Pathophysiology and pathological findings of heatstroke in dogs

Mariarita Romanucci, Leonardo Della SaldaDepartment of Comparative Biomedical Sciences, Faculty of Veterinary Medicine, University of Teramo, Teramo, ItalyAbstract: Canine heatstroke is a life-threatening condition resulting from an imbalance between heat dissipation and production, and characterize...

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Autores principales:	Romanucci M, Della Salda L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/2d3265d33ffa425a93f4d1928e1e5752
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spelling	oai:doaj.org-article:2d3265d33ffa425a93f4d1928e1e57522021-12-02T00:33:55ZPathophysiology and pathological findings of heatstroke in dogs2230-2034https://doaj.org/article/2d3265d33ffa425a93f4d1928e1e57522013-01-01T00:00:00Zhttp://www.dovepress.com/pathophysiology-and-pathological-findings-of-heatstroke-in-dogs-a11910https://doaj.org/toc/2230-2034Mariarita Romanucci, Leonardo Della SaldaDepartment of Comparative Biomedical Sciences, Faculty of Veterinary Medicine, University of Teramo, Teramo, ItalyAbstract: Canine heatstroke is a life-threatening condition resulting from an imbalance between heat dissipation and production, and characterized by a nonpyrogenic elevation in core body temperature above 41&deg;C (105.8&deg;F). Several exogenous and endogenous factors may predispose dogs to the development of heatstroke; on the other hand, adaptive mechanisms also exists which allow organisms to combat the deleterious effects of heat stress, which are represented by the cellular heat-shock response and heat acclimatization. The pathophysiology and consequences of heatstroke share many similarities to those observable in sepsis and are related to the interaction between the direct cytotoxicity of heat, the acute physiological alterations associated with hyperthermia, such as increased metabolic demand, hypoxia, and circulatory failure, and the inflammatory and coagulation responses of the host to the widespread endothelial and tissue injuries, which may culminate in disseminated intravascular coagulation, systemic inflammatory response syndrome, and multiple organ dysfunction.Keywords: thermoregulation, acclimatization, heat shock proteins, hyperthermia, systemic inflammatory response, multiple organ dysfunctionRomanucci MDella Salda LDove Medical PressarticleVeterinary medicineSF600-1100ENVeterinary Medicine: Research and Reports, Vol 2013, Iss default, Pp 1-9 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Veterinary medicine SF600-1100
spellingShingle	Veterinary medicine SF600-1100 Romanucci M Della Salda L Pathophysiology and pathological findings of heatstroke in dogs
description	Mariarita Romanucci, Leonardo Della SaldaDepartment of Comparative Biomedical Sciences, Faculty of Veterinary Medicine, University of Teramo, Teramo, ItalyAbstract: Canine heatstroke is a life-threatening condition resulting from an imbalance between heat dissipation and production, and characterized by a nonpyrogenic elevation in core body temperature above 41&deg;C (105.8&deg;F). Several exogenous and endogenous factors may predispose dogs to the development of heatstroke; on the other hand, adaptive mechanisms also exists which allow organisms to combat the deleterious effects of heat stress, which are represented by the cellular heat-shock response and heat acclimatization. The pathophysiology and consequences of heatstroke share many similarities to those observable in sepsis and are related to the interaction between the direct cytotoxicity of heat, the acute physiological alterations associated with hyperthermia, such as increased metabolic demand, hypoxia, and circulatory failure, and the inflammatory and coagulation responses of the host to the widespread endothelial and tissue injuries, which may culminate in disseminated intravascular coagulation, systemic inflammatory response syndrome, and multiple organ dysfunction.Keywords: thermoregulation, acclimatization, heat shock proteins, hyperthermia, systemic inflammatory response, multiple organ dysfunction
format	article
author	Romanucci M Della Salda L
author_facet	Romanucci M Della Salda L
author_sort	Romanucci M
title	Pathophysiology and pathological findings of heatstroke in dogs
title_short	Pathophysiology and pathological findings of heatstroke in dogs
title_full	Pathophysiology and pathological findings of heatstroke in dogs
title_fullStr	Pathophysiology and pathological findings of heatstroke in dogs
title_full_unstemmed	Pathophysiology and pathological findings of heatstroke in dogs
title_sort	pathophysiology and pathological findings of heatstroke in dogs
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/2d3265d33ffa425a93f4d1928e1e5752
work_keys_str_mv	AT romanuccim pathophysiologyandpathologicalfindingsofheatstrokeindogs AT dellasaldal pathophysiologyandpathologicalfindingsofheatstrokeindogs
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Pathophysiology and pathological findings of heatstroke in dogs

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