balanced against the associated bleeding risk, with current evidence supporting this strategy only in certain patients who are at increased CVD risk. Although overweight, obesity, and hyperglycemia are clearly associated with increased cardiovascular risk, the effect of their modification on this risk is less well defined by available clinical trial evidence. However, for glucose-lowering drugs, further evidence is expected from several ongoing cardiovascular outcome trials. Taken together, the evidence highlights the value of early intervention and targeting multiple risk factors with both lifestyle and pharmacological strategies to give the best chance of reducing macrovascular complications in the long term. Keywords: cardiovascular risk, hypertension, obesity, dyslipidemiaLorber DDove Medical PressarticleSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2014, Iss default, Pp 169-183 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Specialties of internal medicine RC581-951
spellingShingle	Specialties of internal medicine RC581-951 Lorber D Importance of cardiovascular disease risk management in patients with type 2 diabetes mellitus
description	Daniel Lorber Division of Endocrinology, New York Hospital Queens, Department of Medicine, Weill Medical College of Cornell University, New York, NY, USA Abstract: Type 2 diabetes mellitus (T2DM) is commonly accompanied by other cardiovascular disease (CVD) risk factors, such as hypertension, obesity, and dyslipidemia. Furthermore, CVD is the most common cause of death in people with T2DM. It is therefore of critical importance to minimize the risk of macrovascular complications by carefully managing modifiable CVD risk factors in patients with T2DM. Therapeutic strategies should include lifestyle and pharmacological interventions targeting hyperglycemia, hypertension, dyslipidemia, obesity, cigarette smoking, physical inactivity, and prothrombotic factors. This article discusses the impact of modifying these CVD risk factors in the context of T2DM; the clinical evidence is summarized, and current guidelines are also discussed. The cardiovascular benefits of smoking cessation, increasing physical activity, and reducing low-density lipoprotein cholesterol and blood pressure are well established. For aspirin therapy, any cardiovascular benefits must be balanced against the associated bleeding risk, with current evidence supporting this strategy only in certain patients who are at increased CVD risk. Although overweight, obesity, and hyperglycemia are clearly associated with increased cardiovascular risk, the effect of their modification on this risk is less well defined by available clinical trial evidence. However, for glucose-lowering drugs, further evidence is expected from several ongoing cardiovascular outcome trials. Taken together, the evidence highlights the value of early intervention and targeting multiple risk factors with both lifestyle and pharmacological strategies to give the best chance of reducing macrovascular complications in the long term. Keywords: cardiovascular risk, hypertension, obesity, dyslipidemia
format	article
author	Lorber D
author_facet	Lorber D
author_sort	Lorber D
title	Importance of cardiovascular disease risk management in patients with type 2 diabetes mellitus
title_short	Importance of cardiovascular disease risk management in patients with type 2 diabetes mellitus
title_full	Importance of cardiovascular disease risk management in patients with type 2 diabetes mellitus
title_fullStr	Importance of cardiovascular disease risk management in patients with type 2 diabetes mellitus
title_full_unstemmed	Importance of cardiovascular disease risk management in patients with type 2 diabetes mellitus
title_sort	importance of cardiovascular disease risk management in patients with type 2 diabetes mellitus
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/2d1687548a0c40f4aedef0f84be0c23d
work_keys_str_mv	AT lorberd importanceofcardiovasculardiseaseriskmanagementinpatientswithtype2diabetesmellitus
_version_	1718399924158070784

Importance of cardiovascular disease risk management in patients with type 2 diabetes mellitus

Ejemplares similares