Intramyocellular Lipids, Insulin Resistance, and Functional Performance in Patients with Severe Obstructive Sleep Apnea

Meng-Yueh Chien, 1–3 Pei-Lin Lee, 2–5 Chih-Wei Yu, 6 Shwu Yuan Wei, 6 Tiffany Ting-Fang Shih 6 1School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei, Taiwan; 2Center of Sleep Disorder, National Taiwan University Hospital, Ta...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Chien MY, Lee PL, Yu CW, Wei SY, Shih TTF
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	1h magnetic resonance spectroscopy insulin resistance obstructive sleep apnea skeletal muscle Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/2d2e5d1be8fb480ba0061ec90c4192bd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2d2e5d1be8fb480ba0061ec90c4192bd
record_format	dspace
institution	DOAJ
collection	DOAJ
language	EN
topic	1h magnetic resonance spectroscopy insulin resistance obstructive sleep apnea skeletal muscle Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	1h magnetic resonance spectroscopy insulin resistance obstructive sleep apnea skeletal muscle Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 Chien MY Lee PL Yu CW Wei SY Shih TTF Intramyocellular Lipids, Insulin Resistance, and Functional Performance in Patients with Severe Obstructive Sleep Apnea
description	Meng-Yueh Chien, 1–3 Pei-Lin Lee, 2–5 Chih-Wei Yu, 6 Shwu Yuan Wei, 6 Tiffany Ting-Fang Shih 6 1School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei, Taiwan; 2Center of Sleep Disorder, National Taiwan University Hospital, Taipei, Taiwan; 3Center for Obesity, Lifestyle and Metabolic Surgery, National Taiwan University Hospital, Taipei, Taiwan; 4Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; 5Center for Electronics Technology Integration, National Taiwan University, Taipei, Taiwan; 6Department of Medical Imaging and Radiology, Medical College and Hospital, National Taiwan University, Taipei, TaiwanCorrespondence: Tiffany Ting-Fang ShihDepartment of Medical Imaging and Radiology, Medical College and Hospital, National Taiwan University, No. 7, Chung Shan S. Road, Taipei 10002, TaiwanTel +886 2 23123456 ext 65568Email ttfshih@ntu.edu.twPurpose: An increasing number of studies have linked the severity of obstructive sleep apnea (OSA) with metabolic dysfunction. However, little is known about the lipid compartments (intramyocellular [IMCL] and extramyocellular [EMCL] lipids) inside the musculature in these patients. The present study was designed to investigate the IMCL and EMCL, biochemical data, and functional performance in patients with severe OSA, and to examine the correlations between intramuscular lipid contents and test variables.Participants and Methods: Twenty patients with severe OSA (apnea-hypopnea index [AHI]: ≥ 30/h; body mass index [BMI]: 26.05± 2.92) and 20 age- and BMI-matched controls (AHI < 5/h) were enrolled. Proton magnetic resonance spectroscopy was used to measure the IMCL and EMCL of the right vastus lateralis muscle. Biochemical data, including levels of fasting plasma glucose, insulin, lipid profiles, and high-sensitivity C-reactive protein (hsCRP), were measured. Insulin resistance index (IR) was calculated using the homeostasis model assessment method. Performance tests included a cardiopulmonary exercise test and knee extension strength and endurance measurements.Results: Patients with severe OSA had significantly (P< 0.05) lower values of IMCL (14.1± 5.4 AU) and EMCL (10.3± 5.8 AU) compared to the control group (25.2± 17.6 AU and 14.3± 11.1 AU, respectively). Patients with severe OSA had significantly higher hsCRP, IR, and dyslipidemia compared with controls (all P< 0.05). Furthermore, IMCL was negatively correlated with AHI, cumulative time with nocturnal pulse oximetric saturation lower than 90% (TSpO 2< 90%) (ρ=− 0.35, P< 0.05), IR (ρ=− 0.40, P< 0.05), glucose (ρ=− 0.33, P< 0.05), and insulin (ρ=− 0.36, P< 0.05), and positively correlated with lowest oximetric saturation (ρ=0.33, P< 0.01).Conclusion: Skeletal muscle dysfunction and metabolic abnormalities were observed in patients with OSA that did not have obesity. IMCL was positively correlated with aerobic capacity and muscular performance, but negatively correlated with AHI and IR. Large-scale clinical trials are required to explore the complicated mechanism among OSA, intramuscular metabolism, and insulin action.Clinical Trial Registration: ClinicalTrials.gov Identifier: NCT00813852.Keywords: 1H magnetic resonance spectroscopy, insulin resistance, obstructive sleep apnea, skeletal muscle
format	article
author	Chien MY Lee PL Yu CW Wei SY Shih TTF
author_facet	Chien MY Lee PL Yu CW Wei SY Shih TTF
author_sort	Chien MY
title	Intramyocellular Lipids, Insulin Resistance, and Functional Performance in Patients with Severe Obstructive Sleep Apnea
title_short	Intramyocellular Lipids, Insulin Resistance, and Functional Performance in Patients with Severe Obstructive Sleep Apnea
title_full	Intramyocellular Lipids, Insulin Resistance, and Functional Performance in Patients with Severe Obstructive Sleep Apnea
title_fullStr	Intramyocellular Lipids, Insulin Resistance, and Functional Performance in Patients with Severe Obstructive Sleep Apnea
title_full_unstemmed	Intramyocellular Lipids, Insulin Resistance, and Functional Performance in Patients with Severe Obstructive Sleep Apnea
title_sort	intramyocellular lipids, insulin resistance, and functional performance in patients with severe obstructive sleep apnea
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/2d2e5d1be8fb480ba0061ec90c4192bd
work_keys_str_mv	AT chienmy intramyocellularlipidsinsulinresistanceandfunctionalperformanceinpatientswithsevereobstructivesleepapnea AT leepl intramyocellularlipidsinsulinresistanceandfunctionalperformanceinpatientswithsevereobstructivesleepapnea AT yucw intramyocellularlipidsinsulinresistanceandfunctionalperformanceinpatientswithsevereobstructivesleepapnea AT weisy intramyocellularlipidsinsulinresistanceandfunctionalperformanceinpatientswithsevereobstructivesleepapnea AT shihttf intramyocellularlipidsinsulinresistanceandfunctionalperformanceinpatientswithsevereobstructivesleepapnea
_version_	1718401115182071808
spelling	oai:doaj.org-article:2d2e5d1be8fb480ba0061ec90c4192bd2021-12-02T04:34:01ZIntramyocellular Lipids, Insulin Resistance, and Functional Performance in Patients with Severe Obstructive Sleep Apnea1179-1608https://doaj.org/article/2d2e5d1be8fb480ba0061ec90c4192bd2020-01-01T00:00:00Zhttps://www.dovepress.com/intramyocellular-lipids-insulin-resistance-and-functional-performance--peer-reviewed-article-NSShttps://doaj.org/toc/1179-1608Meng-Yueh Chien, 1–3 Pei-Lin Lee, 2–5 Chih-Wei Yu, 6 Shwu Yuan Wei, 6 Tiffany Ting-Fang Shih 6 1School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei, Taiwan; 2Center of Sleep Disorder, National Taiwan University Hospital, Taipei, Taiwan; 3Center for Obesity, Lifestyle and Metabolic Surgery, National Taiwan University Hospital, Taipei, Taiwan; 4Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; 5Center for Electronics Technology Integration, National Taiwan University, Taipei, Taiwan; 6Department of Medical Imaging and Radiology, Medical College and Hospital, National Taiwan University, Taipei, TaiwanCorrespondence: Tiffany Ting-Fang ShihDepartment of Medical Imaging and Radiology, Medical College and Hospital, National Taiwan University, No. 7, Chung Shan S. Road, Taipei 10002, TaiwanTel +886 2 23123456 ext 65568Email ttfshih@ntu.edu.twPurpose: An increasing number of studies have linked the severity of obstructive sleep apnea (OSA) with metabolic dysfunction. However, little is known about the lipid compartments (intramyocellular [IMCL] and extramyocellular [EMCL] lipids) inside the musculature in these patients. The present study was designed to investigate the IMCL and EMCL, biochemical data, and functional performance in patients with severe OSA, and to examine the correlations between intramuscular lipid contents and test variables.Participants and Methods: Twenty patients with severe OSA (apnea-hypopnea index [AHI]: ≥ 30/h; body mass index [BMI]: 26.05± 2.92) and 20 age- and BMI-matched controls (AHI < 5/h) were enrolled. Proton magnetic resonance spectroscopy was used to measure the IMCL and EMCL of the right vastus lateralis muscle. Biochemical data, including levels of fasting plasma glucose, insulin, lipid profiles, and high-sensitivity C-reactive protein (hsCRP), were measured. Insulin resistance index (IR) was calculated using the homeostasis model assessment method. Performance tests included a cardiopulmonary exercise test and knee extension strength and endurance measurements.Results: Patients with severe OSA had significantly (P< 0.05) lower values of IMCL (14.1± 5.4 AU) and EMCL (10.3± 5.8 AU) compared to the control group (25.2± 17.6 AU and 14.3± 11.1 AU, respectively). Patients with severe OSA had significantly higher hsCRP, IR, and dyslipidemia compared with controls (all P< 0.05). Furthermore, IMCL was negatively correlated with AHI, cumulative time with nocturnal pulse oximetric saturation lower than 90% (TSpO 2< 90%) (ρ=− 0.35, P< 0.05), IR (ρ=− 0.40, P< 0.05), glucose (ρ=− 0.33, P< 0.05), and insulin (ρ=− 0.36, P< 0.05), and positively correlated with lowest oximetric saturation (ρ=0.33, P< 0.01).Conclusion: Skeletal muscle dysfunction and metabolic abnormalities were observed in patients with OSA that did not have obesity. IMCL was positively correlated with aerobic capacity and muscular performance, but negatively correlated with AHI and IR. Large-scale clinical trials are required to explore the complicated mechanism among OSA, intramuscular metabolism, and insulin action.Clinical Trial Registration: ClinicalTrials.gov Identifier: NCT00813852.Keywords: 1H magnetic resonance spectroscopy, insulin resistance, obstructive sleep apnea, skeletal muscleChien MYLee PLYu CWWei SYShih TTFDove Medical Pressarticle1h magnetic resonance spectroscopyinsulin resistanceobstructive sleep apneaskeletal musclePsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol Volume 12, Pp 69-78 (2020)

Intramyocellular Lipids, Insulin Resistance, and Functional Performance in Patients with Severe Obstructive Sleep Apnea

Ejemplares similares