Cryo-EM structures of the TTYH family reveal a novel architecture for lipid interactions

Cryo-EM structures of the TTYH family reveal a novel architecture for lipid interactions

The human Tweety homologue (TTYH) family of transmembrane proteins have been suggested to act as chloride channels. Here the authors present cryo-EM structures of the 3 human TTYH paralogs that do not display the expected features of an anion channel, and instead appear to interact with lipid-like c...

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Autores principales: Anastasiia Sukalskaia, Monique S. Straub, Dawid Deneka, Marta Sawicka, Raimund Dutzler
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
Q
Acceso en línea:https://doaj.org/article/2d2881505759441e904cbd1e682b44ed
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