Generation of TALEN-mediated GRdim knock-in rats by homologous recombination.

Generation of TALEN-mediated GRdim knock-in rats by homologous recombination.

Transcription Activator-Like Effector Nucleases (TALEN) are potential tools for precise genome engineering of laboratory animals. We report the first targeted genomic integration in the rat using TALENs (Transcription Activator-Like Effector Nucleases) by homology-derived recombination (HDR). We ass...

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Autores principales: Verónica Ponce de León, Anne-Marie Mérillat, Laurent Tesson, Ignacio Anegón, Edith Hummler
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/2d32fd8d3b0f4b059d6202bbf313b382
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