Serum hypercoagulability states in Coats’ disease

Fariba Ghassemi,1 Carol L Shields,2 Masoumeh Mohebbi,1 Mehdi Nili Ahmadabadi,1 Fatemeh Morsali,1 Siamak Sabour3,4 1Ocular Oncology and Retina and Vitreous Service, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran; 2Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferso...

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Autores principales:	Ghassemi F, Shields CL, Mohebbi M, Nili Ahmadabadi M, Morsali F, Sabour S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Anti-Cytomegalovirus Antibody Anti-herpes simplex antibody Coats Disease Blood hypercoagulability state Retinal telangiectasia Serum electrophoresis. Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/2d291ebe29ca461289c3eea2fc064a2a
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spelling	oai:doaj.org-article:2d291ebe29ca461289c3eea2fc064a2a2021-12-02T00:52:07ZSerum hypercoagulability states in Coats’ disease1177-5483https://doaj.org/article/2d291ebe29ca461289c3eea2fc064a2a2017-02-01T00:00:00Zhttps://www.dovepress.com/serum-hypercoagulability-states-in-coatsrsquo-disease-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Fariba Ghassemi,1 Carol L Shields,2 Masoumeh Mohebbi,1 Mehdi Nili Ahmadabadi,1 Fatemeh Morsali,1 Siamak Sabour3,4 1Ocular Oncology and Retina and Vitreous Service, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran; 2Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA; 3Safety Promotion and Injury Prevention Research Centre, 4Department of Clinical Epidemiology, School of Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran Purpose: The purpose of this study was to investigate the serum hypercoagulability state and common viral and protozoan infections in Coats’ disease versus a normal control group. Materials and methods: In this comparative case series, 22 consecutive patients with Coats’ disease and 19 non-Coats’ patients undergoing lensectomy for congenital, traumatic, or senile cataract between January 2011 and June 2014 were included. Laboratory data for hypercoagulability states and common viral and protozoan infections were investigated. Results: The mean age for the Coats’ group was 14.5 years (median 8 years, range: 2 months to 59 years), and for the control group it was 30.6 years (median 17 years, range: 2–82 years). In patients aged 10 years or younger, anticytomegalovirus immunoglobulin G (IgG) (P≤0.01), homocysteine (P=0.03), and serum beta globulin (P<0.001) were associated with Coats’ disease. In those older than 10 years, higher serum protein S (P=0.04), beta globulin (P=0.05), and gamma globulin (P=0.04) were related to Coats’ diagnosis. After adjusting for sex and age as confounding factors, only beta globulin was found to be associated with Coats’ disease in logistic regression analysis (odds ratio: 1.8, 95% confidence interval: 1.0–3.1, P=0.02). Conclusion: Serum beta globulin levels appear to be elevated in patients with Coats’ disease. Keywords: anti-cytomegalovirus antibody, anti-herpes simplex antibody, Coats’ disease, blood hypercoagulability state, retinal telangiectasia, serum electrophoresisGhassemi FShields CLMohebbi MNili Ahmadabadi MMorsali FSabour SDove Medical PressarticleAnti-Cytomegalovirus AntibodyAnti-herpes simplex antibodyCoats DiseaseBlood hypercoagulability stateRetinal telangiectasiaSerum electrophoresis.OphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 11, Pp 305-310 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Anti-Cytomegalovirus Antibody Anti-herpes simplex antibody Coats Disease Blood hypercoagulability state Retinal telangiectasia Serum electrophoresis. Ophthalmology RE1-994
spellingShingle	Anti-Cytomegalovirus Antibody Anti-herpes simplex antibody Coats Disease Blood hypercoagulability state Retinal telangiectasia Serum electrophoresis. Ophthalmology RE1-994 Ghassemi F Shields CL Mohebbi M Nili Ahmadabadi M Morsali F Sabour S Serum hypercoagulability states in Coats’ disease
description	Fariba Ghassemi,1 Carol L Shields,2 Masoumeh Mohebbi,1 Mehdi Nili Ahmadabadi,1 Fatemeh Morsali,1 Siamak Sabour3,4 1Ocular Oncology and Retina and Vitreous Service, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran; 2Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA; 3Safety Promotion and Injury Prevention Research Centre, 4Department of Clinical Epidemiology, School of Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran Purpose: The purpose of this study was to investigate the serum hypercoagulability state and common viral and protozoan infections in Coats’ disease versus a normal control group. Materials and methods: In this comparative case series, 22 consecutive patients with Coats’ disease and 19 non-Coats’ patients undergoing lensectomy for congenital, traumatic, or senile cataract between January 2011 and June 2014 were included. Laboratory data for hypercoagulability states and common viral and protozoan infections were investigated. Results: The mean age for the Coats’ group was 14.5 years (median 8 years, range: 2 months to 59 years), and for the control group it was 30.6 years (median 17 years, range: 2–82 years). In patients aged 10 years or younger, anticytomegalovirus immunoglobulin G (IgG) (P≤0.01), homocysteine (P=0.03), and serum beta globulin (P<0.001) were associated with Coats’ disease. In those older than 10 years, higher serum protein S (P=0.04), beta globulin (P=0.05), and gamma globulin (P=0.04) were related to Coats’ diagnosis. After adjusting for sex and age as confounding factors, only beta globulin was found to be associated with Coats’ disease in logistic regression analysis (odds ratio: 1.8, 95% confidence interval: 1.0–3.1, P=0.02). Conclusion: Serum beta globulin levels appear to be elevated in patients with Coats’ disease. Keywords: anti-cytomegalovirus antibody, anti-herpes simplex antibody, Coats’ disease, blood hypercoagulability state, retinal telangiectasia, serum electrophoresis
format	article
author	Ghassemi F Shields CL Mohebbi M Nili Ahmadabadi M Morsali F Sabour S
author_facet	Ghassemi F Shields CL Mohebbi M Nili Ahmadabadi M Morsali F Sabour S
author_sort	Ghassemi F
title	Serum hypercoagulability states in Coats’ disease
title_short	Serum hypercoagulability states in Coats’ disease
title_full	Serum hypercoagulability states in Coats’ disease
title_fullStr	Serum hypercoagulability states in Coats’ disease
title_full_unstemmed	Serum hypercoagulability states in Coats’ disease
title_sort	serum hypercoagulability states in coats’ disease
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/2d291ebe29ca461289c3eea2fc064a2a
work_keys_str_mv	AT ghassemif serumhypercoagulabilitystatesincoatsrsquodisease AT shieldscl serumhypercoagulabilitystatesincoatsrsquodisease AT mohebbim serumhypercoagulabilitystatesincoatsrsquodisease AT niliahmadabadim serumhypercoagulabilitystatesincoatsrsquodisease AT morsalif serumhypercoagulabilitystatesincoatsrsquodisease AT sabours serumhypercoagulabilitystatesincoatsrsquodisease
_version_	1718403428961484800

Serum hypercoagulability states in Coats&rsquo; disease

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