Anti-inflammatory action of astaxanthin and its use in the treatment of various diseases

Astaxanthin (AST) is a red pigmented carotenoid with significant antioxidant, anti-inflammatory, anti-proliferative, and anti-apoptotic properties. In this study, we summarize the available literature on the anti-inflammatory efficacy of AST in various chronic and acute disorders, such as neurodegen...

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Autores principales:	Zeynab Kohandel, Tahereh Farkhondeh, Michael Aschner, Ali Mohammad Pourbagher-Shahri, Saeed Samarghandian
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Astaxanthin E-astaxanthin Inflammation Oxidative stress Apoptosis Proliferation Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/2d326844b2e74fdf99c68a08c1aacf86
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spelling	oai:doaj.org-article:2d326844b2e74fdf99c68a08c1aacf862021-11-04T04:26:09ZAnti-inflammatory action of astaxanthin and its use in the treatment of various diseases0753-332210.1016/j.biopha.2021.112179https://doaj.org/article/2d326844b2e74fdf99c68a08c1aacf862022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S075333222100963Xhttps://doaj.org/toc/0753-3322Astaxanthin (AST) is a red pigmented carotenoid with significant antioxidant, anti-inflammatory, anti-proliferative, and anti-apoptotic properties. In this study, we summarize the available literature on the anti-inflammatory efficacy of AST in various chronic and acute disorders, such as neurodegenerative, renal-, hepato-, skin- and eye-related diseases, as well as gastrointestinal disorders. In addition, we elaborated on therapeutic efficacy of AST and the role of several pathways, including PI3K/AKT, Nrf2, NF-κB, ERK1/2, JNK, p38 MAPK, and JAK-2/STAT-3 in mediating its effects. However, additional experimental and clinical studies should be performed to corroborate the anti-inflammatory effects and protective effects of AST against inflammatory diseases in humans. Nevertheless, this review suggests that AST with its demonstrated anti-inflammatory property may be a suitable candidate for drug design with novel technology.Zeynab KohandelTahereh FarkhondehMichael AschnerAli Mohammad Pourbagher-ShahriSaeed SamarghandianElsevierarticleAstaxanthinE-astaxanthinInflammationOxidative stressApoptosisProliferationTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 145, Iss , Pp 112179- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Astaxanthin E-astaxanthin Inflammation Oxidative stress Apoptosis Proliferation Therapeutics. Pharmacology RM1-950
spellingShingle	Astaxanthin E-astaxanthin Inflammation Oxidative stress Apoptosis Proliferation Therapeutics. Pharmacology RM1-950 Zeynab Kohandel Tahereh Farkhondeh Michael Aschner Ali Mohammad Pourbagher-Shahri Saeed Samarghandian Anti-inflammatory action of astaxanthin and its use in the treatment of various diseases
description	Astaxanthin (AST) is a red pigmented carotenoid with significant antioxidant, anti-inflammatory, anti-proliferative, and anti-apoptotic properties. In this study, we summarize the available literature on the anti-inflammatory efficacy of AST in various chronic and acute disorders, such as neurodegenerative, renal-, hepato-, skin- and eye-related diseases, as well as gastrointestinal disorders. In addition, we elaborated on therapeutic efficacy of AST and the role of several pathways, including PI3K/AKT, Nrf2, NF-κB, ERK1/2, JNK, p38 MAPK, and JAK-2/STAT-3 in mediating its effects. However, additional experimental and clinical studies should be performed to corroborate the anti-inflammatory effects and protective effects of AST against inflammatory diseases in humans. Nevertheless, this review suggests that AST with its demonstrated anti-inflammatory property may be a suitable candidate for drug design with novel technology.
format	article
author	Zeynab Kohandel Tahereh Farkhondeh Michael Aschner Ali Mohammad Pourbagher-Shahri Saeed Samarghandian
author_facet	Zeynab Kohandel Tahereh Farkhondeh Michael Aschner Ali Mohammad Pourbagher-Shahri Saeed Samarghandian
author_sort	Zeynab Kohandel
title	Anti-inflammatory action of astaxanthin and its use in the treatment of various diseases
title_short	Anti-inflammatory action of astaxanthin and its use in the treatment of various diseases
title_full	Anti-inflammatory action of astaxanthin and its use in the treatment of various diseases
title_fullStr	Anti-inflammatory action of astaxanthin and its use in the treatment of various diseases
title_full_unstemmed	Anti-inflammatory action of astaxanthin and its use in the treatment of various diseases
title_sort	anti-inflammatory action of astaxanthin and its use in the treatment of various diseases
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/2d326844b2e74fdf99c68a08c1aacf86
work_keys_str_mv	AT zeynabkohandel antiinflammatoryactionofastaxanthinanditsuseinthetreatmentofvariousdiseases AT taherehfarkhondeh antiinflammatoryactionofastaxanthinanditsuseinthetreatmentofvariousdiseases AT michaelaschner antiinflammatoryactionofastaxanthinanditsuseinthetreatmentofvariousdiseases AT alimohammadpourbaghershahri antiinflammatoryactionofastaxanthinanditsuseinthetreatmentofvariousdiseases AT saeedsamarghandian antiinflammatoryactionofastaxanthinanditsuseinthetreatmentofvariousdiseases
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Anti-inflammatory action of astaxanthin and its use in the treatment of various diseases

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