Osseointegration of nanohydroxyapatite- or nano-calcium silicate-incorporated polyetheretherketone bioactive composites in vivo

Rui Ma,1,2 Zhifeng Yu,1 Songchao Tang,3 Yongkang Pan,3 Jie Wei,3 Tingting Tang1 1Shanghai Key Laboratory of Orthopedic Implants, Department of Orthopedic Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Repu...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ma R, Yu Z, Tang S, Pan Y, Wei J, Tang T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	polyetheretherketone composite osseointegration hydroxyapatite calcium silicate Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2d266ea8d4204cfcb40861d3d493156e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2d266ea8d4204cfcb40861d3d493156e
record_format	dspace
spelling	oai:doaj.org-article:2d266ea8d4204cfcb40861d3d493156e2021-12-02T04:21:10ZOsseointegration of nanohydroxyapatite- or nano-calcium silicate-incorporated polyetheretherketone bioactive composites in vivo1178-2013https://doaj.org/article/2d266ea8d4204cfcb40861d3d493156e2016-11-01T00:00:00Zhttps://www.dovepress.com/osseointegration-of-nanohydroxyapatite--or-nano-calcium-silicate-incor-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Rui Ma,1,2 Zhifeng Yu,1 Songchao Tang,3 Yongkang Pan,3 Jie Wei,3 Tingting Tang1 1Shanghai Key Laboratory of Orthopedic Implants, Department of Orthopedic Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 2Department of Orthopedic Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shanxi Province, People’s Republic of China; 3Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, People’s Republic of China Abstract: Polyetheretherketone (PEEK) exhibits appropriate biomechanical strength as well as good biocompatibility and stable chemical properties but lacks bioactivity and cannot achieve highly efficient osseointegration after implantation. Incorporating bioceramics into the PEEK matrix is a feasible approach for improving its bioactivity. In this study, nanohydroxyapatite (n-HA) and nano-calcium silicate (n-CS) were separately incorporated into PEEK to prepare n-HA/PEEK and n-CS/PEEK biocomposites, respectively, using a compounding and injection-molding technique, and the in vitro degradation characteristics were evaluated. Discs with a diameter of 8 mm were inserted in 8 mm full-thickness cranial defects in rabbits for 4 and 8 weeks, and implantation of pure PEEK was used as the control. Three-dimensional microcomputed tomography, histological analysis, fluorescence microscopy of new bone formation, and scanning electron microscopy were used to evaluate the osseointegration performance at the bone/implant interface. The results of the in vitro degradation study demonstrated that degradation of n-CS on the surface of n-CS/PEEK could release Ca and Si ions and form a porous structure. In vivo tests revealed that both n-CS/PEEK and n-HA/PEEK promoted osseointegration at the bone/implant interface compared to PEEK, and n-CS/PEEK exhibited higher bone contact ratio and more new bone formation compared with those of n-HA/PEEK, implying that n-CS/PEEK possessed a stronger ability to promote osseointegration. These two PEEK biocomposites are promising materials for the preparation of orthopedic or craniofacial implants. Keywords: polyetheretherketone, composite, osseointegration, hydroxyapatite, calcium silicateMa RYu ZTang SPan YWei JTang TDove Medical Pressarticlepolyetheretherketonecompositeosseointegrationhydroxyapatitecalcium silicateMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 11, Pp 6023-6033 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	polyetheretherketone composite osseointegration hydroxyapatite calcium silicate Medicine (General) R5-920
spellingShingle	polyetheretherketone composite osseointegration hydroxyapatite calcium silicate Medicine (General) R5-920 Ma R Yu Z Tang S Pan Y Wei J Tang T Osseointegration of nanohydroxyapatite- or nano-calcium silicate-incorporated polyetheretherketone bioactive composites in vivo
description	Rui Ma,1,2 Zhifeng Yu,1 Songchao Tang,3 Yongkang Pan,3 Jie Wei,3 Tingting Tang1 1Shanghai Key Laboratory of Orthopedic Implants, Department of Orthopedic Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 2Department of Orthopedic Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shanxi Province, People’s Republic of China; 3Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, People’s Republic of China Abstract: Polyetheretherketone (PEEK) exhibits appropriate biomechanical strength as well as good biocompatibility and stable chemical properties but lacks bioactivity and cannot achieve highly efficient osseointegration after implantation. Incorporating bioceramics into the PEEK matrix is a feasible approach for improving its bioactivity. In this study, nanohydroxyapatite (n-HA) and nano-calcium silicate (n-CS) were separately incorporated into PEEK to prepare n-HA/PEEK and n-CS/PEEK biocomposites, respectively, using a compounding and injection-molding technique, and the in vitro degradation characteristics were evaluated. Discs with a diameter of 8 mm were inserted in 8 mm full-thickness cranial defects in rabbits for 4 and 8 weeks, and implantation of pure PEEK was used as the control. Three-dimensional microcomputed tomography, histological analysis, fluorescence microscopy of new bone formation, and scanning electron microscopy were used to evaluate the osseointegration performance at the bone/implant interface. The results of the in vitro degradation study demonstrated that degradation of n-CS on the surface of n-CS/PEEK could release Ca and Si ions and form a porous structure. In vivo tests revealed that both n-CS/PEEK and n-HA/PEEK promoted osseointegration at the bone/implant interface compared to PEEK, and n-CS/PEEK exhibited higher bone contact ratio and more new bone formation compared with those of n-HA/PEEK, implying that n-CS/PEEK possessed a stronger ability to promote osseointegration. These two PEEK biocomposites are promising materials for the preparation of orthopedic or craniofacial implants. Keywords: polyetheretherketone, composite, osseointegration, hydroxyapatite, calcium silicate
format	article
author	Ma R Yu Z Tang S Pan Y Wei J Tang T
author_facet	Ma R Yu Z Tang S Pan Y Wei J Tang T
author_sort	Ma R
title	Osseointegration of nanohydroxyapatite- or nano-calcium silicate-incorporated polyetheretherketone bioactive composites in vivo
title_short	Osseointegration of nanohydroxyapatite- or nano-calcium silicate-incorporated polyetheretherketone bioactive composites in vivo
title_full	Osseointegration of nanohydroxyapatite- or nano-calcium silicate-incorporated polyetheretherketone bioactive composites in vivo
title_fullStr	Osseointegration of nanohydroxyapatite- or nano-calcium silicate-incorporated polyetheretherketone bioactive composites in vivo
title_full_unstemmed	Osseointegration of nanohydroxyapatite- or nano-calcium silicate-incorporated polyetheretherketone bioactive composites in vivo
title_sort	osseointegration of nanohydroxyapatite- or nano-calcium silicate-incorporated polyetheretherketone bioactive composites in vivo
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/2d266ea8d4204cfcb40861d3d493156e
work_keys_str_mv	AT mar osseointegrationofnanohydroxyapatiteornanocalciumsilicateincorporatedpolyetheretherketonebioactivecompositesinvivo AT yuz osseointegrationofnanohydroxyapatiteornanocalciumsilicateincorporatedpolyetheretherketonebioactivecompositesinvivo AT tangs osseointegrationofnanohydroxyapatiteornanocalciumsilicateincorporatedpolyetheretherketonebioactivecompositesinvivo AT pany osseointegrationofnanohydroxyapatiteornanocalciumsilicateincorporatedpolyetheretherketonebioactivecompositesinvivo AT weij osseointegrationofnanohydroxyapatiteornanocalciumsilicateincorporatedpolyetheretherketonebioactivecompositesinvivo AT tangt osseointegrationofnanohydroxyapatiteornanocalciumsilicateincorporatedpolyetheretherketonebioactivecompositesinvivo
_version_	1718401300479082496

Osseointegration of nanohydroxyapatite- or nano-calcium silicate-incorporated polyetheretherketone bioactive composites in vivo

Ejemplares similares