Bringing biocatalytic deuteration into the toolbox of asymmetric isotopic labelling techniques

Deuterated chemicals are widely exploited in analytical chemistry and increasingly in the synthesis of pharmaceutical compounds. Here, the authors developed a mild biocatalytic method for the selective asymmetric reductive deuteration of organic compounds, by using H2 and 2H2O to generate 2H-NADH....

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Autores principales:	J. S. Rowbotham, M. A. Ramirez, O. Lenz, H. A. Reeve, K. A. Vincent
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2d3006b0e3ac453589d1a5b6bb9c396e
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spelling	oai:doaj.org-article:2d3006b0e3ac453589d1a5b6bb9c396e2021-12-02T14:40:29ZBringing biocatalytic deuteration into the toolbox of asymmetric isotopic labelling techniques10.1038/s41467-020-15310-z2041-1723https://doaj.org/article/2d3006b0e3ac453589d1a5b6bb9c396e2020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15310-zhttps://doaj.org/toc/2041-1723Deuterated chemicals are widely exploited in analytical chemistry and increasingly in the synthesis of pharmaceutical compounds. Here, the authors developed a mild biocatalytic method for the selective asymmetric reductive deuteration of organic compounds, by using H2 and 2H2O to generate 2H-NADH.J. S. RowbothamM. A. RamirezO. LenzH. A. ReeveK. A. VincentNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q J. S. Rowbotham M. A. Ramirez O. Lenz H. A. Reeve K. A. Vincent Bringing biocatalytic deuteration into the toolbox of asymmetric isotopic labelling techniques
description	Deuterated chemicals are widely exploited in analytical chemistry and increasingly in the synthesis of pharmaceutical compounds. Here, the authors developed a mild biocatalytic method for the selective asymmetric reductive deuteration of organic compounds, by using H2 and 2H2O to generate 2H-NADH.
format	article
author	J. S. Rowbotham M. A. Ramirez O. Lenz H. A. Reeve K. A. Vincent
author_facet	J. S. Rowbotham M. A. Ramirez O. Lenz H. A. Reeve K. A. Vincent
author_sort	J. S. Rowbotham
title	Bringing biocatalytic deuteration into the toolbox of asymmetric isotopic labelling techniques
title_short	Bringing biocatalytic deuteration into the toolbox of asymmetric isotopic labelling techniques
title_full	Bringing biocatalytic deuteration into the toolbox of asymmetric isotopic labelling techniques
title_fullStr	Bringing biocatalytic deuteration into the toolbox of asymmetric isotopic labelling techniques
title_full_unstemmed	Bringing biocatalytic deuteration into the toolbox of asymmetric isotopic labelling techniques
title_sort	bringing biocatalytic deuteration into the toolbox of asymmetric isotopic labelling techniques
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/2d3006b0e3ac453589d1a5b6bb9c396e
work_keys_str_mv	AT jsrowbotham bringingbiocatalyticdeuterationintothetoolboxofasymmetricisotopiclabellingtechniques AT maramirez bringingbiocatalyticdeuterationintothetoolboxofasymmetricisotopiclabellingtechniques AT olenz bringingbiocatalyticdeuterationintothetoolboxofasymmetricisotopiclabellingtechniques AT hareeve bringingbiocatalyticdeuterationintothetoolboxofasymmetricisotopiclabellingtechniques AT kavincent bringingbiocatalyticdeuterationintothetoolboxofasymmetricisotopiclabellingtechniques
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Bringing biocatalytic deuteration into the toolbox of asymmetric isotopic labelling techniques

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