Determinants of peripapillary retinal nerve fiber layer’s grayscale value in normal eyes by spectral domain optical coherence tomography

Abstract To determine and evaluate the distribution, variation, and determinants of peripapillary retinal nerve fiber layer (pRNFL) grayscale value with spectral-domain optical coherence tomography (SD-OCT) in normal eyes. In this cross-sectional study, three hundred ninety-seven normal eyes from 39...

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Autores principales:	Xiaolin Xie, Binyao Chen, Jianling Yang, Chukai Huang, Kunliang Qiu, Ce Zheng, Mingzhi Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2d496c17836d469991469ced67846973
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spelling	oai:doaj.org-article:2d496c17836d469991469ced678469732021-12-02T15:37:58ZDeterminants of peripapillary retinal nerve fiber layer’s grayscale value in normal eyes by spectral domain optical coherence tomography10.1038/s41598-021-88604-x2045-2322https://doaj.org/article/2d496c17836d469991469ced678469732021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88604-xhttps://doaj.org/toc/2045-2322Abstract To determine and evaluate the distribution, variation, and determinants of peripapillary retinal nerve fiber layer (pRNFL) grayscale value with spectral-domain optical coherence tomography (SD-OCT) in normal eyes. In this cross-sectional study, three hundred ninety-seven normal eyes from 397 healthy Chinese adults aged 18–80 were consecutively recruited from a tertiary eye care center. An SD-OCT instrument took pRNFL imaging. We used a customized software to measure pRNFL parameters, including thickness and grayscale value. Univariable and multiple linear regression analyses were performed to examine the relationship between pRNFL grayscale value with ocular (e.g., axial length [A.L.], spherical equivalent [S.E.], intraocular pressure [IOP]), and systemic (e.g., age, sex) factors. A total of 397 eyes from 397 healthy subjects were included in the final analysis with mean (± SD) age 44.63 ± 16.43 years (range 18–80 years) and 196 (49.4%) males. The mean average of pRNFL grayscale value and thickness 164.82 ± 5.69 and 106.68 ± 8.89 μm, respectively. pRNFL grayscale value in nasal sectors (163.26 ± 9.31) was significantly lower comparing those in all other five sectors (all with p < 0.001)]. In multivariable analysis, average pRNFL grayscale value was independently correlated to older age (β = − 0.053, p = 0.002), longer axial length (β = − 0.664, p = 0.003), lower RPE grayscale value (β = 0.372, p < 0.001) and lower ImageQ (β = 0.658, p < 0.001). In this study, we provided normative SD-OCT data on the pRNFL grayscale value profile in nonglaucomatous eyes. Lower average pRNFL grayscale value was independently correlated to older age, longer axial length, lower RPE grayscale value, and lower ImageQ. These determinants should be considered when interpreting pRNFL grayscale value in glaucoma assessment.Xiaolin XieBinyao ChenJianling YangChukai HuangKunliang QiuCe ZhengMingzhi ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiaolin Xie Binyao Chen Jianling Yang Chukai Huang Kunliang Qiu Ce Zheng Mingzhi Zhang Determinants of peripapillary retinal nerve fiber layer’s grayscale value in normal eyes by spectral domain optical coherence tomography
description	Abstract To determine and evaluate the distribution, variation, and determinants of peripapillary retinal nerve fiber layer (pRNFL) grayscale value with spectral-domain optical coherence tomography (SD-OCT) in normal eyes. In this cross-sectional study, three hundred ninety-seven normal eyes from 397 healthy Chinese adults aged 18–80 were consecutively recruited from a tertiary eye care center. An SD-OCT instrument took pRNFL imaging. We used a customized software to measure pRNFL parameters, including thickness and grayscale value. Univariable and multiple linear regression analyses were performed to examine the relationship between pRNFL grayscale value with ocular (e.g., axial length [A.L.], spherical equivalent [S.E.], intraocular pressure [IOP]), and systemic (e.g., age, sex) factors. A total of 397 eyes from 397 healthy subjects were included in the final analysis with mean (± SD) age 44.63 ± 16.43 years (range 18–80 years) and 196 (49.4%) males. The mean average of pRNFL grayscale value and thickness 164.82 ± 5.69 and 106.68 ± 8.89 μm, respectively. pRNFL grayscale value in nasal sectors (163.26 ± 9.31) was significantly lower comparing those in all other five sectors (all with p < 0.001)]. In multivariable analysis, average pRNFL grayscale value was independently correlated to older age (β = − 0.053, p = 0.002), longer axial length (β = − 0.664, p = 0.003), lower RPE grayscale value (β = 0.372, p < 0.001) and lower ImageQ (β = 0.658, p < 0.001). In this study, we provided normative SD-OCT data on the pRNFL grayscale value profile in nonglaucomatous eyes. Lower average pRNFL grayscale value was independently correlated to older age, longer axial length, lower RPE grayscale value, and lower ImageQ. These determinants should be considered when interpreting pRNFL grayscale value in glaucoma assessment.
format	article
author	Xiaolin Xie Binyao Chen Jianling Yang Chukai Huang Kunliang Qiu Ce Zheng Mingzhi Zhang
author_facet	Xiaolin Xie Binyao Chen Jianling Yang Chukai Huang Kunliang Qiu Ce Zheng Mingzhi Zhang
author_sort	Xiaolin Xie
title	Determinants of peripapillary retinal nerve fiber layer’s grayscale value in normal eyes by spectral domain optical coherence tomography
title_short	Determinants of peripapillary retinal nerve fiber layer’s grayscale value in normal eyes by spectral domain optical coherence tomography
title_full	Determinants of peripapillary retinal nerve fiber layer’s grayscale value in normal eyes by spectral domain optical coherence tomography
title_fullStr	Determinants of peripapillary retinal nerve fiber layer’s grayscale value in normal eyes by spectral domain optical coherence tomography
title_full_unstemmed	Determinants of peripapillary retinal nerve fiber layer’s grayscale value in normal eyes by spectral domain optical coherence tomography
title_sort	determinants of peripapillary retinal nerve fiber layer’s grayscale value in normal eyes by spectral domain optical coherence tomography
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2d496c17836d469991469ced67846973
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Determinants of peripapillary retinal nerve fiber layer’s grayscale value in normal eyes by spectral domain optical coherence tomography

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