Cryo-EM structures of the TTYH family reveal a novel architecture for lipid interactions

The human Tweety homologue (TTYH) family of transmembrane proteins have been suggested to act as chloride channels. Here the authors present cryo-EM structures of the 3 human TTYH paralogs that do not display the expected features of an anion channel, and instead appear to interact with lipid-like c...

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Autores principales:	Anastasiia Sukalskaia, Monique S. Straub, Dawid Deneka, Marta Sawicka, Raimund Dutzler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2d2881505759441e904cbd1e682b44ed
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spelling	oai:doaj.org-article:2d2881505759441e904cbd1e682b44ed2021-12-02T15:07:48ZCryo-EM structures of the TTYH family reveal a novel architecture for lipid interactions10.1038/s41467-021-25106-42041-1723https://doaj.org/article/2d2881505759441e904cbd1e682b44ed2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25106-4https://doaj.org/toc/2041-1723The human Tweety homologue (TTYH) family of transmembrane proteins have been suggested to act as chloride channels. Here the authors present cryo-EM structures of the 3 human TTYH paralogs that do not display the expected features of an anion channel, and instead appear to interact with lipid-like compounds residing in the membrane; suggesting an involvement in lipid-associated processes.Anastasiia SukalskaiaMonique S. StraubDawid DenekaMarta SawickaRaimund DutzlerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anastasiia Sukalskaia Monique S. Straub Dawid Deneka Marta Sawicka Raimund Dutzler Cryo-EM structures of the TTYH family reveal a novel architecture for lipid interactions
description	The human Tweety homologue (TTYH) family of transmembrane proteins have been suggested to act as chloride channels. Here the authors present cryo-EM structures of the 3 human TTYH paralogs that do not display the expected features of an anion channel, and instead appear to interact with lipid-like compounds residing in the membrane; suggesting an involvement in lipid-associated processes.
format	article
author	Anastasiia Sukalskaia Monique S. Straub Dawid Deneka Marta Sawicka Raimund Dutzler
author_facet	Anastasiia Sukalskaia Monique S. Straub Dawid Deneka Marta Sawicka Raimund Dutzler
author_sort	Anastasiia Sukalskaia
title	Cryo-EM structures of the TTYH family reveal a novel architecture for lipid interactions
title_short	Cryo-EM structures of the TTYH family reveal a novel architecture for lipid interactions
title_full	Cryo-EM structures of the TTYH family reveal a novel architecture for lipid interactions
title_fullStr	Cryo-EM structures of the TTYH family reveal a novel architecture for lipid interactions
title_full_unstemmed	Cryo-EM structures of the TTYH family reveal a novel architecture for lipid interactions
title_sort	cryo-em structures of the ttyh family reveal a novel architecture for lipid interactions
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2d2881505759441e904cbd1e682b44ed
work_keys_str_mv	AT anastasiiasukalskaia cryoemstructuresofthettyhfamilyrevealanovelarchitectureforlipidinteractions AT moniquesstraub cryoemstructuresofthettyhfamilyrevealanovelarchitectureforlipidinteractions AT dawiddeneka cryoemstructuresofthettyhfamilyrevealanovelarchitectureforlipidinteractions AT martasawicka cryoemstructuresofthettyhfamilyrevealanovelarchitectureforlipidinteractions AT raimunddutzler cryoemstructuresofthettyhfamilyrevealanovelarchitectureforlipidinteractions
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Cryo-EM structures of the TTYH family reveal a novel architecture for lipid interactions

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