Multi-Stimuli-Responsive DOX Released from Magnetosome for Tumor Synergistic Theranostics

Ming-Fong Tsai,1,* Yu-Lun Lo,1,* Yuan-Chun Huang,1 Chun-Chieh Yu,2 Yi-Ting Wu,1 Chia-Hao Su,2,3 Li-Fang Wang1,4 1Department of Medicinal & Applied Chemistry, College of Life Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan; 2Institute for Translational Research in Biomedicine, K...

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Autores principales:	Tsai MF, Lo YL, Huang YC, Yu CC, Wu YT, Su CH, Wang LF
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	magnetosome multi-stimuli-responsive copolymer theranostics hyperthermia magnetic resonance imaging Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2d17b89c7e3c43e688c12ba641946234
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spelling	oai:doaj.org-article:2d17b89c7e3c43e688c12ba6419462342021-12-02T12:25:58ZMulti-Stimuli-Responsive DOX Released from Magnetosome for Tumor Synergistic Theranostics1178-2013https://doaj.org/article/2d17b89c7e3c43e688c12ba6419462342020-11-01T00:00:00Zhttps://www.dovepress.com/multi-stimuli-responsive-dox-released-from-magnetosome-for-tumor-syner-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Ming-Fong Tsai,1,* Yu-Lun Lo,1,* Yuan-Chun Huang,1 Chun-Chieh Yu,2 Yi-Ting Wu,1 Chia-Hao Su,2,3 Li-Fang Wang1,4 1Department of Medicinal & Applied Chemistry, College of Life Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan; 2Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan; 3Department of Biomedical Imaging and Radiological Sciences, National Yang Ming University, Taipei 112, Taiwan; 4Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan*These authors contributed equally to this workCorrespondence: Li-Fang WangDepartment of Medicinal & Applied Chemistry, College of Life Sciences, Kaohsiung Medical University, 100 Shih-Chuan 1st Road, Kaohsiung 80708, TaiwanTel +886-7-312-1101 Ext. 2217Fax +886-7-312-5339Email lfwang@kmu.edu.twChia-Hao SuProfessor of Molecular Imaging & Nanotechnology, Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, 123 Dapi Road, Niaosong District, Kaohsiung 83301, TaiwanTel +886-7-731-7123 Ext. 8592Fax +886-7-731-7123 Ext. 8569Email chiralsu@gmail.comBackground: To improve responses to tumor microenvironments for achieving a better therapeutic outcome in combination cancer therapy, poly(ϵ-caprolactone)-SS-poly(methacrylic acid) diblock copolymer (PCL-SS-PMAA) with a disulfide linkage between the hydrophobic and hydrophilic junctions was synthesized.Materials and Methods: Repeating units of PCL and PMAA in PCL-SS-PMAA were controlled and formulated into polymersomes (PSPps). Truncated octahedral Fe3O4 nanoparticles (IONPs) were synthesized and encapsulated to produce IONPs-PSPps NPs and doxorubicin (DOX) was further loaded to produce IONPs-PSPps@DOX NPs for theranostic applications.Results: IONPs-PSPps NPs remained a superparamagnetic property with a saturation magnetization value of 85 emu⋅gFe3O4− 1 and a relaxivity value of 180 mM− 1⋅s− 1. Upon exposure to an alternating magnetic field (AMF), IONPs-PSPps NPs increased temperature from 25°C to 54°C within 15 min. Among test groups, the cell apoptosis was greatest in the group exposed to IONPs-PSPps@DOX NPs with AMF and magnet assistance. In vivo T2-weighted magnetic resonance images of A549 tumor-bearing mice also showed highest contrast and greatest tumor suppression in the tumor with AMF and magnet assistance.Conclusion: IONPs-PSPps@DOX NPs are a potential theranostic agent having multifaceted applications involving magnetic targeting, MRI diagnosis, hyperthermia and chemotherapy.Keywords: magnetosome, multi-stimuli-responsive copolymer, theranostics, hyperthermia, magnetic resonance imagingTsai MFLo YLHuang YCYu CCWu YTSu CHWang LFDove Medical Pressarticlemagnetosomemulti-stimuli-responsive copolymertheranosticshyperthermiamagnetic resonance imagingMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 8623-8639 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	magnetosome multi-stimuli-responsive copolymer theranostics hyperthermia magnetic resonance imaging Medicine (General) R5-920
spellingShingle	magnetosome multi-stimuli-responsive copolymer theranostics hyperthermia magnetic resonance imaging Medicine (General) R5-920 Tsai MF Lo YL Huang YC Yu CC Wu YT Su CH Wang LF Multi-Stimuli-Responsive DOX Released from Magnetosome for Tumor Synergistic Theranostics
description	Ming-Fong Tsai,1,* Yu-Lun Lo,1,* Yuan-Chun Huang,1 Chun-Chieh Yu,2 Yi-Ting Wu,1 Chia-Hao Su,2,3 Li-Fang Wang1,4 1Department of Medicinal & Applied Chemistry, College of Life Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan; 2Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan; 3Department of Biomedical Imaging and Radiological Sciences, National Yang Ming University, Taipei 112, Taiwan; 4Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan*These authors contributed equally to this workCorrespondence: Li-Fang WangDepartment of Medicinal & Applied Chemistry, College of Life Sciences, Kaohsiung Medical University, 100 Shih-Chuan 1st Road, Kaohsiung 80708, TaiwanTel +886-7-312-1101 Ext. 2217Fax +886-7-312-5339Email lfwang@kmu.edu.twChia-Hao SuProfessor of Molecular Imaging & Nanotechnology, Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, 123 Dapi Road, Niaosong District, Kaohsiung 83301, TaiwanTel +886-7-731-7123 Ext. 8592Fax +886-7-731-7123 Ext. 8569Email chiralsu@gmail.comBackground: To improve responses to tumor microenvironments for achieving a better therapeutic outcome in combination cancer therapy, poly(ϵ-caprolactone)-SS-poly(methacrylic acid) diblock copolymer (PCL-SS-PMAA) with a disulfide linkage between the hydrophobic and hydrophilic junctions was synthesized.Materials and Methods: Repeating units of PCL and PMAA in PCL-SS-PMAA were controlled and formulated into polymersomes (PSPps). Truncated octahedral Fe3O4 nanoparticles (IONPs) were synthesized and encapsulated to produce IONPs-PSPps NPs and doxorubicin (DOX) was further loaded to produce IONPs-PSPps@DOX NPs for theranostic applications.Results: IONPs-PSPps NPs remained a superparamagnetic property with a saturation magnetization value of 85 emu⋅gFe3O4− 1 and a relaxivity value of 180 mM− 1⋅s− 1. Upon exposure to an alternating magnetic field (AMF), IONPs-PSPps NPs increased temperature from 25°C to 54°C within 15 min. Among test groups, the cell apoptosis was greatest in the group exposed to IONPs-PSPps@DOX NPs with AMF and magnet assistance. In vivo T2-weighted magnetic resonance images of A549 tumor-bearing mice also showed highest contrast and greatest tumor suppression in the tumor with AMF and magnet assistance.Conclusion: IONPs-PSPps@DOX NPs are a potential theranostic agent having multifaceted applications involving magnetic targeting, MRI diagnosis, hyperthermia and chemotherapy.Keywords: magnetosome, multi-stimuli-responsive copolymer, theranostics, hyperthermia, magnetic resonance imaging
format	article
author	Tsai MF Lo YL Huang YC Yu CC Wu YT Su CH Wang LF
author_facet	Tsai MF Lo YL Huang YC Yu CC Wu YT Su CH Wang LF
author_sort	Tsai MF
title	Multi-Stimuli-Responsive DOX Released from Magnetosome for Tumor Synergistic Theranostics
title_short	Multi-Stimuli-Responsive DOX Released from Magnetosome for Tumor Synergistic Theranostics
title_full	Multi-Stimuli-Responsive DOX Released from Magnetosome for Tumor Synergistic Theranostics
title_fullStr	Multi-Stimuli-Responsive DOX Released from Magnetosome for Tumor Synergistic Theranostics
title_full_unstemmed	Multi-Stimuli-Responsive DOX Released from Magnetosome for Tumor Synergistic Theranostics
title_sort	multi-stimuli-responsive dox released from magnetosome for tumor synergistic theranostics
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/2d17b89c7e3c43e688c12ba641946234
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Multi-Stimuli-Responsive DOX Released from Magnetosome for Tumor Synergistic Theranostics

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