Poly (lactic-co-glycolic acid)/graphene oxide composites combined with electrical stimulation in wound healing: preparation and characterization

Di You,1 Kai Li,1 Wenlai Guo,2 Guoqing Zhao,1 Chuan Fu11Department of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun 130033, People’s Republic of China; 2Department of Hand and Foot Surgery, The Second Hospital of Jilin University, Changchun 130012, People&rs...

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Autores principales:	You D, Li K, Guo W, Zhao G, Fu C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	wound repair graphene oxide electrical stimulation tissue engineering PLGA Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2d25df049c6543a29167855043c55e92
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spelling	oai:doaj.org-article:2d25df049c6543a29167855043c55e922021-12-02T04:07:53ZPoly (lactic-co-glycolic acid)/graphene oxide composites combined with electrical stimulation in wound healing: preparation and characterization1178-2013https://doaj.org/article/2d25df049c6543a29167855043c55e922019-08-01T00:00:00Zhttps://www.dovepress.com/poly-lactic-co-glycolic-acidgraphene-oxide-composites-combined-with-el-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Di You,1 Kai Li,1 Wenlai Guo,2 Guoqing Zhao,1 Chuan Fu11Department of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun 130033, People’s Republic of China; 2Department of Hand and Foot Surgery, The Second Hospital of Jilin University, Changchun 130012, People’s Republic of ChinaCorrespondence: Guoqing Zhao; Chuan FuDepartment of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun 130033, People’s Republic of ChinaTel +86 1 350 088 6187; +86 1 575 430 6089Fax +86 04 318 499 5299Email guoqingzhao1965@163.com; fuchuan2015@163.comPurpose: In this study, we fabricated multifunctional, electrically conductive composites by incorporating graphene oxide (GO) into a poly (lactic-co-glycolic acid) (PLGA) copolymer for wound repair. Furthermore, the resultant composites were coupled with electrical stimulation to further improve the therapeutic effect of wound repair.Methods: We evaluated the surface morphology of the composites, as well as their physical properties, cytotoxicity, and antibacterial activity, along with the combined effects of composites and electrical stimulation (ES) in a rat model of wound healing.Results: Application of the PLGA/GO composites to full-thickness wounds confirmed their advantageous biological properties, as evident from the observed improvements in wound-specific mechanical properties, biocompatibility, and antibacterial activity. Additionally, we found that the combination of composites and ES improved composite-mediated cell survival and accelerated wound healing in vivo by promoting neovascularization and the formation of type I collagen.Conclusion: These results demonstrated that combined treatment with the PLGA/GO composite and ES promoted vascularization and epidermal remodeling and accelerated wound healing in rats, thereby suggesting the efficacy of PLGA/GO+ES for broad applications associated with wound repair.Keywords: wound repair, graphene oxide, electrical stimulation, tissue engineering, PLGAYou DLi KGuo WZhao GFu CDove Medical Pressarticlewound repairgraphene oxideelectrical stimulationtissue engineeringPLGAMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 7039-7052 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	wound repair graphene oxide electrical stimulation tissue engineering PLGA Medicine (General) R5-920
spellingShingle	wound repair graphene oxide electrical stimulation tissue engineering PLGA Medicine (General) R5-920 You D Li K Guo W Zhao G Fu C Poly (lactic-co-glycolic acid)/graphene oxide composites combined with electrical stimulation in wound healing: preparation and characterization
description	Di You,1 Kai Li,1 Wenlai Guo,2 Guoqing Zhao,1 Chuan Fu11Department of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun 130033, People’s Republic of China; 2Department of Hand and Foot Surgery, The Second Hospital of Jilin University, Changchun 130012, People’s Republic of ChinaCorrespondence: Guoqing Zhao; Chuan FuDepartment of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun 130033, People’s Republic of ChinaTel +86 1 350 088 6187; +86 1 575 430 6089Fax +86 04 318 499 5299Email guoqingzhao1965@163.com; fuchuan2015@163.comPurpose: In this study, we fabricated multifunctional, electrically conductive composites by incorporating graphene oxide (GO) into a poly (lactic-co-glycolic acid) (PLGA) copolymer for wound repair. Furthermore, the resultant composites were coupled with electrical stimulation to further improve the therapeutic effect of wound repair.Methods: We evaluated the surface morphology of the composites, as well as their physical properties, cytotoxicity, and antibacterial activity, along with the combined effects of composites and electrical stimulation (ES) in a rat model of wound healing.Results: Application of the PLGA/GO composites to full-thickness wounds confirmed their advantageous biological properties, as evident from the observed improvements in wound-specific mechanical properties, biocompatibility, and antibacterial activity. Additionally, we found that the combination of composites and ES improved composite-mediated cell survival and accelerated wound healing in vivo by promoting neovascularization and the formation of type I collagen.Conclusion: These results demonstrated that combined treatment with the PLGA/GO composite and ES promoted vascularization and epidermal remodeling and accelerated wound healing in rats, thereby suggesting the efficacy of PLGA/GO+ES for broad applications associated with wound repair.Keywords: wound repair, graphene oxide, electrical stimulation, tissue engineering, PLGA
format	article
author	You D Li K Guo W Zhao G Fu C
author_facet	You D Li K Guo W Zhao G Fu C
author_sort	You D
title	Poly (lactic-co-glycolic acid)/graphene oxide composites combined with electrical stimulation in wound healing: preparation and characterization
title_short	Poly (lactic-co-glycolic acid)/graphene oxide composites combined with electrical stimulation in wound healing: preparation and characterization
title_full	Poly (lactic-co-glycolic acid)/graphene oxide composites combined with electrical stimulation in wound healing: preparation and characterization
title_fullStr	Poly (lactic-co-glycolic acid)/graphene oxide composites combined with electrical stimulation in wound healing: preparation and characterization
title_full_unstemmed	Poly (lactic-co-glycolic acid)/graphene oxide composites combined with electrical stimulation in wound healing: preparation and characterization
title_sort	poly (lactic-co-glycolic acid)/graphene oxide composites combined with electrical stimulation in wound healing: preparation and characterization
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/2d25df049c6543a29167855043c55e92
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Poly (lactic-co-glycolic acid)/graphene oxide composites combined with electrical stimulation in wound healing: preparation and characterization

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