Case Report: Clostridium neonatale Bacteremia in a Preterm Neonate With Necrotizing Enterocolitis

Necrotizing enterocolitis is a life-threatening acquired gastrointestinal disorder among preterm neonates and is associated with a high mortality rate and long-term neurodevelopmental morbidity. No etiologic agent has been definitively established; nonetheless, the most implicated bacteria include m...

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Autores principales:	Nadim Cassir, Isabelle Grandvuillemin, Manon Boxberger, Priscilla Jardot, Farid Boubred, Bernard La Scola
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	case report necrotizing enterocolitis preterm neonate Clostridium neonatale gut microbiota Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/2d1d3973c4604e7bad0928ff390727d5
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spelling	oai:doaj.org-article:2d1d3973c4604e7bad0928ff390727d52021-12-02T10:36:25ZCase Report: Clostridium neonatale Bacteremia in a Preterm Neonate With Necrotizing Enterocolitis2296-236010.3389/fped.2021.771467https://doaj.org/article/2d1d3973c4604e7bad0928ff390727d52021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fped.2021.771467/fullhttps://doaj.org/toc/2296-2360Necrotizing enterocolitis is a life-threatening acquired gastrointestinal disorder among preterm neonates and is associated with a high mortality rate and long-term neurodevelopmental morbidity. No etiologic agent has been definitively established; nonetheless, the most implicated bacteria include members of the Clostridium genus. We reported here on a case of Clostridium neonatale bacteremia in a preterm neonate with necrotizing enterocolitis, providing more information regarding the potential role of this bacterium in pathogenesis of necrotizing enterocolitis. We emphasized the sporulating form of C. neonatale that confers resistance to disinfectants usually applied for the hospital environmental cleaning. Further works are needed to establish the causal relationship between the occurrence of NEC and the isolation of C. neonatale, with promising perspectives in terms of diagnostic and therapeutic management.Nadim CassirNadim CassirIsabelle GrandvuilleminManon BoxbergerManon BoxbergerPriscilla JardotPriscilla JardotFarid BoubredFarid BoubredBernard La ScolaBernard La ScolaFrontiers Media S.A.articlecase reportnecrotizing enterocolitispreterm neonateClostridium neonatalegut microbiotaPediatricsRJ1-570ENFrontiers in Pediatrics, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	case report necrotizing enterocolitis preterm neonate Clostridium neonatale gut microbiota Pediatrics RJ1-570
spellingShingle	case report necrotizing enterocolitis preterm neonate Clostridium neonatale gut microbiota Pediatrics RJ1-570 Nadim Cassir Nadim Cassir Isabelle Grandvuillemin Manon Boxberger Manon Boxberger Priscilla Jardot Priscilla Jardot Farid Boubred Farid Boubred Bernard La Scola Bernard La Scola Case Report: Clostridium neonatale Bacteremia in a Preterm Neonate With Necrotizing Enterocolitis
description	Necrotizing enterocolitis is a life-threatening acquired gastrointestinal disorder among preterm neonates and is associated with a high mortality rate and long-term neurodevelopmental morbidity. No etiologic agent has been definitively established; nonetheless, the most implicated bacteria include members of the Clostridium genus. We reported here on a case of Clostridium neonatale bacteremia in a preterm neonate with necrotizing enterocolitis, providing more information regarding the potential role of this bacterium in pathogenesis of necrotizing enterocolitis. We emphasized the sporulating form of C. neonatale that confers resistance to disinfectants usually applied for the hospital environmental cleaning. Further works are needed to establish the causal relationship between the occurrence of NEC and the isolation of C. neonatale, with promising perspectives in terms of diagnostic and therapeutic management.
format	article
author	Nadim Cassir Nadim Cassir Isabelle Grandvuillemin Manon Boxberger Manon Boxberger Priscilla Jardot Priscilla Jardot Farid Boubred Farid Boubred Bernard La Scola Bernard La Scola
author_facet	Nadim Cassir Nadim Cassir Isabelle Grandvuillemin Manon Boxberger Manon Boxberger Priscilla Jardot Priscilla Jardot Farid Boubred Farid Boubred Bernard La Scola Bernard La Scola
author_sort	Nadim Cassir
title	Case Report: Clostridium neonatale Bacteremia in a Preterm Neonate With Necrotizing Enterocolitis
title_short	Case Report: Clostridium neonatale Bacteremia in a Preterm Neonate With Necrotizing Enterocolitis
title_full	Case Report: Clostridium neonatale Bacteremia in a Preterm Neonate With Necrotizing Enterocolitis
title_fullStr	Case Report: Clostridium neonatale Bacteremia in a Preterm Neonate With Necrotizing Enterocolitis
title_full_unstemmed	Case Report: Clostridium neonatale Bacteremia in a Preterm Neonate With Necrotizing Enterocolitis
title_sort	case report: clostridium neonatale bacteremia in a preterm neonate with necrotizing enterocolitis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/2d1d3973c4604e7bad0928ff390727d5
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Case Report: Clostridium neonatale Bacteremia in a Preterm Neonate With Necrotizing Enterocolitis

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