Tracking stem cells with superparamagnetic iron oxide nanoparticles: perspectives and considerations

Jasmin,1,* Gustavo Torres de Souza,2,3,* Ruy Andrade Louzada,4 Paulo Henrique Rosado-de-Castro,5 Rosalia Mendez-Otero,6 Antonio Carlos Campos de Carvalho61NUMPEX-Bio, Federal University of Rio de Janeiro, Duque de Caxias, RJ, 2Laboratory of Animal Reproduction, Embrapa Dairy Cattle, Juiz de...

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Autores principales:	Jasmin, Souza GT, Louzada RA, Rosado-de-Castro PH, Mendez-Otero R, Campos de Carvalho AC
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Nanoparticles superparamagnetic iron oxide nanoparticles stem cells cell tracking in vivo imaging myocardial infarction Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2d471067406c4b859547a0841ff0aa8e
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spelling	oai:doaj.org-article:2d471067406c4b859547a0841ff0aa8e2021-12-02T02:42:19ZTracking stem cells with superparamagnetic iron oxide nanoparticles: perspectives and considerations1178-2013https://doaj.org/article/2d471067406c4b859547a0841ff0aa8e2017-01-01T00:00:00Zhttps://www.dovepress.com/tracking-stem-cells-with-superparamagnetic-iron-oxide-nanoparticles-pe-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Jasmin,1,* Gustavo Torres de Souza,2,3,* Ruy Andrade Louzada,4 Paulo Henrique Rosado-de-Castro,5 Rosalia Mendez-Otero,6 Antonio Carlos Campos de Carvalho61NUMPEX-Bio, Federal University of Rio de Janeiro, Duque de Caxias, RJ, 2Laboratory of Animal Reproduction, Embrapa Dairy Cattle, Juiz de Fora, MG, 3Laboratory of Genetics, Federal University of Juiz de Fora, Juiz de Fora, MG, Brazil; 4Institute Gustave-Roussy of Oncology, Paris-Sud University, Villejuif, France; 5Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, 6Institute Carlos Chagas Filho of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil *These authors contributed equally to this work Abstract: Superparamagnetic iron oxide nanoparticles (SPIONs) have been used for diagnoses in biomedical applications, due to their unique properties and their apparent safety for humans. In general, SPIONs do not seem to produce cell damage, although their long-term in vivo effects continue to be investigated. The possibility of efficiently labeling cells with these magnetic nanoparticles has stimulated their use to noninvasively track cells by magnetic resonance imaging after transplantation. SPIONs are attracting increasing attention and are one of the preferred methods for cell labeling and tracking in preclinical and clinical studies. For clinical protocol approval of magnetic-labeled cell tracking, it is essential to expand our knowledge of the time course of SPIONs after cell incorporation and transplantation. This review focuses on the recent advances in tracking SPION-labeled stem cells, analyzing the possibilities and limitations of their use, not only focusing on myocardial infarction but also discussing other models. Keywords: nanoparticles, superparamagnetic iron oxide nanoparticles, stem cells, cell tracking, in vivo imaging, myocardial infarctionJasminSouza GTLouzada RARosado-de-Castro PHMendez-Otero RCampos de Carvalho ACDove Medical PressarticleNanoparticlessuperparamagnetic iron oxide nanoparticlesstem cellscell trackingin vivo imagingmyocardial infarctionMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 779-793 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Nanoparticles superparamagnetic iron oxide nanoparticles stem cells cell tracking in vivo imaging myocardial infarction Medicine (General) R5-920
spellingShingle	Nanoparticles superparamagnetic iron oxide nanoparticles stem cells cell tracking in vivo imaging myocardial infarction Medicine (General) R5-920 Jasmin Souza GT Louzada RA Rosado-de-Castro PH Mendez-Otero R Campos de Carvalho AC Tracking stem cells with superparamagnetic iron oxide nanoparticles: perspectives and considerations
description	Jasmin,1,* Gustavo Torres de Souza,2,3,* Ruy Andrade Louzada,4 Paulo Henrique Rosado-de-Castro,5 Rosalia Mendez-Otero,6 Antonio Carlos Campos de Carvalho61NUMPEX-Bio, Federal University of Rio de Janeiro, Duque de Caxias, RJ, 2Laboratory of Animal Reproduction, Embrapa Dairy Cattle, Juiz de Fora, MG, 3Laboratory of Genetics, Federal University of Juiz de Fora, Juiz de Fora, MG, Brazil; 4Institute Gustave-Roussy of Oncology, Paris-Sud University, Villejuif, France; 5Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, 6Institute Carlos Chagas Filho of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil *These authors contributed equally to this work Abstract: Superparamagnetic iron oxide nanoparticles (SPIONs) have been used for diagnoses in biomedical applications, due to their unique properties and their apparent safety for humans. In general, SPIONs do not seem to produce cell damage, although their long-term in vivo effects continue to be investigated. The possibility of efficiently labeling cells with these magnetic nanoparticles has stimulated their use to noninvasively track cells by magnetic resonance imaging after transplantation. SPIONs are attracting increasing attention and are one of the preferred methods for cell labeling and tracking in preclinical and clinical studies. For clinical protocol approval of magnetic-labeled cell tracking, it is essential to expand our knowledge of the time course of SPIONs after cell incorporation and transplantation. This review focuses on the recent advances in tracking SPION-labeled stem cells, analyzing the possibilities and limitations of their use, not only focusing on myocardial infarction but also discussing other models. Keywords: nanoparticles, superparamagnetic iron oxide nanoparticles, stem cells, cell tracking, in vivo imaging, myocardial infarction
format	article
author	Jasmin Souza GT Louzada RA Rosado-de-Castro PH Mendez-Otero R Campos de Carvalho AC
author_facet	Jasmin Souza GT Louzada RA Rosado-de-Castro PH Mendez-Otero R Campos de Carvalho AC
author_sort	Jasmin
title	Tracking stem cells with superparamagnetic iron oxide nanoparticles: perspectives and considerations
title_short	Tracking stem cells with superparamagnetic iron oxide nanoparticles: perspectives and considerations
title_full	Tracking stem cells with superparamagnetic iron oxide nanoparticles: perspectives and considerations
title_fullStr	Tracking stem cells with superparamagnetic iron oxide nanoparticles: perspectives and considerations
title_full_unstemmed	Tracking stem cells with superparamagnetic iron oxide nanoparticles: perspectives and considerations
title_sort	tracking stem cells with superparamagnetic iron oxide nanoparticles: perspectives and considerations
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/2d471067406c4b859547a0841ff0aa8e
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_version_	1718402208134856704

Tracking stem cells with superparamagnetic iron oxide nanoparticles: perspectives and considerations

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