Concentration profiles of ions and particles under hydrodynamic focusing in Y-shaped square microchannel

Abstract Three-dimensional ion and particle concentrations under hydrodynamic focusing in a Y-shaped square microchannel are numerically simulated to clarify the decrease of the ion concentration along the flow direction within the focused particle stream. The simulation model is theoretically gover...

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Autores principales:	Norikazu Sato, Daisuke Kawashima, Masahiro Takei
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2d273d57c3ff43968e600571f4ca2f0d
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spelling	oai:doaj.org-article:2d273d57c3ff43968e600571f4ca2f0d2021-12-02T13:24:26ZConcentration profiles of ions and particles under hydrodynamic focusing in Y-shaped square microchannel10.1038/s41598-021-82259-42045-2322https://doaj.org/article/2d273d57c3ff43968e600571f4ca2f0d2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82259-4https://doaj.org/toc/2045-2322Abstract Three-dimensional ion and particle concentrations under hydrodynamic focusing in a Y-shaped square microchannel are numerically simulated to clarify the decrease of the ion concentration along the flow direction within the focused particle stream. The simulation model is theoretically governed by the laminar flow and advection–diffusion equations. The governing equations are solved by the finite volume method. The ion and particle concentration distributions at five cross sections after the confluence of the branch channels are analyzed in 30 cases in which the sheath to sample flow rate ratio Q sh /Q sam and the Reynolds number Re are varied as parameters. The results show that the decrease of the cross-sectional average ion concentration along the flow direction within the particle stream $$\overline{c}_{i}$$ c ¯ i is described by the diffusion length during the residence time with a characteristic velocity scale. In addition, the deformation of the particle stream due to inertial effects is described by a scaled Reynolds number that is a function of the flow rate ratio. The simulated particle stream thicknesses are validated by theory and a simple experiment. This paper reveals the relationship between the ion and particle concentrations and the dimensionless parameters for hydrodynamic focusing in the Y-shaped square microchannel under typical conditions.Norikazu SatoDaisuke KawashimaMasahiro TakeiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Norikazu Sato Daisuke Kawashima Masahiro Takei Concentration profiles of ions and particles under hydrodynamic focusing in Y-shaped square microchannel
description	Abstract Three-dimensional ion and particle concentrations under hydrodynamic focusing in a Y-shaped square microchannel are numerically simulated to clarify the decrease of the ion concentration along the flow direction within the focused particle stream. The simulation model is theoretically governed by the laminar flow and advection–diffusion equations. The governing equations are solved by the finite volume method. The ion and particle concentration distributions at five cross sections after the confluence of the branch channels are analyzed in 30 cases in which the sheath to sample flow rate ratio Q sh /Q sam and the Reynolds number Re are varied as parameters. The results show that the decrease of the cross-sectional average ion concentration along the flow direction within the particle stream $$\overline{c}_{i}$$ c ¯ i is described by the diffusion length during the residence time with a characteristic velocity scale. In addition, the deformation of the particle stream due to inertial effects is described by a scaled Reynolds number that is a function of the flow rate ratio. The simulated particle stream thicknesses are validated by theory and a simple experiment. This paper reveals the relationship between the ion and particle concentrations and the dimensionless parameters for hydrodynamic focusing in the Y-shaped square microchannel under typical conditions.
format	article
author	Norikazu Sato Daisuke Kawashima Masahiro Takei
author_facet	Norikazu Sato Daisuke Kawashima Masahiro Takei
author_sort	Norikazu Sato
title	Concentration profiles of ions and particles under hydrodynamic focusing in Y-shaped square microchannel
title_short	Concentration profiles of ions and particles under hydrodynamic focusing in Y-shaped square microchannel
title_full	Concentration profiles of ions and particles under hydrodynamic focusing in Y-shaped square microchannel
title_fullStr	Concentration profiles of ions and particles under hydrodynamic focusing in Y-shaped square microchannel
title_full_unstemmed	Concentration profiles of ions and particles under hydrodynamic focusing in Y-shaped square microchannel
title_sort	concentration profiles of ions and particles under hydrodynamic focusing in y-shaped square microchannel
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2d273d57c3ff43968e600571f4ca2f0d
work_keys_str_mv	AT norikazusato concentrationprofilesofionsandparticlesunderhydrodynamicfocusinginyshapedsquaremicrochannel AT daisukekawashima concentrationprofilesofionsandparticlesunderhydrodynamicfocusinginyshapedsquaremicrochannel AT masahirotakei concentrationprofilesofionsandparticlesunderhydrodynamicfocusinginyshapedsquaremicrochannel
_version_	1718393085298212864

Concentration profiles of ions and particles under hydrodynamic focusing in Y-shaped square microchannel

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