The admixture structure and genetic variation of the archipelago of Cape Verde and its implications for admixture mapping studies.
Recently admixed populations offer unique opportunities for studying human history and for elucidating the genetic basis of complex traits that differ in prevalence between human populations. Historical records, classical protein markers, and preliminary genetic data indicate that the Cape Verde isl...
Guardado en:
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2012
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/2d38b493f1314f9298560e91c69e3530 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:2d38b493f1314f9298560e91c69e3530 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:2d38b493f1314f9298560e91c69e35302021-11-18T08:06:34ZThe admixture structure and genetic variation of the archipelago of Cape Verde and its implications for admixture mapping studies.1932-620310.1371/journal.pone.0051103https://doaj.org/article/2d38b493f1314f9298560e91c69e35302012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23226471/?tool=EBIhttps://doaj.org/toc/1932-6203Recently admixed populations offer unique opportunities for studying human history and for elucidating the genetic basis of complex traits that differ in prevalence between human populations. Historical records, classical protein markers, and preliminary genetic data indicate that the Cape Verde islands in West Africa are highly admixed and primarily descended from European males and African females. However, little is known about the variation in admixture levels, admixture dynamics and genetic diversity across the islands, or about the potential of Cape Verde for admixture mapping studies. We have performed a detailed analysis of phenotypic and genetic variation in Cape Verde based on objective skin color measurements, socio-economic status (SES) evaluations and data for 50 autosomal, 34 X-chromosome, and 21 non-recombinant Y-chromosome (NRY) markers in 845 individuals from six islands of the archipelago. We find extensive genetic admixture between European and African ancestral populations (mean West African ancestry = 0.57, sd = 0.08), with individual African ancestry proportions varying considerably among the islands. African ancestry proportions calculated with X and Y-chromosome markers confirm that the pattern of admixture has been sex-biased. The high-resolution NRY-STRs reveal additional patterns of variation among the islands that are most consistent with differentiation after admixture. The differences in the autosomal admixture proportions are clearly evident in the skin color distribution across the islands (Pearson r = 0.54, P-value<2e-16). Despite this strong correlation, there are significant interactions between SES and skin color that are independent of the relationship between skin color and genetic ancestry. The observed distributions of admixture, genetic variation and skin color and the relationship of skin color with SES relate to historical and social events taking place during the settlement history of Cape Verde, and have implications for the design of association studies using this population.Sandra BelezaJoana CamposJailson LopesIsabel Inês AraújoAna Hoppfer AlmadaAntónio Correia e SilvaEsteban J ParraJorge RochaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e51103 (2012) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Sandra Beleza Joana Campos Jailson Lopes Isabel Inês Araújo Ana Hoppfer Almada António Correia e Silva Esteban J Parra Jorge Rocha The admixture structure and genetic variation of the archipelago of Cape Verde and its implications for admixture mapping studies. |
| description |
Recently admixed populations offer unique opportunities for studying human history and for elucidating the genetic basis of complex traits that differ in prevalence between human populations. Historical records, classical protein markers, and preliminary genetic data indicate that the Cape Verde islands in West Africa are highly admixed and primarily descended from European males and African females. However, little is known about the variation in admixture levels, admixture dynamics and genetic diversity across the islands, or about the potential of Cape Verde for admixture mapping studies. We have performed a detailed analysis of phenotypic and genetic variation in Cape Verde based on objective skin color measurements, socio-economic status (SES) evaluations and data for 50 autosomal, 34 X-chromosome, and 21 non-recombinant Y-chromosome (NRY) markers in 845 individuals from six islands of the archipelago. We find extensive genetic admixture between European and African ancestral populations (mean West African ancestry = 0.57, sd = 0.08), with individual African ancestry proportions varying considerably among the islands. African ancestry proportions calculated with X and Y-chromosome markers confirm that the pattern of admixture has been sex-biased. The high-resolution NRY-STRs reveal additional patterns of variation among the islands that are most consistent with differentiation after admixture. The differences in the autosomal admixture proportions are clearly evident in the skin color distribution across the islands (Pearson r = 0.54, P-value<2e-16). Despite this strong correlation, there are significant interactions between SES and skin color that are independent of the relationship between skin color and genetic ancestry. The observed distributions of admixture, genetic variation and skin color and the relationship of skin color with SES relate to historical and social events taking place during the settlement history of Cape Verde, and have implications for the design of association studies using this population. |
| format |
article |
| author |
Sandra Beleza Joana Campos Jailson Lopes Isabel Inês Araújo Ana Hoppfer Almada António Correia e Silva Esteban J Parra Jorge Rocha |
| author_facet |
Sandra Beleza Joana Campos Jailson Lopes Isabel Inês Araújo Ana Hoppfer Almada António Correia e Silva Esteban J Parra Jorge Rocha |
| author_sort |
Sandra Beleza |
| title |
The admixture structure and genetic variation of the archipelago of Cape Verde and its implications for admixture mapping studies. |
| title_short |
The admixture structure and genetic variation of the archipelago of Cape Verde and its implications for admixture mapping studies. |
| title_full |
The admixture structure and genetic variation of the archipelago of Cape Verde and its implications for admixture mapping studies. |
| title_fullStr |
The admixture structure and genetic variation of the archipelago of Cape Verde and its implications for admixture mapping studies. |
| title_full_unstemmed |
The admixture structure and genetic variation of the archipelago of Cape Verde and its implications for admixture mapping studies. |
| title_sort |
admixture structure and genetic variation of the archipelago of cape verde and its implications for admixture mapping studies. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2012 |
| url |
https://doaj.org/article/2d38b493f1314f9298560e91c69e3530 |
| work_keys_str_mv |
AT sandrabeleza theadmixturestructureandgeneticvariationofthearchipelagoofcapeverdeanditsimplicationsforadmixturemappingstudies AT joanacampos theadmixturestructureandgeneticvariationofthearchipelagoofcapeverdeanditsimplicationsforadmixturemappingstudies AT jailsonlopes theadmixturestructureandgeneticvariationofthearchipelagoofcapeverdeanditsimplicationsforadmixturemappingstudies AT isabelinesaraujo theadmixturestructureandgeneticvariationofthearchipelagoofcapeverdeanditsimplicationsforadmixturemappingstudies AT anahoppferalmada theadmixturestructureandgeneticvariationofthearchipelagoofcapeverdeanditsimplicationsforadmixturemappingstudies AT antoniocorreiaesilva theadmixturestructureandgeneticvariationofthearchipelagoofcapeverdeanditsimplicationsforadmixturemappingstudies AT estebanjparra theadmixturestructureandgeneticvariationofthearchipelagoofcapeverdeanditsimplicationsforadmixturemappingstudies AT jorgerocha theadmixturestructureandgeneticvariationofthearchipelagoofcapeverdeanditsimplicationsforadmixturemappingstudies AT sandrabeleza admixturestructureandgeneticvariationofthearchipelagoofcapeverdeanditsimplicationsforadmixturemappingstudies AT joanacampos admixturestructureandgeneticvariationofthearchipelagoofcapeverdeanditsimplicationsforadmixturemappingstudies AT jailsonlopes admixturestructureandgeneticvariationofthearchipelagoofcapeverdeanditsimplicationsforadmixturemappingstudies AT isabelinesaraujo admixturestructureandgeneticvariationofthearchipelagoofcapeverdeanditsimplicationsforadmixturemappingstudies AT anahoppferalmada admixturestructureandgeneticvariationofthearchipelagoofcapeverdeanditsimplicationsforadmixturemappingstudies AT antoniocorreiaesilva admixturestructureandgeneticvariationofthearchipelagoofcapeverdeanditsimplicationsforadmixturemappingstudies AT estebanjparra admixturestructureandgeneticvariationofthearchipelagoofcapeverdeanditsimplicationsforadmixturemappingstudies AT jorgerocha admixturestructureandgeneticvariationofthearchipelagoofcapeverdeanditsimplicationsforadmixturemappingstudies |
| _version_ |
1718422218881368064 |