Roles of Exosomes in Cardiac Fibroblast Activation and Fibrosis

Alterations in the accumulation and composition of the extracellular matrix are part of the normal tissue repair process. During fibrosis, this process becomes dysregulated and excessive extracellular matrix alters the biomechanical properties and function of tissues involved. Historically fibrosis...

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Autores principales:	Julia Hohn, Wenbin Tan, Amanda Carver, Hayden Barrett, Wayne Carver
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	fibrosis fibroblast heart exosome Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/2d29cfa2672647e79196f3e530fb3986
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spelling	oai:doaj.org-article:2d29cfa2672647e79196f3e530fb39862021-11-25T17:09:16ZRoles of Exosomes in Cardiac Fibroblast Activation and Fibrosis10.3390/cells101129332073-4409https://doaj.org/article/2d29cfa2672647e79196f3e530fb39862021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2933https://doaj.org/toc/2073-4409Alterations in the accumulation and composition of the extracellular matrix are part of the normal tissue repair process. During fibrosis, this process becomes dysregulated and excessive extracellular matrix alters the biomechanical properties and function of tissues involved. Historically fibrosis was thought to be progressive and irreversible; however, studies suggest that fibrosis is a dynamic process whose progression can be stopped and even reversed. This realization has led to an enhanced pursuit of therapeutic agents targeting fibrosis and extracellular matrix-producing cells. In many organs, fibroblasts are the primary cells that produce the extracellular matrix. In response to diverse mechanical and biochemical stimuli, these cells are activated or transdifferentiate into specialized cells termed myofibroblasts that have an enhanced capacity to produce extracellular matrix. It is clear that interactions between diverse cells of the heart are able to modulate fibroblast activation and fibrosis. Exosomes are a form of extracellular vesicle that play an important role in intercellular communication via the cargo that they deliver to target cells. While relatively recently discovered, exosomes have been demonstrated to play important positive and negative roles in the regulation of fibroblast activation and tissue fibrosis. These roles as well as efforts to engineer exosomes as therapeutic tools will be discussed.Julia HohnWenbin TanAmanda CarverHayden BarrettWayne CarverMDPI AGarticlefibrosisfibroblastheartexosomeBiology (General)QH301-705.5ENCells, Vol 10, Iss 2933, p 2933 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	fibrosis fibroblast heart exosome Biology (General) QH301-705.5
spellingShingle	fibrosis fibroblast heart exosome Biology (General) QH301-705.5 Julia Hohn Wenbin Tan Amanda Carver Hayden Barrett Wayne Carver Roles of Exosomes in Cardiac Fibroblast Activation and Fibrosis
description	Alterations in the accumulation and composition of the extracellular matrix are part of the normal tissue repair process. During fibrosis, this process becomes dysregulated and excessive extracellular matrix alters the biomechanical properties and function of tissues involved. Historically fibrosis was thought to be progressive and irreversible; however, studies suggest that fibrosis is a dynamic process whose progression can be stopped and even reversed. This realization has led to an enhanced pursuit of therapeutic agents targeting fibrosis and extracellular matrix-producing cells. In many organs, fibroblasts are the primary cells that produce the extracellular matrix. In response to diverse mechanical and biochemical stimuli, these cells are activated or transdifferentiate into specialized cells termed myofibroblasts that have an enhanced capacity to produce extracellular matrix. It is clear that interactions between diverse cells of the heart are able to modulate fibroblast activation and fibrosis. Exosomes are a form of extracellular vesicle that play an important role in intercellular communication via the cargo that they deliver to target cells. While relatively recently discovered, exosomes have been demonstrated to play important positive and negative roles in the regulation of fibroblast activation and tissue fibrosis. These roles as well as efforts to engineer exosomes as therapeutic tools will be discussed.
format	article
author	Julia Hohn Wenbin Tan Amanda Carver Hayden Barrett Wayne Carver
author_facet	Julia Hohn Wenbin Tan Amanda Carver Hayden Barrett Wayne Carver
author_sort	Julia Hohn
title	Roles of Exosomes in Cardiac Fibroblast Activation and Fibrosis
title_short	Roles of Exosomes in Cardiac Fibroblast Activation and Fibrosis
title_full	Roles of Exosomes in Cardiac Fibroblast Activation and Fibrosis
title_fullStr	Roles of Exosomes in Cardiac Fibroblast Activation and Fibrosis
title_full_unstemmed	Roles of Exosomes in Cardiac Fibroblast Activation and Fibrosis
title_sort	roles of exosomes in cardiac fibroblast activation and fibrosis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2d29cfa2672647e79196f3e530fb3986
work_keys_str_mv	AT juliahohn rolesofexosomesincardiacfibroblastactivationandfibrosis AT wenbintan rolesofexosomesincardiacfibroblastactivationandfibrosis AT amandacarver rolesofexosomesincardiacfibroblastactivationandfibrosis AT haydenbarrett rolesofexosomesincardiacfibroblastactivationandfibrosis AT waynecarver rolesofexosomesincardiacfibroblastactivationandfibrosis
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Roles of Exosomes in Cardiac Fibroblast Activation and Fibrosis

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