TSPAN15 interacts with BTRC to promote oesophageal squamous cell carcinoma metastasis via activating NF-κB signaling

BTRC can activate NF-κB signaling through the ubiquitination and degradation of IκB-α. Here the authors show that TSPAN15 promotes metastasis of oesophageal squamous cell cancer by enhancing BTRC induced degradation of IκB-α and subsequent activation of NF-κB.

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Autores principales:	Baozhu Zhang, Zhao Zhang, Lei Li, Yan-Ru Qin, Haibo Liu, Chen Jiang, Ting-Ting Zeng, Meng-Qing Li, Dan Xie, Yan Li, Xin-Yuan Guan, Ying-Hui Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2d3e5f6cc5824d78aea4b2ad946071fd
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spelling	oai:doaj.org-article:2d3e5f6cc5824d78aea4b2ad946071fd2021-12-02T15:33:59ZTSPAN15 interacts with BTRC to promote oesophageal squamous cell carcinoma metastasis via activating NF-κB signaling10.1038/s41467-018-03716-92041-1723https://doaj.org/article/2d3e5f6cc5824d78aea4b2ad946071fd2018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03716-9https://doaj.org/toc/2041-1723BTRC can activate NF-κB signaling through the ubiquitination and degradation of IκB-α. Here the authors show that TSPAN15 promotes metastasis of oesophageal squamous cell cancer by enhancing BTRC induced degradation of IκB-α and subsequent activation of NF-κB.Baozhu ZhangZhao ZhangLei LiYan-Ru QinHaibo LiuChen JiangTing-Ting ZengMeng-Qing LiDan XieYan LiXin-Yuan GuanYing-Hui ZhuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Baozhu Zhang Zhao Zhang Lei Li Yan-Ru Qin Haibo Liu Chen Jiang Ting-Ting Zeng Meng-Qing Li Dan Xie Yan Li Xin-Yuan Guan Ying-Hui Zhu TSPAN15 interacts with BTRC to promote oesophageal squamous cell carcinoma metastasis via activating NF-κB signaling
description	BTRC can activate NF-κB signaling through the ubiquitination and degradation of IκB-α. Here the authors show that TSPAN15 promotes metastasis of oesophageal squamous cell cancer by enhancing BTRC induced degradation of IκB-α and subsequent activation of NF-κB.
format	article
author	Baozhu Zhang Zhao Zhang Lei Li Yan-Ru Qin Haibo Liu Chen Jiang Ting-Ting Zeng Meng-Qing Li Dan Xie Yan Li Xin-Yuan Guan Ying-Hui Zhu
author_facet	Baozhu Zhang Zhao Zhang Lei Li Yan-Ru Qin Haibo Liu Chen Jiang Ting-Ting Zeng Meng-Qing Li Dan Xie Yan Li Xin-Yuan Guan Ying-Hui Zhu
author_sort	Baozhu Zhang
title	TSPAN15 interacts with BTRC to promote oesophageal squamous cell carcinoma metastasis via activating NF-κB signaling
title_short	TSPAN15 interacts with BTRC to promote oesophageal squamous cell carcinoma metastasis via activating NF-κB signaling
title_full	TSPAN15 interacts with BTRC to promote oesophageal squamous cell carcinoma metastasis via activating NF-κB signaling
title_fullStr	TSPAN15 interacts with BTRC to promote oesophageal squamous cell carcinoma metastasis via activating NF-κB signaling
title_full_unstemmed	TSPAN15 interacts with BTRC to promote oesophageal squamous cell carcinoma metastasis via activating NF-κB signaling
title_sort	tspan15 interacts with btrc to promote oesophageal squamous cell carcinoma metastasis via activating nf-κb signaling
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2d3e5f6cc5824d78aea4b2ad946071fd
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TSPAN15 interacts with BTRC to promote oesophageal squamous cell carcinoma metastasis via activating NF-κB signaling

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