Association of S100B polymorphisms and serum S100B with risk of ischemic stroke in a Chinese population

Abstract The levels of serum S100B were elevated in patients with ischemic stroke (IS), which may be a novel biomarker for diagnosing IS. The aim of this study was to investigate the association of S100B polymorphisms and serum S100B with IS risk. We genotyped the S100B polymorphisms rs9722, rs99847...

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Autores principales:	Yu-Lan Lu, Rong Wang, Hua-Tuo Huang, Hai-Mei Qin, Chun-Hong Liu, Yang Xiang, Chun-Fang Wang, Hong-Cheng Luo, Jun-Li Wang, Yan Lan, Ye-Sheng Wei
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2d4880b27c5346359a16036ad6339d81
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spelling	oai:doaj.org-article:2d4880b27c5346359a16036ad6339d812021-12-02T15:08:19ZAssociation of S100B polymorphisms and serum S100B with risk of ischemic stroke in a Chinese population10.1038/s41598-018-19156-w2045-2322https://doaj.org/article/2d4880b27c5346359a16036ad6339d812018-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-19156-whttps://doaj.org/toc/2045-2322Abstract The levels of serum S100B were elevated in patients with ischemic stroke (IS), which may be a novel biomarker for diagnosing IS. The aim of this study was to investigate the association of S100B polymorphisms and serum S100B with IS risk. We genotyped the S100B polymorphisms rs9722, rs9984765, rs2839356, rs1051169 and rs2186358 in 396 IS patients and 398 controls using polymerase chain reaction-single base extension (SBE-PCR). Serum S100B levels were measured by enzyme-linked immunosorbent assay (ELISA). Rs9722 was associated with an increased risk of IS (AA vs. GG: adjusted OR = 2.172, 95% CI, 1.175–4.014, P = 0.013; dominant: adjusted OR = 1.507, 95% CI, 1.071–2.123, P = 0.019; recessive: adjusted OR = 1.846, 95% CI, 1.025–3.323, P = 0.041; additive: adjusted OR=1.371, 95% CI, 1.109-1.694, P = 0.003). The A-C-C-C-A haplotype was associated with an increased risk of IS (OR = 1.325, 95% CI, 1.035–1.696, P = 0.025). In addition, individuals carrying the rs9722 GA/AA genotypes had a higher serum S100B compared with the rs9722 GG genotype in IS patients (P = 0.018). Our results suggest that the S100B gene rs9722 polymorphism may contribute to the susceptibility of IS, probably by promoting the expression of serum S100B.Yu-Lan LuRong WangHua-Tuo HuangHai-Mei QinChun-Hong LiuYang XiangChun-Fang WangHong-Cheng LuoJun-Li WangYan LanYe-Sheng WeiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yu-Lan Lu Rong Wang Hua-Tuo Huang Hai-Mei Qin Chun-Hong Liu Yang Xiang Chun-Fang Wang Hong-Cheng Luo Jun-Li Wang Yan Lan Ye-Sheng Wei Association of S100B polymorphisms and serum S100B with risk of ischemic stroke in a Chinese population
description	Abstract The levels of serum S100B were elevated in patients with ischemic stroke (IS), which may be a novel biomarker for diagnosing IS. The aim of this study was to investigate the association of S100B polymorphisms and serum S100B with IS risk. We genotyped the S100B polymorphisms rs9722, rs9984765, rs2839356, rs1051169 and rs2186358 in 396 IS patients and 398 controls using polymerase chain reaction-single base extension (SBE-PCR). Serum S100B levels were measured by enzyme-linked immunosorbent assay (ELISA). Rs9722 was associated with an increased risk of IS (AA vs. GG: adjusted OR = 2.172, 95% CI, 1.175–4.014, P = 0.013; dominant: adjusted OR = 1.507, 95% CI, 1.071–2.123, P = 0.019; recessive: adjusted OR = 1.846, 95% CI, 1.025–3.323, P = 0.041; additive: adjusted OR=1.371, 95% CI, 1.109-1.694, P = 0.003). The A-C-C-C-A haplotype was associated with an increased risk of IS (OR = 1.325, 95% CI, 1.035–1.696, P = 0.025). In addition, individuals carrying the rs9722 GA/AA genotypes had a higher serum S100B compared with the rs9722 GG genotype in IS patients (P = 0.018). Our results suggest that the S100B gene rs9722 polymorphism may contribute to the susceptibility of IS, probably by promoting the expression of serum S100B.
format	article
author	Yu-Lan Lu Rong Wang Hua-Tuo Huang Hai-Mei Qin Chun-Hong Liu Yang Xiang Chun-Fang Wang Hong-Cheng Luo Jun-Li Wang Yan Lan Ye-Sheng Wei
author_facet	Yu-Lan Lu Rong Wang Hua-Tuo Huang Hai-Mei Qin Chun-Hong Liu Yang Xiang Chun-Fang Wang Hong-Cheng Luo Jun-Li Wang Yan Lan Ye-Sheng Wei
author_sort	Yu-Lan Lu
title	Association of S100B polymorphisms and serum S100B with risk of ischemic stroke in a Chinese population
title_short	Association of S100B polymorphisms and serum S100B with risk of ischemic stroke in a Chinese population
title_full	Association of S100B polymorphisms and serum S100B with risk of ischemic stroke in a Chinese population
title_fullStr	Association of S100B polymorphisms and serum S100B with risk of ischemic stroke in a Chinese population
title_full_unstemmed	Association of S100B polymorphisms and serum S100B with risk of ischemic stroke in a Chinese population
title_sort	association of s100b polymorphisms and serum s100b with risk of ischemic stroke in a chinese population
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2d4880b27c5346359a16036ad6339d81
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Association of S100B polymorphisms and serum S100B with risk of ischemic stroke in a Chinese population

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