Alterations of white matter fractional anisotropy in unmedicated obsessive–compulsive disorder
Jiong Tao,1,2 Xianglan Wang,2 Zhiyong Zhong,1,2 Hongying Han,2 Sha Liu,3 Shenglin Wen,4 Nianhong Guan,2 Lingjiang Li1 1Mental Health Institute of the Second Xiangya Hospital, Central South University, Changsha, 2Department of Psychiatry, The Third Affiliated Hospital of Sun Yat-sen University, 3Dep...
Guardado en:
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2016
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/2d49bc6bcf28435d976de7c7e7fa98e4 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:2d49bc6bcf28435d976de7c7e7fa98e4 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:2d49bc6bcf28435d976de7c7e7fa98e42021-12-02T00:46:18ZAlterations of white matter fractional anisotropy in unmedicated obsessive–compulsive disorder1178-2021https://doaj.org/article/2d49bc6bcf28435d976de7c7e7fa98e42016-12-01T00:00:00Zhttps://www.dovepress.com/alterations-of-white-matter-fractional-anisotropy--in-unmedicated-obse-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Jiong Tao,1,2 Xianglan Wang,2 Zhiyong Zhong,1,2 Hongying Han,2 Sha Liu,3 Shenglin Wen,4 Nianhong Guan,2 Lingjiang Li1 1Mental Health Institute of the Second Xiangya Hospital, Central South University, Changsha, 2Department of Psychiatry, The Third Affiliated Hospital of Sun Yat-sen University, 3Department of Radiology, Guangzhou Huiai Hospital, Guangzhou, 4Department of Psychiatry, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, People’s Republic of China Background: Abnormalities in white matter (WM) have previously been reported in patients with obsessive–compulsive disorder (OCD). However, there was some inconsistency in the results obtained for altered regions of WM. The aim of this study was to investigate fractional anisotropy (FA) in the WM of the whole brain in patients with OCD by using diffusion tensor imaging (DTI).Methods: In total, 28 unmedicated patients with OCD and 28 healthy volunteers underwent DTI scan. A voxel-based analysis was used to compare FA values in WM of the two groups at a voxel threshold of P<0.005 with an extent threshold of k>72 voxels (P<0.05; Alphasim correction). Subsequently, correlation analysis was conducted in order to find the correlation between the mean FA values in significantly altered brain regions and Yale–Brown Obsessive Compulsive Scale (Y-BOCS) scores of the OCD patients.Results: Compared with healthy volunteers, the OCD patients had lower FA value in the left lingual gyrus, right midbrain, and right precuneus. There were no regions with significantly higher FA values in OCD patients compared with healthy volunteers. The mean FA values in the above regions (left lingual, r=0.019, P=0.923; right midbrain, r=-0.208, P=0.289; and right precuneus, r=-0.273, P=0.161) had no significant correlation with the Y-BOCS scores of the OCD patients.Conclusion: The findings of this study suggest that alterations in WM of the left lingual gyrus, right midbrain, and right precuneus are associated with the pathophysiology mechanism of OCD, and these microstructural alterations do not correlate with symptom severity of OCD. Keywords: white matter, diffusion tensor imaging, fractional anisotropy, obsessive–compulsive disorderTao JWang XLZhong ZYHan HYLiu SWen SLGuan NHLi LJDove Medical PressarticleWhite MatterDiffusion Tensor ImagingFractional AnisotropyObsessive-Compulsive DisorderNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 69-76 (2016) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
White Matter Diffusion Tensor Imaging Fractional Anisotropy Obsessive-Compulsive Disorder Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
| spellingShingle |
White Matter Diffusion Tensor Imaging Fractional Anisotropy Obsessive-Compulsive Disorder Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Tao J Wang XL Zhong ZY Han HY Liu S Wen SL Guan NH Li LJ Alterations of white matter fractional anisotropy in unmedicated obsessive–compulsive disorder |
| description |
Jiong Tao,1,2 Xianglan Wang,2 Zhiyong Zhong,1,2 Hongying Han,2 Sha Liu,3 Shenglin Wen,4 Nianhong Guan,2 Lingjiang Li1 1Mental Health Institute of the Second Xiangya Hospital, Central South University, Changsha, 2Department of Psychiatry, The Third Affiliated Hospital of Sun Yat-sen University, 3Department of Radiology, Guangzhou Huiai Hospital, Guangzhou, 4Department of Psychiatry, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, People’s Republic of China Background: Abnormalities in white matter (WM) have previously been reported in patients with obsessive–compulsive disorder (OCD). However, there was some inconsistency in the results obtained for altered regions of WM. The aim of this study was to investigate fractional anisotropy (FA) in the WM of the whole brain in patients with OCD by using diffusion tensor imaging (DTI).Methods: In total, 28 unmedicated patients with OCD and 28 healthy volunteers underwent DTI scan. A voxel-based analysis was used to compare FA values in WM of the two groups at a voxel threshold of P<0.005 with an extent threshold of k>72 voxels (P<0.05; Alphasim correction). Subsequently, correlation analysis was conducted in order to find the correlation between the mean FA values in significantly altered brain regions and Yale–Brown Obsessive Compulsive Scale (Y-BOCS) scores of the OCD patients.Results: Compared with healthy volunteers, the OCD patients had lower FA value in the left lingual gyrus, right midbrain, and right precuneus. There were no regions with significantly higher FA values in OCD patients compared with healthy volunteers. The mean FA values in the above regions (left lingual, r=0.019, P=0.923; right midbrain, r=-0.208, P=0.289; and right precuneus, r=-0.273, P=0.161) had no significant correlation with the Y-BOCS scores of the OCD patients.Conclusion: The findings of this study suggest that alterations in WM of the left lingual gyrus, right midbrain, and right precuneus are associated with the pathophysiology mechanism of OCD, and these microstructural alterations do not correlate with symptom severity of OCD. Keywords: white matter, diffusion tensor imaging, fractional anisotropy, obsessive–compulsive disorder |
| format |
article |
| author |
Tao J Wang XL Zhong ZY Han HY Liu S Wen SL Guan NH Li LJ |
| author_facet |
Tao J Wang XL Zhong ZY Han HY Liu S Wen SL Guan NH Li LJ |
| author_sort |
Tao J |
| title |
Alterations of white matter fractional anisotropy in unmedicated obsessive–compulsive disorder |
| title_short |
Alterations of white matter fractional anisotropy in unmedicated obsessive–compulsive disorder |
| title_full |
Alterations of white matter fractional anisotropy in unmedicated obsessive–compulsive disorder |
| title_fullStr |
Alterations of white matter fractional anisotropy in unmedicated obsessive–compulsive disorder |
| title_full_unstemmed |
Alterations of white matter fractional anisotropy in unmedicated obsessive–compulsive disorder |
| title_sort |
alterations of white matter fractional anisotropy in unmedicated obsessive–compulsive disorder |
| publisher |
Dove Medical Press |
| publishDate |
2016 |
| url |
https://doaj.org/article/2d49bc6bcf28435d976de7c7e7fa98e4 |
| work_keys_str_mv |
AT taoj alterationsofwhitematterfractionalanisotropyinunmedicatedobsessivendashcompulsivedisorder AT wangxl alterationsofwhitematterfractionalanisotropyinunmedicatedobsessivendashcompulsivedisorder AT zhongzy alterationsofwhitematterfractionalanisotropyinunmedicatedobsessivendashcompulsivedisorder AT hanhy alterationsofwhitematterfractionalanisotropyinunmedicatedobsessivendashcompulsivedisorder AT lius alterationsofwhitematterfractionalanisotropyinunmedicatedobsessivendashcompulsivedisorder AT wensl alterationsofwhitematterfractionalanisotropyinunmedicatedobsessivendashcompulsivedisorder AT guannh alterationsofwhitematterfractionalanisotropyinunmedicatedobsessivendashcompulsivedisorder AT lilj alterationsofwhitematterfractionalanisotropyinunmedicatedobsessivendashcompulsivedisorder |
| _version_ |
1718403482495483904 |