Anti-SARS-CoV-2 Spike Protein RBD Antibody Levels After Receiving a Second Dose of ChAdOx1 nCov-19 (AZD1222) Vaccine in Healthcare Workers: Lack of Association With Age, Sex, Obesity, and Adverse Reactions

Response to vaccines generally varies according to individual factors of the vaccinated subjects such as demographics and immune status. While there are various reports of factors associated with immunogenicity of mRNA COVID-19 vaccines, little is known about those of adenovirus vector vaccines. We...

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Autores principales:	Sang Won Lee, Ji-Yong Moon, Sun-Kyung Lee, Hyun Lee, SeolHwa Moon, Sung Jun Chung, Yoomi Yeo, Tai Sun Park, Dong Won Park, Tae-Hyung Kim, Jang Won Sohn, Ho Joo Yoon, Sang-Heon Kim
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	COVID-19 vaccine antibody adverse reaction age sex Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/2d31818c17c94ad3b1957d1dde88335f
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spelling	oai:doaj.org-article:2d31818c17c94ad3b1957d1dde88335f2021-11-30T21:13:25ZAnti-SARS-CoV-2 Spike Protein RBD Antibody Levels After Receiving a Second Dose of ChAdOx1 nCov-19 (AZD1222) Vaccine in Healthcare Workers: Lack of Association With Age, Sex, Obesity, and Adverse Reactions1664-322410.3389/fimmu.2021.779212https://doaj.org/article/2d31818c17c94ad3b1957d1dde88335f2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.779212/fullhttps://doaj.org/toc/1664-3224Response to vaccines generally varies according to individual factors of the vaccinated subjects such as demographics and immune status. While there are various reports of factors associated with immunogenicity of mRNA COVID-19 vaccines, little is known about those of adenovirus vector vaccines. We conducted a prospective observational study to assess the relationships of antibody level with age, sex, body mass index (BMI), and adverse reactions (ARs) to an adenovirus vector vaccine, ChAdOx1 nCoV-19. Healthcare workers who planned to receive both the first and second injections of the ChAdOx1 nCoV-19 vaccine at Hanyang University Hospital, Seoul, Korea, were enrolled in the study. Seven days after each injection, participants were asked to complete an online adverse reaction survey. In addition, anti-SARS-CoV-2 spike (S) protein receptor binding domain (RBD) antibody concentration was measured 4 weeks after the second injection. All participants (n = 447, 100%) showed serologic positivity (≥ 0.8 U/mL) 4 weeks after the second injection of ChAdOx1 nCoV-19 vaccine. Furthermore, the anti-SARS-CoV-2 S protein RBD concentration was similar among groups when stratified by age, sex, BMI, or presence and severity of AR; multivariable linear regression found no associations between antibody response to the ChAdOx1 nCoV-19 vaccine and age, BMI, sex, and vaccine-induced ARs. In conclusion, age, sex, obesity, and ARs were not associated with antibody responses after two doses of ChAdOx1 nCoV-19 vaccination.Sang Won LeeJi-Yong MoonSun-Kyung LeeSun-Kyung LeeHyun LeeSeolHwa MoonSung Jun ChungYoomi YeoTai Sun ParkDong Won ParkTae-Hyung KimJang Won SohnHo Joo YoonSang-Heon KimFrontiers Media S.A.articleCOVID-19vaccineantibodyadverse reactionagesexImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 vaccine antibody adverse reaction age sex Immunologic diseases. Allergy RC581-607
spellingShingle	COVID-19 vaccine antibody adverse reaction age sex Immunologic diseases. Allergy RC581-607 Sang Won Lee Ji-Yong Moon Sun-Kyung Lee Sun-Kyung Lee Hyun Lee SeolHwa Moon Sung Jun Chung Yoomi Yeo Tai Sun Park Dong Won Park Tae-Hyung Kim Jang Won Sohn Ho Joo Yoon Sang-Heon Kim Anti-SARS-CoV-2 Spike Protein RBD Antibody Levels After Receiving a Second Dose of ChAdOx1 nCov-19 (AZD1222) Vaccine in Healthcare Workers: Lack of Association With Age, Sex, Obesity, and Adverse Reactions
description	Response to vaccines generally varies according to individual factors of the vaccinated subjects such as demographics and immune status. While there are various reports of factors associated with immunogenicity of mRNA COVID-19 vaccines, little is known about those of adenovirus vector vaccines. We conducted a prospective observational study to assess the relationships of antibody level with age, sex, body mass index (BMI), and adverse reactions (ARs) to an adenovirus vector vaccine, ChAdOx1 nCoV-19. Healthcare workers who planned to receive both the first and second injections of the ChAdOx1 nCoV-19 vaccine at Hanyang University Hospital, Seoul, Korea, were enrolled in the study. Seven days after each injection, participants were asked to complete an online adverse reaction survey. In addition, anti-SARS-CoV-2 spike (S) protein receptor binding domain (RBD) antibody concentration was measured 4 weeks after the second injection. All participants (n = 447, 100%) showed serologic positivity (≥ 0.8 U/mL) 4 weeks after the second injection of ChAdOx1 nCoV-19 vaccine. Furthermore, the anti-SARS-CoV-2 S protein RBD concentration was similar among groups when stratified by age, sex, BMI, or presence and severity of AR; multivariable linear regression found no associations between antibody response to the ChAdOx1 nCoV-19 vaccine and age, BMI, sex, and vaccine-induced ARs. In conclusion, age, sex, obesity, and ARs were not associated with antibody responses after two doses of ChAdOx1 nCoV-19 vaccination.
format	article
author	Sang Won Lee Ji-Yong Moon Sun-Kyung Lee Sun-Kyung Lee Hyun Lee SeolHwa Moon Sung Jun Chung Yoomi Yeo Tai Sun Park Dong Won Park Tae-Hyung Kim Jang Won Sohn Ho Joo Yoon Sang-Heon Kim
author_facet	Sang Won Lee Ji-Yong Moon Sun-Kyung Lee Sun-Kyung Lee Hyun Lee SeolHwa Moon Sung Jun Chung Yoomi Yeo Tai Sun Park Dong Won Park Tae-Hyung Kim Jang Won Sohn Ho Joo Yoon Sang-Heon Kim
author_sort	Sang Won Lee
title	Anti-SARS-CoV-2 Spike Protein RBD Antibody Levels After Receiving a Second Dose of ChAdOx1 nCov-19 (AZD1222) Vaccine in Healthcare Workers: Lack of Association With Age, Sex, Obesity, and Adverse Reactions
title_short	Anti-SARS-CoV-2 Spike Protein RBD Antibody Levels After Receiving a Second Dose of ChAdOx1 nCov-19 (AZD1222) Vaccine in Healthcare Workers: Lack of Association With Age, Sex, Obesity, and Adverse Reactions
title_full	Anti-SARS-CoV-2 Spike Protein RBD Antibody Levels After Receiving a Second Dose of ChAdOx1 nCov-19 (AZD1222) Vaccine in Healthcare Workers: Lack of Association With Age, Sex, Obesity, and Adverse Reactions
title_fullStr	Anti-SARS-CoV-2 Spike Protein RBD Antibody Levels After Receiving a Second Dose of ChAdOx1 nCov-19 (AZD1222) Vaccine in Healthcare Workers: Lack of Association With Age, Sex, Obesity, and Adverse Reactions
title_full_unstemmed	Anti-SARS-CoV-2 Spike Protein RBD Antibody Levels After Receiving a Second Dose of ChAdOx1 nCov-19 (AZD1222) Vaccine in Healthcare Workers: Lack of Association With Age, Sex, Obesity, and Adverse Reactions
title_sort	anti-sars-cov-2 spike protein rbd antibody levels after receiving a second dose of chadox1 ncov-19 (azd1222) vaccine in healthcare workers: lack of association with age, sex, obesity, and adverse reactions
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/2d31818c17c94ad3b1957d1dde88335f
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Anti-SARS-CoV-2 Spike Protein RBD Antibody Levels After Receiving a Second Dose of ChAdOx1 nCov-19 (AZD1222) Vaccine in Healthcare Workers: Lack of Association With Age, Sex, Obesity, and Adverse Reactions

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