Leptin Induces Apoptotic and Pyroptotic Cell Death via NLRP3 Inflammasome Activation in Rat Hepatocytes
Leptin, a hormone that is predominantly produced by adipose tissue, is closely associated with various liver diseases. However, there is a lack of understanding as to whether leptin directly induces cytotoxic effects in hepatocytes as well as the mechanisms that are involved. Inflammasomes, which ar...
Guardado en:
Autores principales: | Ananda Baral, Pil-Hoon Park |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
MDPI AG
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/2d272c674d1046009f693b32b28fb8a8 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Dysfunction of various organelles provokes multiple cell death after quantum dot exposure
por: Wang Y, et al.
Publicado: (2018) -
Ochratoxin A induces NLRP3 inflammasome-mediated pyroptosis via activation of ROS modulated by autophagy in vitro
por: Kai Liu, et al.
Publicado: (2021) -
Salubrinal abrogates palmitate-induced leptin resistance and endoplasmic reticulum stress via nuclear factor kappa-light-chain-enhancer of activated B cell pathway in mHypoE-44 hypothalamic neurons
por: Zhang M, et al.
Publicado: (2018) -
Silica nanoparticles induce autophagy dysfunction via lysosomal impairment and inhibition of autophagosome degradation in hepatocytes
por: Wang J, et al.
Publicado: (2017) -
Leptin resistance: underlying mechanisms and diagnosis
por: Gruzdeva O, et al.
Publicado: (2019)